Longitudinal association between medication adherence and lung health in people with cystic fibrosis

Michelle N. Eakin, Andrew Bilderback, Michael P. Boyle, Peter J. Mogayzel, Kristin A. Riekert

Research output: Contribution to journalArticlepeer-review


Background: This study examined the relationship of medication adherence to frequency of pulmonary exacerbation and rate of decline in FEV1% predicted (FEV1). Methods: 95 CF patients aged 6years or older and prescribed a pulmonary medication, were enrolled in a longitudinal retrospective review of medication adherence and health outcomes (the occurrence and frequency of intravenous (IV) antibiotic treatments and FEV1) over 12-months. Pharmacy refill records were used to calculate a medication possession ratio (MPR). Results: Composite MPR predicted the occurrence of at least one pulmonary exacerbation requiring a course of IV antibiotics (IRR=2.34, p=0.05), but not the frequency of exacerbations, after controlling for gender, baseline FEV1, and regimen complexity. Composite MPR predicted baseline FEV1 (estimate=29.81, p=007), but not decline in FEV1. Conclusions: These results demonstrate a significant relation between medication adherence and IV antibiotics in CF patients, highlighting the importance of addressing adherence during clinic visits to improve health outcomes.

Original languageEnglish (US)
Pages (from-to)258-264
Number of pages7
JournalJournal of Cystic Fibrosis
Issue number4
StatePublished - Jul 2011


  • Adherence
  • Cystic fibrosis
  • Health outcomes
  • Pulmonary exacerbation
  • Treatment

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine


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