Longitudinal Evaluation of Prostate-Specific Antigen Levels in Men With and Without Prostate Disease

H Ballentine Carter, Patrick Walsh, Daniel Wan-Yui Chan, Reubin Andres, James L. Fozard

Research output: Contribution to journalArticle

Abstract

Objective. ——To evaluate longitudinal changes in prostate-specific antigen (PSA) levels in men with and without prostate disease. Design. —Case-control study of men with and without prostate disease who were participants in a prospective aging study. Setting. —Gerontology Research Center of the National Institute on Aging; the Baltimore (Md) Longitudinal Study of Aging. Patients. —Sixteen men with no prostate disease (control group), 20 men with a histologic diagnosis of benign prostatic hyperplasia (BPH), and 18 men with a histologic diagnosis of prostate cancer. Outcome Measures. —Multiple PSA and androgen determinations on serum samples obtained from 7 to 25 years prior to histologic diagnosis or exclusion of prostate disease. Results. —Changes in androgen levels with age did not differ between groups. Control subjects did not show a significant change in PSA levels with age. There was a significant difference in the age-adjusted rate of change in PSA levels between groups (prostate cancer>BPH>control; P

Original languageEnglish (US)
Pages (from-to)2215-2220
Number of pages6
JournalJournal of the American Medical Association
Volume267
Issue number16
DOIs
StatePublished - Apr 22 1992

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Prostate-Specific Antigen
Prostate
Prostatic Hyperplasia
Androgens
Prostatic Neoplasms
National Institute on Aging (U.S.)
Baltimore
Geriatrics
Longitudinal Studies
Case-Control Studies
Outcome Assessment (Health Care)
Prospective Studies
Control Groups
Serum
Research

ASJC Scopus subject areas

  • Medicine(all)

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Longitudinal Evaluation of Prostate-Specific Antigen Levels in Men With and Without Prostate Disease. / Carter, H Ballentine; Walsh, Patrick; Chan, Daniel Wan-Yui; Andres, Reubin; Fozard, James L.

In: Journal of the American Medical Association, Vol. 267, No. 16, 22.04.1992, p. 2215-2220.

Research output: Contribution to journalArticle

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abstract = "Objective. ——To evaluate longitudinal changes in prostate-specific antigen (PSA) levels in men with and without prostate disease. Design. —Case-control study of men with and without prostate disease who were participants in a prospective aging study. Setting. —Gerontology Research Center of the National Institute on Aging; the Baltimore (Md) Longitudinal Study of Aging. Patients. —Sixteen men with no prostate disease (control group), 20 men with a histologic diagnosis of benign prostatic hyperplasia (BPH), and 18 men with a histologic diagnosis of prostate cancer. Outcome Measures. —Multiple PSA and androgen determinations on serum samples obtained from 7 to 25 years prior to histologic diagnosis or exclusion of prostate disease. Results. —Changes in androgen levels with age did not differ between groups. Control subjects did not show a significant change in PSA levels with age. There was a significant difference in the age-adjusted rate of change in PSA levels between groups (prostate cancer>BPH>control; P",
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