Longitudinal perspective on the conundrum of central arterial stiffness, blood pressure, and aging

Angelo Scuteri, Christopher H. Morrell, Marco Orrù, James B. Strait, Kirill V. Tarasov, Liana Anna Pina Ferreli, Francesco Loi, Maria Grazia Pilia, Alessandro Delitala, Harold Spurgeon, Samer S. Najjar, Majd Alghatrif, Edward G. Lakatta

Research output: Contribution to journalArticlepeer-review


The age-associated increase in arterial stiffness has long been considered to parallel or to cause the age-associated increase in blood pressure (BP). Yet, the rates at which pulse wave velocity (PWV), a measure of arterial stiffness, and BP trajectories change over time within individuals who differ by age and sex have not been assessed and compared. This study determined the evolution of BP and aortic PWV trajectories during a 9.4-year follow-up in >4000 communitydwelling men and women of 20 to 100 years of age at entry into the SardiNIA Study. Linear mixed effects model analyses revealed that PWV accelerates with time during the observation period, at about the same rate over the entire age range in both men and women. In men, the longitudinal rate at which BP changed over time, however, did not generally parallel that of PWV acceleration: at ages <40 years the rates of change in systolic BP (SBP) and pulse pressure (PP) increase plateaued and then declined so that SBP, itself, also declined at older ages, whereas PP plateaued. In women, SBP, diastolic BP, and mean BP increased at constant rates across all ages, producing an increasing rate of increase in PP. Therefore, increased aortic stiffness is implicated in the age-associated increase in SBP and PP. These findings indicate that PWV is not a surrogate for BP and that arterial properties other than arterial wall stiffness that vary by age and sex also modulate the BP trajectories during aging and lead to the dissociation of PWV, PP, and SBP trajectories in men.

Original languageEnglish (US)
Pages (from-to)1219-1227
Number of pages9
Issue number6
StatePublished - 2014


  • Aging
  • Arteries
  • Blood pressure
  • Longitudinal studies
  • Pulse wave analysis
  • Sex

ASJC Scopus subject areas

  • Internal Medicine


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