Abstract
The age-associated increase in arterial stiffness has long been considered to parallel or to cause the age-associated increase in blood pressure (BP). Yet, the rates at which pulse wave velocity (PWV), a measure of arterial stiffness, and BP trajectories change over time within individuals who differ by age and sex have not been assessed and compared. This study determined the evolution of BP and aortic PWV trajectories during a 9.4-year follow-up in >4000 communitydwelling men and women of 20 to 100 years of age at entry into the SardiNIA Study. Linear mixed effects model analyses revealed that PWV accelerates with time during the observation period, at about the same rate over the entire age range in both men and women. In men, the longitudinal rate at which BP changed over time, however, did not generally parallel that of PWV acceleration: at ages
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1219-1227 |
| Number of pages | 9 |
| Journal | Hypertension |
| Volume | 64 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2014 |
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Keywords
- Aging
- Arteries
- Blood pressure
- Longitudinal studies
- Pulse wave analysis
- Sex
ASJC Scopus subject areas
- Internal Medicine
- Medicine(all)
Cite this
Longitudinal perspective on the conundrum of central arterial stiffness, blood pressure, and aging. / Scuteri, Angelo; Morrell, Christopher H.; Orrù, Marco; Strait, James B.; Tarasov, Kirill V.; Ferreli, Liana Anna Pina; Loi, Francesco; Pilia, Maria Grazia; Delitala, Alessandro; Spurgeon, Harold; Najjar, Samer S.; AlGhatrif, Majd; Lakatta, Edward.
In: Hypertension, Vol. 64, No. 6, 2014, p. 1219-1227.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Longitudinal perspective on the conundrum of central arterial stiffness, blood pressure, and aging
AU - Scuteri, Angelo
AU - Morrell, Christopher H.
AU - Orrù, Marco
AU - Strait, James B.
AU - Tarasov, Kirill V.
AU - Ferreli, Liana Anna Pina
AU - Loi, Francesco
AU - Pilia, Maria Grazia
AU - Delitala, Alessandro
AU - Spurgeon, Harold
AU - Najjar, Samer S.
AU - AlGhatrif, Majd
AU - Lakatta, Edward
PY - 2014
Y1 - 2014
N2 - The age-associated increase in arterial stiffness has long been considered to parallel or to cause the age-associated increase in blood pressure (BP). Yet, the rates at which pulse wave velocity (PWV), a measure of arterial stiffness, and BP trajectories change over time within individuals who differ by age and sex have not been assessed and compared. This study determined the evolution of BP and aortic PWV trajectories during a 9.4-year follow-up in >4000 communitydwelling men and women of 20 to 100 years of age at entry into the SardiNIA Study. Linear mixed effects model analyses revealed that PWV accelerates with time during the observation period, at about the same rate over the entire age range in both men and women. In men, the longitudinal rate at which BP changed over time, however, did not generally parallel that of PWV acceleration: at ages
AB - The age-associated increase in arterial stiffness has long been considered to parallel or to cause the age-associated increase in blood pressure (BP). Yet, the rates at which pulse wave velocity (PWV), a measure of arterial stiffness, and BP trajectories change over time within individuals who differ by age and sex have not been assessed and compared. This study determined the evolution of BP and aortic PWV trajectories during a 9.4-year follow-up in >4000 communitydwelling men and women of 20 to 100 years of age at entry into the SardiNIA Study. Linear mixed effects model analyses revealed that PWV accelerates with time during the observation period, at about the same rate over the entire age range in both men and women. In men, the longitudinal rate at which BP changed over time, however, did not generally parallel that of PWV acceleration: at ages
KW - Aging
KW - Arteries
KW - Blood pressure
KW - Longitudinal studies
KW - Pulse wave analysis
KW - Sex
UR - http://www.scopus.com/inward/record.url?scp=84922480896&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922480896&partnerID=8YFLogxK
U2 - 10.1161/HYPERTENSIONAHA.114.04127
DO - 10.1161/HYPERTENSIONAHA.114.04127
M3 - Article
C2 - 25225210
AN - SCOPUS:84922480896
VL - 64
SP - 1219
EP - 1227
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 6
ER -