Longitudinal evaluation of transport kinetics in children receiving peritoneal dialysis

Bradley A. Warady, Barbara A Fivush, Sharon P. Andreoli, Edward Kohaut, Isidro Salusky, Linda Schlichting, Kewei Pu, Sandra Watkins

Research output: Contribution to journalArticle

Abstract

Functional stability of the peritoneal membrane is necessary for maintenance of peritoneal dialysis (PD) as a therapeutic option. Few studies have investigated this issue in children. We evaluated the peritoneal membrane solute transport capacity longitudinally in 26 children (mean age 11.0 ± 5.5 years) receiving long-term PD. Each patient underwent a standardized peritoneal equilibration test on two occasions (mean interval between studies 19.8 ± 5.9 months) to determine solute dialysate to plasma (D/P) ratios, dialysate glucose to initial dialysate glucose (D/D0) ratios, and mass transfer area coefficients (MTAC). The correlation of transport capacity with peritonitis history was also assessed. No significant change in MTAC, D/P, or D/D0 values were found when comparing original and follow-up data of the group overall. However, transport of creatinine and glucose was significantly (P <0.05) greater in the peritonitis group compared with the group without peritonitis, and differences in the change over time between the peritonitis groups was significant for MTAC creatinine (P = 0.035) and D/D0 glucose (P = 0.020). In summary, this experience demonstrates functional stability of the peritoneal membrane in pediatric patients receiving PD. However, follow-up assessments of peritoneal solute kinetics may be necessary in patients with a history of peritonitis in order to permit early identification of those who may be at risk for ultrafiltration failure and sclerosing peritonitis.

Original languageEnglish (US)
Pages (from-to)571-576
Number of pages6
JournalPediatric Nephrology
Volume13
Issue number7
DOIs
Publication statusPublished - Sep 1999

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Keywords

  • Kinetics
  • Peritoneal dialysis
  • Peritoneal equilibration test
  • Peritonitis
  • Transport

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Warady, B. A., Fivush, B. A., Andreoli, S. P., Kohaut, E., Salusky, I., Schlichting, L., ... Watkins, S. (1999). Longitudinal evaluation of transport kinetics in children receiving peritoneal dialysis. Pediatric Nephrology, 13(7), 571-576. https://doi.org/10.1007/s004670050745