Longitudinal evaluation of clustering of chronic sinonasal and related symptoms using exploratory factor analysis

M. Cole, Karen J Bandeen Roche, A. G. Hirsch, J. R. Kuiper, A. S. Sundaresan, B. K. Tan, R. P. Schleimer, R. C. Kern, Brian S Schwartz

Research output: Contribution to journalArticle

Abstract

Background: Sinonasal symptoms are common and can have several underlying causes. When symptoms occur in specified patterns lasting 3 months or more they meet criteria for chronic rhinosinusitis (CRS). Approaches to CRS symptom measurement do not specify how to measure symptoms and treat specified sinonasal symptoms as generally interchangeable, suggesting that such symptoms should cluster on 1 or 2 latent factors. Methods: We used questionnaire responses to 37 questions on the presence, severity, bother, and frequency of cardinal sinonasal and related symptoms lasting 3 months, from 3535 subjects at 3 time points over 16 months. We completed 5 exploratory factor analyses (EFA) to identify symptom clustering, 1 for each time point and 2 for the differences between adjacent questionnaires. The baseline EFA was used to provide factor scores that were described longitudinally and examined by CRS status. Results: Five EFAs identified the same 5 factors (blockage and discharge, pain and pressure, asthma and cold/flu symptoms, smell loss, and ear and eye [mainly allergy] symptoms), with clustering determined by symptom frequency, severity, and degree of bother. Responses to individual questions showed changes over time but when combined into factor scores showed less longitudinal change. All symptom factor scores were progressively higher from never to past to current CRS status. Conclusions: Although the current approaches to symptom characterization in CRS imply a single underlying latent construct, our results suggest that there are at least 3 latent constructs relevant to CRS. Further studies are needed to evaluate whether these clusters have identifiable underlying pathobiologies.

Original languageEnglish (US)
JournalAllergy: European Journal of Allergy and Clinical Immunology
DOIs
StateAccepted/In press - Jan 1 2018

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Statistical Factor Analysis
Cluster Analysis
Smell
Ear
Hypersensitivity
Asthma
Pressure
Pain
Surveys and Questionnaires

Keywords

  • Chronic rhinosinusitis
  • Exploratory factor analysis
  • Longitudinal
  • Nasal and sinus symptoms
  • Population-based epidemiology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Longitudinal evaluation of clustering of chronic sinonasal and related symptoms using exploratory factor analysis. / Cole, M.; Bandeen Roche, Karen J; Hirsch, A. G.; Kuiper, J. R.; Sundaresan, A. S.; Tan, B. K.; Schleimer, R. P.; Kern, R. C.; Schwartz, Brian S.

In: Allergy: European Journal of Allergy and Clinical Immunology, 01.01.2018.

Research output: Contribution to journalArticle

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AU - Sundaresan, A. S.

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AB - Background: Sinonasal symptoms are common and can have several underlying causes. When symptoms occur in specified patterns lasting 3 months or more they meet criteria for chronic rhinosinusitis (CRS). Approaches to CRS symptom measurement do not specify how to measure symptoms and treat specified sinonasal symptoms as generally interchangeable, suggesting that such symptoms should cluster on 1 or 2 latent factors. Methods: We used questionnaire responses to 37 questions on the presence, severity, bother, and frequency of cardinal sinonasal and related symptoms lasting 3 months, from 3535 subjects at 3 time points over 16 months. We completed 5 exploratory factor analyses (EFA) to identify symptom clustering, 1 for each time point and 2 for the differences between adjacent questionnaires. The baseline EFA was used to provide factor scores that were described longitudinally and examined by CRS status. Results: Five EFAs identified the same 5 factors (blockage and discharge, pain and pressure, asthma and cold/flu symptoms, smell loss, and ear and eye [mainly allergy] symptoms), with clustering determined by symptom frequency, severity, and degree of bother. Responses to individual questions showed changes over time but when combined into factor scores showed less longitudinal change. All symptom factor scores were progressively higher from never to past to current CRS status. Conclusions: Although the current approaches to symptom characterization in CRS imply a single underlying latent construct, our results suggest that there are at least 3 latent constructs relevant to CRS. Further studies are needed to evaluate whether these clusters have identifiable underlying pathobiologies.

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