Abstract
Abstract: Idiopathic normal pressure hydrocephalus is a neurological disease caused by abnormal cerebrospinal fluid flow and presents with symptoms such as dementia. Current therapy involves the removal of excess cerebrospinal fluid by shunting. Not all patients respond to this therapy and biomarkers are needed that could facilitate the characterization of patients likely to benefit from this treatment. Here, we measure brain metabolism in normal pressure hydrocephalus patients by performing a novel longitudinal metabolomic profiling study of cerebrospinal fluid. We find that the levels of brain metabolites correlate with clinical parameters, the amount of vascular endothelial growth factor in the cerebrospinal fluid, and environmental stimuli such as exercise. Metabolomic analysis of normal pressure hydrocephalus patients provides insight into changes in brain metabolism that accompany cerebrospinal fluid disorders and may facilitate the development of new biomarkers for this condition. Graphical Abstract: [Figure not available: see fulltext.]
Original language | English (US) |
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Pages (from-to) | 1713-1722 |
Number of pages | 10 |
Journal | Neurochemical Research |
Volume | 41 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1 2016 |
Keywords
- Cerebrospinal fluid
- Exercise
- Global metabolomics
- Normal pressure hydrocephalus
- Vascular endothelial growth factor
ASJC Scopus subject areas
- Biochemistry
- Cellular and Molecular Neuroscience