Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer's disease

Meiyan Huang, Wei Yang, Qianjin Feng, Wufan Chen, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Jeffrey Kaye, Joseph Quinn, Lisa Silbert, Betty LindRaina Carter, Sara Dolen, Lon S. Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro, Bryan M. Spann, James Brewer, Helen Vanderswag, Adam Fleisher, Judith L. Heidebrink, Joanne L. Lord, Sara S. Mason, Colleen S. Albers, David Knopman, Kris Johnson, Rachelle S. Doody, Javier Villanueva-Meyer, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S. Honig, Karen L. Bell, Beau Ances, John C. Morris, Maria Carroll, Mary L. Creech, Erin Franklin, Mark A. Mintun, Stacy Schneider, Angela Oliver, Daniel Marson, Randall Griffith, David Clark, David Geldmacher, John Brockington, Erik Roberson, Marissa Natelson Love, Hillel Grossman, Effie Mitsis, Raj C. Shah, Leyla DeToledo-Morrell, Ranjan Duara, Daniel Varon, Maria T. Greig, Marilyn Albert, Chiadikaobi U Onyike, Chiadi Onyike, Daniel D'Agostino, Stephanie Kielb, James E. Galvin, Brittany Cerbone, Christina A. Michel, Dana M. Pogorelec, Henry Rusinek, Mony J. De Leon, Lidia Glodzik, Susan De Santi, P. Murali Doraiswamy, Jeffrey R. Petrella, Salvador Borges-Neto, Terence Z. Wong, Edward Coleman, Charles D. Smith, Greg Jicha, Peter Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Anton P. Porsteinsson, Bonnie S. Goldstein, Kim Martin, Kelly M. Makino, M. Saleem Ismail, Connie Brand, Ruth A. Mulnard, Gaby Thai, Catherine Mc-Adams-Ortiz, Kyle Womack, Dana Mathews, Mary Quiceno, Allan I. Levey, James J. Lah, Janet S. Cellar, Jeffrey M. Burns, Russell H. Swerdlow, William M. Brooks, Liana Apostolova, Kathleen Tingus, Ellen Woo, Daniel H S Silverman, Po H. Lu, George Bartzokis, Neill R. Graff-Radford, Francine Parfitt, Tracy Kendall, Heather Johnson, Martin R. Farlow, Ann Marie Hake, Jared R. Brosch, Scott Herring, Cynthia Hunt, Christopher H. Van Dyck, Richard E. Carson, Martha G. MacAvoy, Pradeep Varma, Howard Chertkow, Howard Bergman, Chris Hosein, Sandra Black, Bojana Stefanovic, Curtis Caldwell, Ging Yuek Robin Hsiung, Howard Feldman, Benita Mudge, Michele Assaly, Elizabeth Finger, Stephen Pasternack, Irina Rachisky, Dick Trost, Andrew Kertesz, Charles Bernick, Donna Munic, Marek Marsel Mesulam, Kristine Lipowski, Sandra Weintraub, Borna Bonakdarpour, Diana Kerwin, Chuang Kuo Wu, Nancy Johnson, Carl Sadowsky, Teresa Villena, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Reisa A. Sperling, Keith A. Johnson, Gad Marshall, Jerome Yesavage, Joy L. Taylor, Barton Lane, Allyson Rosen, Jared Tinklenberg, Marwan N. Sabbagh, Christine M. Belden, Sandra A. Jacobson, Sherye A. Sirrel, Neil Kowall, Ronald Killiany, Andrew E. Budson, Alexander Norbash, Patricia Lynn Johnson, Thomas O. Obisesan, Saba Wolday, Joanne Allard, Alan Lerner, Paula Ogrocki, Curtis Tatsuoka, Parianne Fatica, Evan Fletcher, Pauline Maillard, John Olichney, Charles DeCarli, Owen Carmichael, Smita Kittur, Michael Borrie, T. Y. Lee, Rob Bartha, Sterling Johnson, Sanjay Asthana, Cynthia M. Carlsson, Steven G. Potkin, Adrian Preda, Dana Nguyen, Pierre Tariot, Anna Burke, Nadira Trncic, Stephanie Reeder, Vernice Bates, Horacio Capote, Michelle Rainka, Douglas W. Scharre, Maria Kataki, Anahita Adeli, Earl A. Zimmerman, Dzintra Celmins, Alice D. Brown, Godfrey D. Pearlson, Karen Blank, Karen Anderson, Laura A. Flashman, Marc Seltzer, Mary L. Hynes, Robert B. Santulli, Kaycee M. Sink, Leslie Gordineer, Jeff D. Williamson, Pradeep Garg, Franklin Watkins, Brian R. Ott, Henry Querfurth, Geoffrey Tremont, Stephen Salloway, Paul Malloy, Stephen Correia, Howard J. Rosen, Bruce L. Miller, David Perry, Jacobo Mintzer, Kenneth Spicer, David Bachman, Nunzio Pomara, Raymundo Hernando, Antero Sarrael, Norman Relkin, Gloria Chaing, Michael Lin, Lisa Ravdin, Amanda Smith, Balebail Ashok Raj, Kristin Fargher

Research output: Contribution to journalArticle

Abstract

Accurate prediction of Alzheimer's disease (AD) is important for the early diagnosis and treatment of this condition. Mild cognitive impairment (MCI) is an early stage of AD. Therefore, patients with MCI who are at high risk of fully developing AD should be identified to accurately predict AD. However, the relationship between brain images and AD is difficult to construct because of the complex characteristics of neuroimaging data. To address this problem, we present a longitudinal measurement of MCI brain images and a hierarchical classification method for AD prediction. Longitudinal images obtained from individuals with MCI were investigated to acquire important information on the longitudinal changes, which can be used to classify MCI subjects as either MCI conversion (MCIc) or MCI non-conversion (MCInc) individuals. Moreover, a hierarchical framework was introduced to the classifier to manage high feature dimensionality issues and incorporate spatial information for improving the prediction accuracy. The proposed method was evaluated using 131 patients with MCI (70 MCIc and 61 MCInc) based on MRI scans taken at different time points. Results showed that the proposed method achieved 79.4% accuracy for the classification of MCIc versus MCInc, thereby demonstrating very promising performance for AD prediction.

Original languageEnglish (US)
Article number39880
JournalScientific Reports
Volume7
DOIs
StatePublished - Jan 12 2017

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Alzheimer Disease
Cognitive Dysfunction
Brain Diseases
Neuroimaging
Early Diagnosis
Magnetic Resonance Imaging
Brain

ASJC Scopus subject areas

  • General

Cite this

Huang, M., Yang, W., Feng, Q., Chen, W., Weiner, M. W., Aisen, P., ... Fargher, K. (2017). Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer's disease. Scientific Reports, 7, [39880]. https://doi.org/10.1038/srep39880

Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer's disease. / Huang, Meiyan; Yang, Wei; Feng, Qianjin; Chen, Wufan; Weiner, Michael W.; Aisen, Paul; Petersen, Ronald; Jack, Clifford R.; Jagust, William; Trojanowki, John Q.; Toga, Arthur W.; Beckett, Laurel; Green, Robert C.; Saykin, Andrew J.; Morris, John; Shaw, Leslie M.; Kaye, Jeffrey; Quinn, Joseph; Silbert, Lisa; Lind, Betty; Carter, Raina; Dolen, Sara; Schneider, Lon S.; Pawluczyk, Sonia; Beccera, Mauricio; Teodoro, Liberty; Spann, Bryan M.; Brewer, James; Vanderswag, Helen; Fleisher, Adam; Heidebrink, Judith L.; Lord, Joanne L.; Mason, Sara S.; Albers, Colleen S.; Knopman, David; Johnson, Kris; Doody, Rachelle S.; Villanueva-Meyer, Javier; Chowdhury, Munir; Rountree, Susan; Dang, Mimi; Stern, Yaakov; Honig, Lawrence S.; Bell, Karen L.; Ances, Beau; Morris, John C.; Carroll, Maria; Creech, Mary L.; Franklin, Erin; Mintun, Mark A.; Schneider, Stacy; Oliver, Angela; Marson, Daniel; Griffith, Randall; Clark, David; Geldmacher, David; Brockington, John; Roberson, Erik; Love, Marissa Natelson; Grossman, Hillel; Mitsis, Effie; Shah, Raj C.; DeToledo-Morrell, Leyla; Duara, Ranjan; Varon, Daniel; Greig, Maria T.; Albert, Marilyn; Onyike, Chiadikaobi U; Onyike, Chiadi; D'Agostino, Daniel; Kielb, Stephanie; Galvin, James E.; Cerbone, Brittany; Michel, Christina A.; Pogorelec, Dana M.; Rusinek, Henry; De Leon, Mony J.; Glodzik, Lidia; De Santi, Susan; Murali Doraiswamy, P.; Petrella, Jeffrey R.; Borges-Neto, Salvador; Wong, Terence Z.; Coleman, Edward; Smith, Charles D.; Jicha, Greg; Hardy, Peter; Sinha, Partha; Oates, Elizabeth; Conrad, Gary; Porsteinsson, Anton P.; Goldstein, Bonnie S.; Martin, Kim; Makino, Kelly M.; Saleem Ismail, M.; Brand, Connie; Mulnard, Ruth A.; Thai, Gaby; Mc-Adams-Ortiz, Catherine; Womack, Kyle; Mathews, Dana; Quiceno, Mary; Levey, Allan I.; Lah, James J.; Cellar, Janet S.; Burns, Jeffrey M.; Swerdlow, Russell H.; Brooks, William M.; Apostolova, Liana; Tingus, Kathleen; Woo, Ellen; Silverman, Daniel H S; Lu, Po H.; Bartzokis, George; Graff-Radford, Neill R.; Parfitt, Francine; Kendall, Tracy; Johnson, Heather; Farlow, Martin R.; Hake, Ann Marie; Brosch, Jared R.; Herring, Scott; Hunt, Cynthia; Van Dyck, Christopher H.; Carson, Richard E.; MacAvoy, Martha G.; Varma, Pradeep; Chertkow, Howard; Bergman, Howard; Hosein, Chris; Black, Sandra; Stefanovic, Bojana; Caldwell, Curtis; Hsiung, Ging Yuek Robin; Feldman, Howard; Mudge, Benita; Assaly, Michele; Finger, Elizabeth; Pasternack, Stephen; Rachisky, Irina; Trost, Dick; Kertesz, Andrew; Bernick, Charles; Munic, Donna; Mesulam, Marek Marsel; Lipowski, Kristine; Weintraub, Sandra; Bonakdarpour, Borna; Kerwin, Diana; Wu, Chuang Kuo; Johnson, Nancy; Sadowsky, Carl; Villena, Teresa; Turner, Raymond Scott; Johnson, Kathleen; Reynolds, Brigid; Sperling, Reisa A.; Johnson, Keith A.; Marshall, Gad; Yesavage, Jerome; Taylor, Joy L.; Lane, Barton; Rosen, Allyson; Tinklenberg, Jared; Sabbagh, Marwan N.; Belden, Christine M.; Jacobson, Sandra A.; Sirrel, Sherye A.; Kowall, Neil; Killiany, Ronald; Budson, Andrew E.; Norbash, Alexander; Lynn Johnson, Patricia; Obisesan, Thomas O.; Wolday, Saba; Allard, Joanne; Lerner, Alan; Ogrocki, Paula; Tatsuoka, Curtis; Fatica, Parianne; Fletcher, Evan; Maillard, Pauline; Olichney, John; DeCarli, Charles; Carmichael, Owen; Kittur, Smita; Borrie, Michael; Lee, T. Y.; Bartha, Rob; Johnson, Sterling; Asthana, Sanjay; Carlsson, Cynthia M.; Potkin, Steven G.; Preda, Adrian; Nguyen, Dana; Tariot, Pierre; Burke, Anna; Trncic, Nadira; Reeder, Stephanie; Bates, Vernice; Capote, Horacio; Rainka, Michelle; Scharre, Douglas W.; Kataki, Maria; Adeli, Anahita; Zimmerman, Earl A.; Celmins, Dzintra; Brown, Alice D.; Pearlson, Godfrey D.; Blank, Karen; Anderson, Karen; Flashman, Laura A.; Seltzer, Marc; Hynes, Mary L.; Santulli, Robert B.; Sink, Kaycee M.; Gordineer, Leslie; Williamson, Jeff D.; Garg, Pradeep; Watkins, Franklin; Ott, Brian R.; Querfurth, Henry; Tremont, Geoffrey; Salloway, Stephen; Malloy, Paul; Correia, Stephen; Rosen, Howard J.; Miller, Bruce L.; Perry, David; Mintzer, Jacobo; Spicer, Kenneth; Bachman, David; Pomara, Nunzio; Hernando, Raymundo; Sarrael, Antero; Relkin, Norman; Chaing, Gloria; Lin, Michael; Ravdin, Lisa; Smith, Amanda; Raj, Balebail Ashok; Fargher, Kristin.

In: Scientific Reports, Vol. 7, 39880, 12.01.2017.

Research output: Contribution to journalArticle

Huang, M, Yang, W, Feng, Q, Chen, W, Weiner, MW, Aisen, P, Petersen, R, Jack, CR, Jagust, W, Trojanowki, JQ, Toga, AW, Beckett, L, Green, RC, Saykin, AJ, Morris, J, Shaw, LM, Kaye, J, Quinn, J, Silbert, L, Lind, B, Carter, R, Dolen, S, Schneider, LS, Pawluczyk, S, Beccera, M, Teodoro, L, Spann, BM, Brewer, J, Vanderswag, H, Fleisher, A, Heidebrink, JL, Lord, JL, Mason, SS, Albers, CS, Knopman, D, Johnson, K, Doody, RS, Villanueva-Meyer, J, Chowdhury, M, Rountree, S, Dang, M, Stern, Y, Honig, LS, Bell, KL, Ances, B, Morris, JC, Carroll, M, Creech, ML, Franklin, E, Mintun, MA, Schneider, S, Oliver, A, Marson, D, Griffith, R, Clark, D, Geldmacher, D, Brockington, J, Roberson, E, Love, MN, Grossman, H, Mitsis, E, Shah, RC, DeToledo-Morrell, L, Duara, R, Varon, D, Greig, MT, Albert, M, Onyike, CU, Onyike, C, D'Agostino, D, Kielb, S, Galvin, JE, Cerbone, B, Michel, CA, Pogorelec, DM, Rusinek, H, De Leon, MJ, Glodzik, L, De Santi, S, Murali Doraiswamy, P, Petrella, JR, Borges-Neto, S, Wong, TZ, Coleman, E, Smith, CD, Jicha, G, Hardy, P, Sinha, P, Oates, E, Conrad, G, Porsteinsson, AP, Goldstein, BS, Martin, K, Makino, KM, Saleem Ismail, M, Brand, C, Mulnard, RA, Thai, G, Mc-Adams-Ortiz, C, Womack, K, Mathews, D, Quiceno, M, Levey, AI, Lah, JJ, Cellar, JS, Burns, JM, Swerdlow, RH, Brooks, WM, Apostolova, L, Tingus, K, Woo, E, Silverman, DHS, Lu, PH, Bartzokis, G, Graff-Radford, NR, Parfitt, F, Kendall, T, Johnson, H, Farlow, MR, Hake, AM, Brosch, JR, Herring, S, Hunt, C, Van Dyck, CH, Carson, RE, MacAvoy, MG, Varma, P, Chertkow, H, Bergman, H, Hosein, C, Black, S, Stefanovic, B, Caldwell, C, Hsiung, GYR, Feldman, H, Mudge, B, Assaly, M, Finger, E, Pasternack, S, Rachisky, I, Trost, D, Kertesz, A, Bernick, C, Munic, D, Mesulam, MM, Lipowski, K, Weintraub, S, Bonakdarpour, B, Kerwin, D, Wu, CK, Johnson, N, Sadowsky, C, Villena, T, Turner, RS, Johnson, K, Reynolds, B, Sperling, RA, Johnson, KA, Marshall, G, Yesavage, J, Taylor, JL, Lane, B, Rosen, A, Tinklenberg, J, Sabbagh, MN, Belden, CM, Jacobson, SA, Sirrel, SA, Kowall, N, Killiany, R, Budson, AE, Norbash, A, Lynn Johnson, P, Obisesan, TO, Wolday, S, Allard, J, Lerner, A, Ogrocki, P, Tatsuoka, C, Fatica, P, Fletcher, E, Maillard, P, Olichney, J, DeCarli, C, Carmichael, O, Kittur, S, Borrie, M, Lee, TY, Bartha, R, Johnson, S, Asthana, S, Carlsson, CM, Potkin, SG, Preda, A, Nguyen, D, Tariot, P, Burke, A, Trncic, N, Reeder, S, Bates, V, Capote, H, Rainka, M, Scharre, DW, Kataki, M, Adeli, A, Zimmerman, EA, Celmins, D, Brown, AD, Pearlson, GD, Blank, K, Anderson, K, Flashman, LA, Seltzer, M, Hynes, ML, Santulli, RB, Sink, KM, Gordineer, L, Williamson, JD, Garg, P, Watkins, F, Ott, BR, Querfurth, H, Tremont, G, Salloway, S, Malloy, P, Correia, S, Rosen, HJ, Miller, BL, Perry, D, Mintzer, J, Spicer, K, Bachman, D, Pomara, N, Hernando, R, Sarrael, A, Relkin, N, Chaing, G, Lin, M, Ravdin, L, Smith, A, Raj, BA & Fargher, K 2017, 'Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer's disease', Scientific Reports, vol. 7, 39880. https://doi.org/10.1038/srep39880
Huang, Meiyan ; Yang, Wei ; Feng, Qianjin ; Chen, Wufan ; Weiner, Michael W. ; Aisen, Paul ; Petersen, Ronald ; Jack, Clifford R. ; Jagust, William ; Trojanowki, John Q. ; Toga, Arthur W. ; Beckett, Laurel ; Green, Robert C. ; Saykin, Andrew J. ; Morris, John ; Shaw, Leslie M. ; Kaye, Jeffrey ; Quinn, Joseph ; Silbert, Lisa ; Lind, Betty ; Carter, Raina ; Dolen, Sara ; Schneider, Lon S. ; Pawluczyk, Sonia ; Beccera, Mauricio ; Teodoro, Liberty ; Spann, Bryan M. ; Brewer, James ; Vanderswag, Helen ; Fleisher, Adam ; Heidebrink, Judith L. ; Lord, Joanne L. ; Mason, Sara S. ; Albers, Colleen S. ; Knopman, David ; Johnson, Kris ; Doody, Rachelle S. ; Villanueva-Meyer, Javier ; Chowdhury, Munir ; Rountree, Susan ; Dang, Mimi ; Stern, Yaakov ; Honig, Lawrence S. ; Bell, Karen L. ; Ances, Beau ; Morris, John C. ; Carroll, Maria ; Creech, Mary L. ; Franklin, Erin ; Mintun, Mark A. ; Schneider, Stacy ; Oliver, Angela ; Marson, Daniel ; Griffith, Randall ; Clark, David ; Geldmacher, David ; Brockington, John ; Roberson, Erik ; Love, Marissa Natelson ; Grossman, Hillel ; Mitsis, Effie ; Shah, Raj C. ; DeToledo-Morrell, Leyla ; Duara, Ranjan ; Varon, Daniel ; Greig, Maria T. ; Albert, Marilyn ; Onyike, Chiadikaobi U ; Onyike, Chiadi ; D'Agostino, Daniel ; Kielb, Stephanie ; Galvin, James E. ; Cerbone, Brittany ; Michel, Christina A. ; Pogorelec, Dana M. ; Rusinek, Henry ; De Leon, Mony J. ; Glodzik, Lidia ; De Santi, Susan ; Murali Doraiswamy, P. ; Petrella, Jeffrey R. ; Borges-Neto, Salvador ; Wong, Terence Z. ; Coleman, Edward ; Smith, Charles D. ; Jicha, Greg ; Hardy, Peter ; Sinha, Partha ; Oates, Elizabeth ; Conrad, Gary ; Porsteinsson, Anton P. ; Goldstein, Bonnie S. ; Martin, Kim ; Makino, Kelly M. ; Saleem Ismail, M. ; Brand, Connie ; Mulnard, Ruth A. ; Thai, Gaby ; Mc-Adams-Ortiz, Catherine ; Womack, Kyle ; Mathews, Dana ; Quiceno, Mary ; Levey, Allan I. ; Lah, James J. ; Cellar, Janet S. ; Burns, Jeffrey M. ; Swerdlow, Russell H. ; Brooks, William M. ; Apostolova, Liana ; Tingus, Kathleen ; Woo, Ellen ; Silverman, Daniel H S ; Lu, Po H. ; Bartzokis, George ; Graff-Radford, Neill R. ; Parfitt, Francine ; Kendall, Tracy ; Johnson, Heather ; Farlow, Martin R. ; Hake, Ann Marie ; Brosch, Jared R. ; Herring, Scott ; Hunt, Cynthia ; Van Dyck, Christopher H. ; Carson, Richard E. ; MacAvoy, Martha G. ; Varma, Pradeep ; Chertkow, Howard ; Bergman, Howard ; Hosein, Chris ; Black, Sandra ; Stefanovic, Bojana ; Caldwell, Curtis ; Hsiung, Ging Yuek Robin ; Feldman, Howard ; Mudge, Benita ; Assaly, Michele ; Finger, Elizabeth ; Pasternack, Stephen ; Rachisky, Irina ; Trost, Dick ; Kertesz, Andrew ; Bernick, Charles ; Munic, Donna ; Mesulam, Marek Marsel ; Lipowski, Kristine ; Weintraub, Sandra ; Bonakdarpour, Borna ; Kerwin, Diana ; Wu, Chuang Kuo ; Johnson, Nancy ; Sadowsky, Carl ; Villena, Teresa ; Turner, Raymond Scott ; Johnson, Kathleen ; Reynolds, Brigid ; Sperling, Reisa A. ; Johnson, Keith A. ; Marshall, Gad ; Yesavage, Jerome ; Taylor, Joy L. ; Lane, Barton ; Rosen, Allyson ; Tinklenberg, Jared ; Sabbagh, Marwan N. ; Belden, Christine M. ; Jacobson, Sandra A. ; Sirrel, Sherye A. ; Kowall, Neil ; Killiany, Ronald ; Budson, Andrew E. ; Norbash, Alexander ; Lynn Johnson, Patricia ; Obisesan, Thomas O. ; Wolday, Saba ; Allard, Joanne ; Lerner, Alan ; Ogrocki, Paula ; Tatsuoka, Curtis ; Fatica, Parianne ; Fletcher, Evan ; Maillard, Pauline ; Olichney, John ; DeCarli, Charles ; Carmichael, Owen ; Kittur, Smita ; Borrie, Michael ; Lee, T. Y. ; Bartha, Rob ; Johnson, Sterling ; Asthana, Sanjay ; Carlsson, Cynthia M. ; Potkin, Steven G. ; Preda, Adrian ; Nguyen, Dana ; Tariot, Pierre ; Burke, Anna ; Trncic, Nadira ; Reeder, Stephanie ; Bates, Vernice ; Capote, Horacio ; Rainka, Michelle ; Scharre, Douglas W. ; Kataki, Maria ; Adeli, Anahita ; Zimmerman, Earl A. ; Celmins, Dzintra ; Brown, Alice D. ; Pearlson, Godfrey D. ; Blank, Karen ; Anderson, Karen ; Flashman, Laura A. ; Seltzer, Marc ; Hynes, Mary L. ; Santulli, Robert B. ; Sink, Kaycee M. ; Gordineer, Leslie ; Williamson, Jeff D. ; Garg, Pradeep ; Watkins, Franklin ; Ott, Brian R. ; Querfurth, Henry ; Tremont, Geoffrey ; Salloway, Stephen ; Malloy, Paul ; Correia, Stephen ; Rosen, Howard J. ; Miller, Bruce L. ; Perry, David ; Mintzer, Jacobo ; Spicer, Kenneth ; Bachman, David ; Pomara, Nunzio ; Hernando, Raymundo ; Sarrael, Antero ; Relkin, Norman ; Chaing, Gloria ; Lin, Michael ; Ravdin, Lisa ; Smith, Amanda ; Raj, Balebail Ashok ; Fargher, Kristin. / Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer's disease. In: Scientific Reports. 2017 ; Vol. 7.
@article{88b6ebbca1444b23a073c7468ca6b82b,
title = "Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer's disease",
abstract = "Accurate prediction of Alzheimer's disease (AD) is important for the early diagnosis and treatment of this condition. Mild cognitive impairment (MCI) is an early stage of AD. Therefore, patients with MCI who are at high risk of fully developing AD should be identified to accurately predict AD. However, the relationship between brain images and AD is difficult to construct because of the complex characteristics of neuroimaging data. To address this problem, we present a longitudinal measurement of MCI brain images and a hierarchical classification method for AD prediction. Longitudinal images obtained from individuals with MCI were investigated to acquire important information on the longitudinal changes, which can be used to classify MCI subjects as either MCI conversion (MCIc) or MCI non-conversion (MCInc) individuals. Moreover, a hierarchical framework was introduced to the classifier to manage high feature dimensionality issues and incorporate spatial information for improving the prediction accuracy. The proposed method was evaluated using 131 patients with MCI (70 MCIc and 61 MCInc) based on MRI scans taken at different time points. Results showed that the proposed method achieved 79.4{\%} accuracy for the classification of MCIc versus MCInc, thereby demonstrating very promising performance for AD prediction.",
author = "Meiyan Huang and Wei Yang and Qianjin Feng and Wufan Chen and Weiner, {Michael W.} and Paul Aisen and Ronald Petersen and Jack, {Clifford R.} and William Jagust and Trojanowki, {John Q.} and Toga, {Arthur W.} and Laurel Beckett and Green, {Robert C.} and Saykin, {Andrew J.} and John Morris and Shaw, {Leslie M.} and Jeffrey Kaye and Joseph Quinn and Lisa Silbert and Betty Lind and Raina Carter and Sara Dolen and Schneider, {Lon S.} and Sonia Pawluczyk and Mauricio Beccera and Liberty Teodoro and Spann, {Bryan M.} and James Brewer and Helen Vanderswag and Adam Fleisher and Heidebrink, {Judith L.} and Lord, {Joanne L.} and Mason, {Sara S.} and Albers, {Colleen S.} and David Knopman and Kris Johnson and Doody, {Rachelle S.} and Javier Villanueva-Meyer and Munir Chowdhury and Susan Rountree and Mimi Dang and Yaakov Stern and Honig, {Lawrence S.} and Bell, {Karen L.} and Beau Ances and Morris, {John C.} and Maria Carroll and Creech, {Mary L.} and Erin Franklin and Mintun, {Mark A.} and Stacy Schneider and Angela Oliver and Daniel Marson and Randall Griffith and David Clark and David Geldmacher and John Brockington and Erik Roberson and Love, {Marissa Natelson} and Hillel Grossman and Effie Mitsis and Shah, {Raj C.} and Leyla DeToledo-Morrell and Ranjan Duara and Daniel Varon and Greig, {Maria T.} and Marilyn Albert and Onyike, {Chiadikaobi U} and Chiadi Onyike and Daniel D'Agostino and Stephanie Kielb and Galvin, {James E.} and Brittany Cerbone and Michel, {Christina A.} and Pogorelec, {Dana M.} and Henry Rusinek and {De Leon}, {Mony J.} and Lidia Glodzik and {De Santi}, Susan and {Murali Doraiswamy}, P. and Petrella, {Jeffrey R.} and Salvador Borges-Neto and Wong, {Terence Z.} and Edward Coleman and Smith, {Charles D.} and Greg Jicha and Peter Hardy and Partha Sinha and Elizabeth Oates and Gary Conrad and Porsteinsson, {Anton P.} and Goldstein, {Bonnie S.} and Kim Martin and Makino, {Kelly M.} and {Saleem Ismail}, M. and Connie Brand and Mulnard, {Ruth A.} and Gaby Thai and Catherine Mc-Adams-Ortiz and Kyle Womack and Dana Mathews and Mary Quiceno and Levey, {Allan I.} and Lah, {James J.} and Cellar, {Janet S.} and Burns, {Jeffrey M.} and Swerdlow, {Russell H.} and Brooks, {William M.} and Liana Apostolova and Kathleen Tingus and Ellen Woo and Silverman, {Daniel H S} and Lu, {Po H.} and George Bartzokis and Graff-Radford, {Neill R.} and Francine Parfitt and Tracy Kendall and Heather Johnson and Farlow, {Martin R.} and Hake, {Ann Marie} and Brosch, {Jared R.} and Scott Herring and Cynthia Hunt and {Van Dyck}, {Christopher H.} and Carson, {Richard E.} and MacAvoy, {Martha G.} and Pradeep Varma and Howard Chertkow and Howard Bergman and Chris Hosein and Sandra Black and Bojana Stefanovic and Curtis Caldwell and Hsiung, {Ging Yuek Robin} and Howard Feldman and Benita Mudge and Michele Assaly and Elizabeth Finger and Stephen Pasternack and Irina Rachisky and Dick Trost and Andrew Kertesz and Charles Bernick and Donna Munic and Mesulam, {Marek Marsel} and Kristine Lipowski and Sandra Weintraub and Borna Bonakdarpour and Diana Kerwin and Wu, {Chuang Kuo} and Nancy Johnson and Carl Sadowsky and Teresa Villena and Turner, {Raymond Scott} and Kathleen Johnson and Brigid Reynolds and Sperling, {Reisa A.} and Johnson, {Keith A.} and Gad Marshall and Jerome Yesavage and Taylor, {Joy L.} and Barton Lane and Allyson Rosen and Jared Tinklenberg and Sabbagh, {Marwan N.} and Belden, {Christine M.} and Jacobson, {Sandra A.} and Sirrel, {Sherye A.} and Neil Kowall and Ronald Killiany and Budson, {Andrew E.} and Alexander Norbash and {Lynn Johnson}, Patricia and Obisesan, {Thomas O.} and Saba Wolday and Joanne Allard and Alan Lerner and Paula Ogrocki and Curtis Tatsuoka and Parianne Fatica and Evan Fletcher and Pauline Maillard and John Olichney and Charles DeCarli and Owen Carmichael and Smita Kittur and Michael Borrie and Lee, {T. Y.} and Rob Bartha and Sterling Johnson and Sanjay Asthana and Carlsson, {Cynthia M.} and Potkin, {Steven G.} and Adrian Preda and Dana Nguyen and Pierre Tariot and Anna Burke and Nadira Trncic and Stephanie Reeder and Vernice Bates and Horacio Capote and Michelle Rainka and Scharre, {Douglas W.} and Maria Kataki and Anahita Adeli and Zimmerman, {Earl A.} and Dzintra Celmins and Brown, {Alice D.} and Pearlson, {Godfrey D.} and Karen Blank and Karen Anderson and Flashman, {Laura A.} and Marc Seltzer and Hynes, {Mary L.} and Santulli, {Robert B.} and Sink, {Kaycee M.} and Leslie Gordineer and Williamson, {Jeff D.} and Pradeep Garg and Franklin Watkins and Ott, {Brian R.} and Henry Querfurth and Geoffrey Tremont and Stephen Salloway and Paul Malloy and Stephen Correia and Rosen, {Howard J.} and Miller, {Bruce L.} and David Perry and Jacobo Mintzer and Kenneth Spicer and David Bachman and Nunzio Pomara and Raymundo Hernando and Antero Sarrael and Norman Relkin and Gloria Chaing and Michael Lin and Lisa Ravdin and Amanda Smith and Raj, {Balebail Ashok} and Kristin Fargher",
year = "2017",
month = "1",
day = "12",
doi = "10.1038/srep39880",
language = "English (US)",
volume = "7",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer's disease

AU - Huang, Meiyan

AU - Yang, Wei

AU - Feng, Qianjin

AU - Chen, Wufan

AU - Weiner, Michael W.

AU - Aisen, Paul

AU - Petersen, Ronald

AU - Jack, Clifford R.

AU - Jagust, William

AU - Trojanowki, John Q.

AU - Toga, Arthur W.

AU - Beckett, Laurel

AU - Green, Robert C.

AU - Saykin, Andrew J.

AU - Morris, John

AU - Shaw, Leslie M.

AU - Kaye, Jeffrey

AU - Quinn, Joseph

AU - Silbert, Lisa

AU - Lind, Betty

AU - Carter, Raina

AU - Dolen, Sara

AU - Schneider, Lon S.

AU - Pawluczyk, Sonia

AU - Beccera, Mauricio

AU - Teodoro, Liberty

AU - Spann, Bryan M.

AU - Brewer, James

AU - Vanderswag, Helen

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AU - Raj, Balebail Ashok

AU - Fargher, Kristin

PY - 2017/1/12

Y1 - 2017/1/12

N2 - Accurate prediction of Alzheimer's disease (AD) is important for the early diagnosis and treatment of this condition. Mild cognitive impairment (MCI) is an early stage of AD. Therefore, patients with MCI who are at high risk of fully developing AD should be identified to accurately predict AD. However, the relationship between brain images and AD is difficult to construct because of the complex characteristics of neuroimaging data. To address this problem, we present a longitudinal measurement of MCI brain images and a hierarchical classification method for AD prediction. Longitudinal images obtained from individuals with MCI were investigated to acquire important information on the longitudinal changes, which can be used to classify MCI subjects as either MCI conversion (MCIc) or MCI non-conversion (MCInc) individuals. Moreover, a hierarchical framework was introduced to the classifier to manage high feature dimensionality issues and incorporate spatial information for improving the prediction accuracy. The proposed method was evaluated using 131 patients with MCI (70 MCIc and 61 MCInc) based on MRI scans taken at different time points. Results showed that the proposed method achieved 79.4% accuracy for the classification of MCIc versus MCInc, thereby demonstrating very promising performance for AD prediction.

AB - Accurate prediction of Alzheimer's disease (AD) is important for the early diagnosis and treatment of this condition. Mild cognitive impairment (MCI) is an early stage of AD. Therefore, patients with MCI who are at high risk of fully developing AD should be identified to accurately predict AD. However, the relationship between brain images and AD is difficult to construct because of the complex characteristics of neuroimaging data. To address this problem, we present a longitudinal measurement of MCI brain images and a hierarchical classification method for AD prediction. Longitudinal images obtained from individuals with MCI were investigated to acquire important information on the longitudinal changes, which can be used to classify MCI subjects as either MCI conversion (MCIc) or MCI non-conversion (MCInc) individuals. Moreover, a hierarchical framework was introduced to the classifier to manage high feature dimensionality issues and incorporate spatial information for improving the prediction accuracy. The proposed method was evaluated using 131 patients with MCI (70 MCIc and 61 MCInc) based on MRI scans taken at different time points. Results showed that the proposed method achieved 79.4% accuracy for the classification of MCIc versus MCInc, thereby demonstrating very promising performance for AD prediction.

UR - http://www.scopus.com/inward/record.url?scp=85009350821&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85009350821&partnerID=8YFLogxK

U2 - 10.1038/srep39880

DO - 10.1038/srep39880

M3 - Article

C2 - 28079104

AN - SCOPUS:85009350821

VL - 7

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 39880

ER -