Longitudinal evaluation of surrogates of regional cerebral blood flow computed from dynamic amyloid PET imaging

Murat Bilgel, Lori Beason-Held, Yang An, Yun Zhou, Dean Foster Wong, Susan M. Resnick

Research output: Contribution to journalArticle

Abstract

Surrogates of neuronal activity, typically measured by regional cerebral blood flow (rCBF) or glucose metabolism, can be estimated from dynamic amyloid PET imaging. Using data for 149 participants (345 visits) from the Baltimore Longitudinal Study of Aging, we assessed whether the average of early amyloid frames (EA) and R 1 computed from dynamic 11 C-Pittsburgh compound B (PiB) PET can serve as surrogates of rCBF computed from 15 O-H 2 O-PET. R 1 had the highest longitudinal test–retest reliability. Interquartile range (IQR) of cross-sectional Pearson correlations with rCBF was 0.60–0.72 for EA and 0.63–0.72 for R 1 . Correlations between rates of change were lower (IQR 0.22–0.50 for EA, 0.25–0.55 for R 1 ). Values in the Alzheimer’s metabolic signature meta-ROI were negatively associated with age and exhibited longitudinal declines for each PET measure. In age-adjusted analyses, meta-ROI rCBF and R 1 were lower among amyloid+ individuals; EA and R 1 were lower among males. Regional PiB-based measures, in particular R 1 , can be suitable surrogates of rCBF. Dynamic PiB-PET may obviate the need for a separate scan to measure neuronal activity, thereby reducing patient burden, radioactivity exposure, and cost.

Original languageEnglish (US)
JournalJournal of Cerebral Blood Flow and Metabolism
DOIs
StatePublished - Jan 1 2019

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Cerebrovascular Circulation
Regional Blood Flow
Amyloid
Baltimore
Radioactivity
Longitudinal Studies
Costs and Cost Analysis
Glucose

Keywords

  • Amyloid
  • cerebral blood flow
  • longitudinal
  • neurodegeneration
  • neuronal activity

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Longitudinal evaluation of surrogates of regional cerebral blood flow computed from dynamic amyloid PET imaging. / Bilgel, Murat; Beason-Held, Lori; An, Yang; Zhou, Yun; Wong, Dean Foster; Resnick, Susan M.

In: Journal of Cerebral Blood Flow and Metabolism, 01.01.2019.

Research output: Contribution to journalArticle

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