Longitudinal study of cervical squamous intraepithelial lesions in human immunodefidency virus (HIV)-seropositive and at-risk HIV-seronegative women

Paula Schuman, Suzanne E. Ohmit, Robert S. Klein, Ann Duerr, Susan Cu-Uvin, Denise J. Jamieson, Jean Anderson, Keerti V. Shah

Research output: Contribution to journalArticle


We examined incidence and correlates of progression and regression of abnormal cervical cytologic test results, defined as at least low-grade squamous intraepithelial lesions (SILs), in 774 human immunodeficiency virus (HIV) - seropositive and 391 HIV-seronegative women monitored semiannually for up to 5.5 years. During follow-up, 224 (35%) HIV-seropositive women and 34 (9%) HIV-seronegative women had incident SILs detected by Pap test; 47 (7%) HIV-seropositive women developed high-grade lesions. The incidence of SILs was 11.5 cases among HIV-seropositive and 2.6 cases among HIV-seronegative women per 100 person-years of observation (rate ratio, 4.5; 95% confidence interval, 3.1-6.4; P <.001). Risk of incident SILs and likelihood of Pap test progression were increased among HIV-seropositive women with CD4+ lymphocyte counts 3 and among women with human papillomavirus (HPV) infection, with risk-ordering from low- to high-risk HPV type. SIL regression was less likely among HIV-seropositive women with higher HIV loads. No beneficial effect of highly active antiretroviral therapy was demonstrated.

Original languageEnglish (US)
Pages (from-to)128-136
Number of pages9
JournalJournal of Infectious Diseases
Issue number1
Publication statusPublished - Jul 1 2003


ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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