Longitudinal serological measures of common infection in the Avon Longitudinal study of parents and children cohort [version 2; referees: 2 approved]

Ruth E. Mitchell, Hannah J. Jones, Robert H. Yolken, Glen Ford, Lorraine Jones-Brando, Susan M. Ring, Alix Groom, Sophie Fitzgibbon, George Davey Smith, Nicholas J. Timpson

Research output: Contribution to journalComment/debatepeer-review

Abstract

Antibodies against pathogens provide information on exposure to infectious agents and are meaningful measures of past and present infection. Antibodies were measured in the plasma of children that are the offspring in a population-based birth cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC). Plasma was collected during clinics at age 5, 7, 11 and 15 years. The antigens examined include: fungal (Saccharomyces cerevisiae); protozoan (Toxoplasma gondii and surface antigen 1 of T. gondii); herpes viruses (cytomegalovirus, Epstein-Barr virus, herpes simplex virus type 1); common colds (influenza virus subtypes H1N1 and H3N2); other antigens (measles); animal (feline herpes virus, Theiler’s virus); bacteria (Helicobacter pylori); dietary antigens (bovine casein alpha protein, bovine casein beta protein). Alongside the depth of data available within the ALSPAC cohort, this longitudinal resource will enable the investigation of the association between infections and a wide variety of outcomes.

Original languageEnglish (US)
Article number49
JournalWellcome Open Research
Volume3
DOIs
StatePublished - 2018

Keywords

  • ALSPAC
  • Antibody
  • Infection

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)

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