Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease

Nonalcoholic Steatohepatitis Clinical Research Network

Research output: Contribution to journalArticle

Abstract

Objective: Nonalcoholic fatty liver disease (NAFLD) affects 9.6% of children and may put these children at elevated risk of high blood pressure and subsequent cardiovascular morbidity and mortality. Therefore, we sought to determine the prevalence of and risk factors for high blood pressure in children with NAFLD. Methods: Cohort study performed by the NIDDK NASH Clinical Research Network. There were 484 children with NAFLD ages 2 to 17 at enrollment; 382 children were assessed both at enrollment and 48 weeks afterwards. The main outcomes were high blood pressure at baseline and persistent high blood pressure at both baseline and 48 weeks. Results: Prevalence of high blood pressure at baseline was 35.8% and prevalence of persistent high blood pressure was 21.4%. Children with high blood pressure were significantly more likely to have worse steatosis than children without high blood pressure (mild 19.8% vs. 34.2%, moderate 35.0% vs. 30.7%, severe 45.2% vs. 35.1%; P=0.003). Higher body mass index, low-density lipoprotein, and uric acid were independent risk factors for high blood pressure (Odds Ratios: 1.10 per kg/m2, 1.09 per 10 mg/dL, 1.25 per mg/dL, respectively). Compared to boys, girls with NAFLD were significantly more likely to have persistent high blood pressure (28.4% vs.18.9%; P=0.05). Conclusions: In conclusion, NAFLD is a common clinical problem that places children at substantial risk for high blood pressure, which may often go undiagnosed. Thus blood pressure evaluation, control, and monitoring should be an integral component of the clinical management of children with NAFLD.

Original languageEnglish (US)
Article numbere112569
JournalPLoS One
Volume9
Issue number11
DOIs
StatePublished - Nov 24 2014

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fatty liver
Blood pressure
Liver
hypertension
Hypertension
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Non-alcoholic Fatty Liver Disease
risk factors
uric acid
low density lipoprotein
Uric Acid
cohort studies
LDL Lipoproteins
odds ratio
blood pressure
morbidity
body mass index
Body Mass Index
Cohort Studies
Odds Ratio

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease. / Nonalcoholic Steatohepatitis Clinical Research Network.

In: PLoS One, Vol. 9, No. 11, e112569, 24.11.2014.

Research output: Contribution to journalArticle

Nonalcoholic Steatohepatitis Clinical Research Network. / Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease. In: PLoS One. 2014 ; Vol. 9, No. 11.
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title = "Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease",
abstract = "Objective: Nonalcoholic fatty liver disease (NAFLD) affects 9.6{\%} of children and may put these children at elevated risk of high blood pressure and subsequent cardiovascular morbidity and mortality. Therefore, we sought to determine the prevalence of and risk factors for high blood pressure in children with NAFLD. Methods: Cohort study performed by the NIDDK NASH Clinical Research Network. There were 484 children with NAFLD ages 2 to 17 at enrollment; 382 children were assessed both at enrollment and 48 weeks afterwards. The main outcomes were high blood pressure at baseline and persistent high blood pressure at both baseline and 48 weeks. Results: Prevalence of high blood pressure at baseline was 35.8{\%} and prevalence of persistent high blood pressure was 21.4{\%}. Children with high blood pressure were significantly more likely to have worse steatosis than children without high blood pressure (mild 19.8{\%} vs. 34.2{\%}, moderate 35.0{\%} vs. 30.7{\%}, severe 45.2{\%} vs. 35.1{\%}; P=0.003). Higher body mass index, low-density lipoprotein, and uric acid were independent risk factors for high blood pressure (Odds Ratios: 1.10 per kg/m2, 1.09 per 10 mg/dL, 1.25 per mg/dL, respectively). Compared to boys, girls with NAFLD were significantly more likely to have persistent high blood pressure (28.4{\%} vs.18.9{\%}; P=0.05). Conclusions: In conclusion, NAFLD is a common clinical problem that places children at substantial risk for high blood pressure, which may often go undiagnosed. Thus blood pressure evaluation, control, and monitoring should be an integral component of the clinical management of children with NAFLD.",
author = "{Nonalcoholic Steatohepatitis Clinical Research Network} and Schwimmer, {Jeffrey B.} and Anne Zepeda and Newton, {Kimberly P.} and Xanthakos, {Stavra A.} and Cynthia Behling and Hallinan, {Erin K.} and Michele Donithan and Tonascia, {James A}",
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AU - Xanthakos, Stavra A.

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AB - Objective: Nonalcoholic fatty liver disease (NAFLD) affects 9.6% of children and may put these children at elevated risk of high blood pressure and subsequent cardiovascular morbidity and mortality. Therefore, we sought to determine the prevalence of and risk factors for high blood pressure in children with NAFLD. Methods: Cohort study performed by the NIDDK NASH Clinical Research Network. There were 484 children with NAFLD ages 2 to 17 at enrollment; 382 children were assessed both at enrollment and 48 weeks afterwards. The main outcomes were high blood pressure at baseline and persistent high blood pressure at both baseline and 48 weeks. Results: Prevalence of high blood pressure at baseline was 35.8% and prevalence of persistent high blood pressure was 21.4%. Children with high blood pressure were significantly more likely to have worse steatosis than children without high blood pressure (mild 19.8% vs. 34.2%, moderate 35.0% vs. 30.7%, severe 45.2% vs. 35.1%; P=0.003). Higher body mass index, low-density lipoprotein, and uric acid were independent risk factors for high blood pressure (Odds Ratios: 1.10 per kg/m2, 1.09 per 10 mg/dL, 1.25 per mg/dL, respectively). Compared to boys, girls with NAFLD were significantly more likely to have persistent high blood pressure (28.4% vs.18.9%; P=0.05). Conclusions: In conclusion, NAFLD is a common clinical problem that places children at substantial risk for high blood pressure, which may often go undiagnosed. Thus blood pressure evaluation, control, and monitoring should be an integral component of the clinical management of children with NAFLD.

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