TY - JOUR
T1 - Longitudinal and cross-sectional estimates of pulmonary function decline in never-smoking adults
AU - Ware, James H.
AU - Dockery, Douglas W.
AU - Louis, Thomas A.
AU - Xu, Xiping
AU - Ferris, Benjamin G.
AU - Speizer, Frank E.
N1 - Funding Information:
School of Public Health, Minneapolis, MN. Reprint requests to Dr. Douglas W. Dockery, Department of Environmental Science and Physiology, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115. Supported in part by National Institute of Environmental Health Sciences Grant ES-01108 and ES-0002, Environmental Protection Agency Cooperative Agreement CR-811650 and Electric Power Research Institute Contract RP-1001. Dr. Dockery was supported by a Mellon Foundation Faculty Development Award.
PY - 1990/10
Y1 - 1990/10
N2 - This paper describes methods for simultaneous cross-sectional and longitudinal analysis of repeated measurements obtained in cohort studies with regular examination schedules, then uses these methods to describe age-related changes in pulmonary function level among nonsmoking participants in the Six Cities Study, a longitudinal study of air pollution and respiratory health conducted between 1974 and 1983 in Watertown, Massachusetts; Kingston and Harriman, Tennessee; St. Louis, Missouri; Steubenville, Ohio; Portage, Wisconsin; and Topeka, Kansas. The subjects, initially aged 25-74, were examined on three occasions at 3-year intervals. Individual rates of loss increased more rapidly with age than predicted from the cross-sectional model. For example, for a male of height 1.75 m, the cross-sectional model predicted an increase in the annual rate of loss of FEV1 from 23.7 ml/yr at age 25 to 39.0 ml/yr at age 75, while the longitudinal model gave rates of loss increasing from 12.9 ml/yr at age 25 to 58.2 ml/yr at age 75. These results contrast with those of other studies comparing longitudinal and cross-sectional estimates of pulmonary function loss.
AB - This paper describes methods for simultaneous cross-sectional and longitudinal analysis of repeated measurements obtained in cohort studies with regular examination schedules, then uses these methods to describe age-related changes in pulmonary function level among nonsmoking participants in the Six Cities Study, a longitudinal study of air pollution and respiratory health conducted between 1974 and 1983 in Watertown, Massachusetts; Kingston and Harriman, Tennessee; St. Louis, Missouri; Steubenville, Ohio; Portage, Wisconsin; and Topeka, Kansas. The subjects, initially aged 25-74, were examined on three occasions at 3-year intervals. Individual rates of loss increased more rapidly with age than predicted from the cross-sectional model. For example, for a male of height 1.75 m, the cross-sectional model predicted an increase in the annual rate of loss of FEV1 from 23.7 ml/yr at age 25 to 39.0 ml/yr at age 75, while the longitudinal model gave rates of loss increasing from 12.9 ml/yr at age 25 to 58.2 ml/yr at age 75. These results contrast with those of other studies comparing longitudinal and cross-sectional estimates of pulmonary function loss.
KW - Cross-sectional studies
KW - Longitudinal studies
KW - Lung
KW - Models
KW - Respiratory function tests
KW - Spirometry
KW - Statistical
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U2 - 10.1093/oxfordjournals.aje.a115710
DO - 10.1093/oxfordjournals.aje.a115710
M3 - Article
C2 - 2403109
AN - SCOPUS:0025008154
SN - 0002-9262
VL - 132
SP - 685
EP - 700
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 4
ER -