Longitudinal evaluation of transport kinetics in children receiving peritoneal dialysis

Bradley A. Warady, Barbara Fivush, Sharon P. Andreoli, Edward Kohaut, Isidro Salusky, Linda Schlichting, Kewei Pu, Sandra Watkins

Research output: Contribution to journalArticle

Abstract

Functional stability of the peritoneal membrane is necessary for maintenance of peritoneal dialysis (PD) as a therapeutic option. Few studies have investigated this issue in children. We evaluated the peritoneal membrane solute transport capacity longitudinally in 26 children (mean age 11.0 ± 5.5 years) receiving long-term PD. Each patient underwent a standardized peritoneal equilibration test on two occasions (mean interval between studies 19.8 ± 5.9 months) to determine solute dialysate to plasma (D/P) ratios, dialysate glucose to initial dialysate glucose (D/D0) ratios, and mass transfer area coefficients (MTAC). The correlation of transport capacity with peritonitis history was also assessed. No significant change in MTAC, D/P, or D/D0 values were found when comparing original and follow-up data of the group overall. However, transport of creatinine and glucose was significantly (P < 0.05) greater in the peritonitis group compared with the group without peritonitis, and differences in the change over time between the peritonitis groups was significant for MTAC creatinine (P = 0.035) and D/D0 glucose (P = 0.020). In summary, this experience demonstrates functional stability of the peritoneal membrane in pediatric patients receiving PD. However, follow-up assessments of peritoneal solute kinetics may be necessary in patients with a history of peritonitis in order to permit early identification of those who may be at risk for ultrafiltration failure and sclerosing peritonitis.

Original languageEnglish (US)
Pages (from-to)571-576
Number of pages6
JournalPediatric Nephrology
Volume13
Issue number7
DOIs
StatePublished - Sep 1 1999

Keywords

  • Kinetics
  • Peritoneal dialysis
  • Peritoneal equilibration test
  • Peritonitis
  • Transport

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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    Warady, B. A., Fivush, B., Andreoli, S. P., Kohaut, E., Salusky, I., Schlichting, L., Pu, K., & Watkins, S. (1999). Longitudinal evaluation of transport kinetics in children receiving peritoneal dialysis. Pediatric Nephrology, 13(7), 571-576. https://doi.org/10.1007/s004670050745