Longitudinal analysis of the humoral immune response to human immunodeficiency virus type 1 (HIV-1) gp160 epitopes in rapidly progressing and nonprogressing HIV-1-infected subjects

Michael T. Wong, Ronald Q. Warren, Stephanie A. Anderson, Matthew J. Dolan, Craig W. Hendrix, Craig Hendrix, Gregory P. Melcher, R. Neal Boswell, Ronald C. Kennedy

Research output: Contribution to journalArticle

Abstract

Antibody response to conserved human immunodeficiency virus type 1 (HIV-1)IIIB gp160 epitopes was longitudinally examined in HIV-1-infected persons. Twelve hundred individuals were evaluated, and sequential sera from 25 rapidly progressing (RP) and 30 nonprogressing (NP) subjects collected over an average of 4 years were examined. Initial sera from the RP group contained greater reactivity to a gp120 epitope defined by peptide 503-528 than did sera from the NP group (P <.001). Reactivity declined with sequential sera for the RP group, paralleling disease progression. Conversely, antibody recognition to this site developed in 23% of the NP group with time. However, 60% of the NP group never developed a response to this epitope. This suggests sequential examination of antibody response to an epitope within the gp120 carboxyl-terminus may have prognostic significance. No association between antibodies directed against the gp160 epitopes and in vitro neutralizing activity against HIV-1IIIB was observed.

Original languageEnglish (US)
Pages (from-to)1523-1527
Number of pages5
JournalJournal of Infectious Diseases
Volume168
Issue number6
StatePublished - Dec 1993
Externally publishedYes

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Humoral Immunity
HIV-1
Epitopes
Serum
Antibody Formation
Antibodies
Disease Progression
HIV
Peptides

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Longitudinal analysis of the humoral immune response to human immunodeficiency virus type 1 (HIV-1) gp160 epitopes in rapidly progressing and nonprogressing HIV-1-infected subjects. / Wong, Michael T.; Warren, Ronald Q.; Anderson, Stephanie A.; Dolan, Matthew J.; Hendrix, Craig W.; Hendrix, Craig; Melcher, Gregory P.; Boswell, R. Neal; Kennedy, Ronald C.

In: Journal of Infectious Diseases, Vol. 168, No. 6, 12.1993, p. 1523-1527.

Research output: Contribution to journalArticle

Wong, Michael T. ; Warren, Ronald Q. ; Anderson, Stephanie A. ; Dolan, Matthew J. ; Hendrix, Craig W. ; Hendrix, Craig ; Melcher, Gregory P. ; Boswell, R. Neal ; Kennedy, Ronald C. / Longitudinal analysis of the humoral immune response to human immunodeficiency virus type 1 (HIV-1) gp160 epitopes in rapidly progressing and nonprogressing HIV-1-infected subjects. In: Journal of Infectious Diseases. 1993 ; Vol. 168, No. 6. pp. 1523-1527.
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