Longitudinal course of behavioral problems during Alzheimer's disease: Linear versus curvilinear patterns of decline

Harry J. McCarty, David L Roth, Kathryn T. Goode, Jason E. Owen, Lindy Harrell, Kristine Donovan, William E. Haley

Research output: Contribution to journalArticle

Abstract

Background. Patients with Alzheimer's Disease (AD) are commonly assumed to experience a linear decline in behavioral functioning that parallels progressive cognitive decline. However, some researchers have suggested that specific behavioral problems either decline at different rates or improve in late dementia. Methods. The present analyses examined 150 AD patients at an initial assessment, 61 of whom were also evaluated annually on two additional occasions. Measures of cognitive impairment and behavioral problems were obtained. Results. Cross-sectional results indicated curvilinear associations between dementia severity and certain behavioral problems (forgetful behaviors, and emotional and impulsive behaviors). Longitudinal analyses further indicated trends for curvilinear rates of behavioral disturbance across time, with some problem areas showing improvement as AD progresses through the most severe stages. Conclusions. Even though Alzheimer's disease is a progressive dementia characterized by increasing cognitive deterioration, it appears to be inaccurate to expect behavioral functioning to show the same linear decline across time.

Original languageEnglish (US)
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume55
Issue number4
StatePublished - Apr 2000
Externally publishedYes

Fingerprint

Alzheimer Disease
Dementia
Impulsive Behavior
Research Personnel
Problem Behavior
Cognitive Dysfunction

ASJC Scopus subject areas

  • Aging

Cite this

Longitudinal course of behavioral problems during Alzheimer's disease : Linear versus curvilinear patterns of decline. / McCarty, Harry J.; Roth, David L; Goode, Kathryn T.; Owen, Jason E.; Harrell, Lindy; Donovan, Kristine; Haley, William E.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 55, No. 4, 04.2000.

Research output: Contribution to journalArticle

McCarty, Harry J. ; Roth, David L ; Goode, Kathryn T. ; Owen, Jason E. ; Harrell, Lindy ; Donovan, Kristine ; Haley, William E. / Longitudinal course of behavioral problems during Alzheimer's disease : Linear versus curvilinear patterns of decline. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2000 ; Vol. 55, No. 4.
@article{b76b9b36f7bd4c0e8d541f9320d13e1e,
title = "Longitudinal course of behavioral problems during Alzheimer's disease: Linear versus curvilinear patterns of decline",
abstract = "Background. Patients with Alzheimer's Disease (AD) are commonly assumed to experience a linear decline in behavioral functioning that parallels progressive cognitive decline. However, some researchers have suggested that specific behavioral problems either decline at different rates or improve in late dementia. Methods. The present analyses examined 150 AD patients at an initial assessment, 61 of whom were also evaluated annually on two additional occasions. Measures of cognitive impairment and behavioral problems were obtained. Results. Cross-sectional results indicated curvilinear associations between dementia severity and certain behavioral problems (forgetful behaviors, and emotional and impulsive behaviors). Longitudinal analyses further indicated trends for curvilinear rates of behavioral disturbance across time, with some problem areas showing improvement as AD progresses through the most severe stages. Conclusions. Even though Alzheimer's disease is a progressive dementia characterized by increasing cognitive deterioration, it appears to be inaccurate to expect behavioral functioning to show the same linear decline across time.",
author = "McCarty, {Harry J.} and Roth, {David L} and Goode, {Kathryn T.} and Owen, {Jason E.} and Lindy Harrell and Kristine Donovan and Haley, {William E.}",
year = "2000",
month = "4",
language = "English (US)",
volume = "55",
journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",
issn = "1079-5006",
publisher = "Oxford University Press",
number = "4",

}

TY - JOUR

T1 - Longitudinal course of behavioral problems during Alzheimer's disease

T2 - Linear versus curvilinear patterns of decline

AU - McCarty, Harry J.

AU - Roth, David L

AU - Goode, Kathryn T.

AU - Owen, Jason E.

AU - Harrell, Lindy

AU - Donovan, Kristine

AU - Haley, William E.

PY - 2000/4

Y1 - 2000/4

N2 - Background. Patients with Alzheimer's Disease (AD) are commonly assumed to experience a linear decline in behavioral functioning that parallels progressive cognitive decline. However, some researchers have suggested that specific behavioral problems either decline at different rates or improve in late dementia. Methods. The present analyses examined 150 AD patients at an initial assessment, 61 of whom were also evaluated annually on two additional occasions. Measures of cognitive impairment and behavioral problems were obtained. Results. Cross-sectional results indicated curvilinear associations between dementia severity and certain behavioral problems (forgetful behaviors, and emotional and impulsive behaviors). Longitudinal analyses further indicated trends for curvilinear rates of behavioral disturbance across time, with some problem areas showing improvement as AD progresses through the most severe stages. Conclusions. Even though Alzheimer's disease is a progressive dementia characterized by increasing cognitive deterioration, it appears to be inaccurate to expect behavioral functioning to show the same linear decline across time.

AB - Background. Patients with Alzheimer's Disease (AD) are commonly assumed to experience a linear decline in behavioral functioning that parallels progressive cognitive decline. However, some researchers have suggested that specific behavioral problems either decline at different rates or improve in late dementia. Methods. The present analyses examined 150 AD patients at an initial assessment, 61 of whom were also evaluated annually on two additional occasions. Measures of cognitive impairment and behavioral problems were obtained. Results. Cross-sectional results indicated curvilinear associations between dementia severity and certain behavioral problems (forgetful behaviors, and emotional and impulsive behaviors). Longitudinal analyses further indicated trends for curvilinear rates of behavioral disturbance across time, with some problem areas showing improvement as AD progresses through the most severe stages. Conclusions. Even though Alzheimer's disease is a progressive dementia characterized by increasing cognitive deterioration, it appears to be inaccurate to expect behavioral functioning to show the same linear decline across time.

UR - http://www.scopus.com/inward/record.url?scp=0034014823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034014823&partnerID=8YFLogxK

M3 - Article

C2 - 10811149

AN - SCOPUS:0034014823

VL - 55

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

SN - 1079-5006

IS - 4

ER -