Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time

Kimberly A. Skarupski, Christine Tangney, Hong Li, Bichun Ouyang, Denis A. Evans, Martha Clare Morris

Research output: Contribution to journalArticle

Abstract

Background: B-vitamin deficiencies have been associated with depression; however, there is very little prospective evidence from population-based studies of older adults. Objective: We examined whether dietary intakes of vitamins B-6, folate, or vitamin B-12 were predictive of depressive symptoms over an average of 7.2 y in a community-based population of older adults. Design: The study sample consisted of 3503 adults from the Chicago Health and Aging project, an ongoing, population-based, biracial (59% African American) study in adults aged ≥65 y. Dietary assessment was made by food-frequency questionnaire. Incident depression was measured by the presence of ≥4 depressive symptoms from the 10-item version of the Center for Epidemiologic Studies Depression scale. Results: The logistic regression models, which used generalized estimating equations, showed that higher total intakes, which included supplementation, of vitamins B-6 and B-12 were associated with a decreased likelihood of incident depression for up to 12 y of follow-up, after adjustment for age, sex, race, education, income, and antidepressant medication use. For example, each 10 additional milligrams of vitamin B-6 and 10 additional micrograms of vitamin B-12 were associated with 2% lower odds of depressive symptoms per year. There was no association between depressive symptoms and food intakes of these vitamins or folate. These associations remained after adjustment for smoking, alcohol use, widowhood, caregiving status, cognitive function, physical disability, and medical conditions. Conclusion: Our results support the hypotheses that high total intakes of vitamins B-6 and B-12 are protective of depressive symptoms over time in community-residing older adults.

Original languageEnglish (US)
Pages (from-to)330-335
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Volume92
Issue number2
DOIs
StatePublished - Aug 1 2010
Externally publishedYes

Fingerprint

Vitamin B 6
Vitamin B 12
Folic Acid
Depression
Vitamin B Deficiency
Logistic Models
Population
Widowhood
Sex Education
Vitamins
African Americans
Cognition
Antidepressive Agents
Epidemiologic Studies
Eating
Smoking
Alcohols
Food
Health

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time. / Skarupski, Kimberly A.; Tangney, Christine; Li, Hong; Ouyang, Bichun; Evans, Denis A.; Morris, Martha Clare.

In: American Journal of Clinical Nutrition, Vol. 92, No. 2, 01.08.2010, p. 330-335.

Research output: Contribution to journalArticle

Skarupski, Kimberly A. ; Tangney, Christine ; Li, Hong ; Ouyang, Bichun ; Evans, Denis A. ; Morris, Martha Clare. / Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time. In: American Journal of Clinical Nutrition. 2010 ; Vol. 92, No. 2. pp. 330-335.
@article{3e1f516ffa284e0a838d7f126284699d,
title = "Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time",
abstract = "Background: B-vitamin deficiencies have been associated with depression; however, there is very little prospective evidence from population-based studies of older adults. Objective: We examined whether dietary intakes of vitamins B-6, folate, or vitamin B-12 were predictive of depressive symptoms over an average of 7.2 y in a community-based population of older adults. Design: The study sample consisted of 3503 adults from the Chicago Health and Aging project, an ongoing, population-based, biracial (59{\%} African American) study in adults aged ≥65 y. Dietary assessment was made by food-frequency questionnaire. Incident depression was measured by the presence of ≥4 depressive symptoms from the 10-item version of the Center for Epidemiologic Studies Depression scale. Results: The logistic regression models, which used generalized estimating equations, showed that higher total intakes, which included supplementation, of vitamins B-6 and B-12 were associated with a decreased likelihood of incident depression for up to 12 y of follow-up, after adjustment for age, sex, race, education, income, and antidepressant medication use. For example, each 10 additional milligrams of vitamin B-6 and 10 additional micrograms of vitamin B-12 were associated with 2{\%} lower odds of depressive symptoms per year. There was no association between depressive symptoms and food intakes of these vitamins or folate. These associations remained after adjustment for smoking, alcohol use, widowhood, caregiving status, cognitive function, physical disability, and medical conditions. Conclusion: Our results support the hypotheses that high total intakes of vitamins B-6 and B-12 are protective of depressive symptoms over time in community-residing older adults.",
author = "Skarupski, {Kimberly A.} and Christine Tangney and Hong Li and Bichun Ouyang and Evans, {Denis A.} and Morris, {Martha Clare}",
year = "2010",
month = "8",
day = "1",
doi = "10.3945/ajcn.2010.29413",
language = "English (US)",
volume = "92",
pages = "330--335",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "2",

}

TY - JOUR

T1 - Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time

AU - Skarupski, Kimberly A.

AU - Tangney, Christine

AU - Li, Hong

AU - Ouyang, Bichun

AU - Evans, Denis A.

AU - Morris, Martha Clare

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Background: B-vitamin deficiencies have been associated with depression; however, there is very little prospective evidence from population-based studies of older adults. Objective: We examined whether dietary intakes of vitamins B-6, folate, or vitamin B-12 were predictive of depressive symptoms over an average of 7.2 y in a community-based population of older adults. Design: The study sample consisted of 3503 adults from the Chicago Health and Aging project, an ongoing, population-based, biracial (59% African American) study in adults aged ≥65 y. Dietary assessment was made by food-frequency questionnaire. Incident depression was measured by the presence of ≥4 depressive symptoms from the 10-item version of the Center for Epidemiologic Studies Depression scale. Results: The logistic regression models, which used generalized estimating equations, showed that higher total intakes, which included supplementation, of vitamins B-6 and B-12 were associated with a decreased likelihood of incident depression for up to 12 y of follow-up, after adjustment for age, sex, race, education, income, and antidepressant medication use. For example, each 10 additional milligrams of vitamin B-6 and 10 additional micrograms of vitamin B-12 were associated with 2% lower odds of depressive symptoms per year. There was no association between depressive symptoms and food intakes of these vitamins or folate. These associations remained after adjustment for smoking, alcohol use, widowhood, caregiving status, cognitive function, physical disability, and medical conditions. Conclusion: Our results support the hypotheses that high total intakes of vitamins B-6 and B-12 are protective of depressive symptoms over time in community-residing older adults.

AB - Background: B-vitamin deficiencies have been associated with depression; however, there is very little prospective evidence from population-based studies of older adults. Objective: We examined whether dietary intakes of vitamins B-6, folate, or vitamin B-12 were predictive of depressive symptoms over an average of 7.2 y in a community-based population of older adults. Design: The study sample consisted of 3503 adults from the Chicago Health and Aging project, an ongoing, population-based, biracial (59% African American) study in adults aged ≥65 y. Dietary assessment was made by food-frequency questionnaire. Incident depression was measured by the presence of ≥4 depressive symptoms from the 10-item version of the Center for Epidemiologic Studies Depression scale. Results: The logistic regression models, which used generalized estimating equations, showed that higher total intakes, which included supplementation, of vitamins B-6 and B-12 were associated with a decreased likelihood of incident depression for up to 12 y of follow-up, after adjustment for age, sex, race, education, income, and antidepressant medication use. For example, each 10 additional milligrams of vitamin B-6 and 10 additional micrograms of vitamin B-12 were associated with 2% lower odds of depressive symptoms per year. There was no association between depressive symptoms and food intakes of these vitamins or folate. These associations remained after adjustment for smoking, alcohol use, widowhood, caregiving status, cognitive function, physical disability, and medical conditions. Conclusion: Our results support the hypotheses that high total intakes of vitamins B-6 and B-12 are protective of depressive symptoms over time in community-residing older adults.

UR - http://www.scopus.com/inward/record.url?scp=77955482603&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955482603&partnerID=8YFLogxK

U2 - 10.3945/ajcn.2010.29413

DO - 10.3945/ajcn.2010.29413

M3 - Article

C2 - 20519557

AN - SCOPUS:77955482603

VL - 92

SP - 330

EP - 335

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 2

ER -