Longitudinal analysis of behavioral, neurophysiological, viral and immunological effects of SIV infection in rhesus monkeys

Lisa H. Gold, Howard S. Fox, Steven J. Henriksen, Michael J. Buchmeier, Michael R. Weed, Michael A. Taffe, Salvador Huitron-Resendiz, Thomas F.W. Horn, Floyd E. Bloom

Research output: Contribution to journalArticlepeer-review

Abstract

A model is proposed in which a neurovirulent, microglial-passaged, simian immunodeficiency virus (SIV) is used to produce central nervous system (CNS) pathology and behavioral deficits in rhesus monkeys reminiscent of those seen in humans infected with human immunodeficiency virus (HIV). The time course of disease progression was characterized by using functional measures of cognition and motor skill, as well as neurophysiologic monitoring. Concomitant assessment of immunological and virological parameters illustrated correspondence between impaired behavioral performance and viral pathogenesis. Convergent results were obtained from neuropathological findings indicative of significant CNS disease. In ongoing studies, this SIV model is being used to explore the behavioral sequelae of immunodeficiency virus infection, the viral and host factors leading to neurologic dysfunction, and to begin testing potential therapeutic agents.

Original languageEnglish (US)
Pages (from-to)104-112
Number of pages9
JournalJournal of medical primatology
Volume27
Issue number2-3
DOIs
StatePublished - 1998

Keywords

  • AIDS
  • CNS
  • Dementia
  • Immunodeficiency
  • Macaque
  • Neuropsychological

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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