Longevity candidate genes and their association with personality traits in the elderly

Michelle Luciano; Lorna M. Lopez; Marleen H M De Moor; Sarah E. Harris; Gail Davies; Teresa Nutile; Robert F. Krueger; Tõnu Esko; David Schlessinger; Tanaka Toshiko; Jaime L. Derringer; Anu Realo; Narelle K. Hansell; Michele L. Pergadia; Anu Katriina Pesonen; Serena Sanna; Antonio Terracciano; Pamela A F Madden; Brenda Penninx; Philip Spinhoven; Catherina A. Hartman; Ben A. Oostra; A. Cecile J W Janssens; Johan G. Eriksson; John M. Starr; Alessandra Cannas; Luigi Ferrucci; Andres Metspalu; Margeret J. Wright; Andrew C. Heath; Cornelia M. van Duijn; Laura J. Bierut; Katri Raikkonen; Nicholas G. Martin; Marina Ciullo; Dan Rujescu; Dorret I. Boomsma; Ian J. Deary

doi:10.1002/ajmg.b.32013

Longevity candidate genes and their association with personality traits in the elderly

Michelle Luciano, Lorna M. Lopez, Marleen H M De Moor, Sarah E. Harris, Gail Davies, Teresa Nutile, Robert F. Krueger, Tõnu Esko, David Schlessinger, Tanaka Toshiko, Jaime L. Derringer, Anu Realo, Narelle K. Hansell, Michele L. Pergadia, Anu Katriina Pesonen, Serena Sanna, Antonio Terracciano, Pamela A F Madden, Brenda Penninx, Philip SpinhovenCatherina A. Hartman, Ben A. Oostra, A. Cecile J W Janssens, Johan G. Eriksson, John M. Starr, Alessandra Cannas, Luigi Ferrucci, Andres Metspalu, Margeret J. Wright, Andrew C. Heath, Cornelia M. van Duijn, Laura J. Bierut, Katri Raikkonen, Nicholas G. Martin, Marina Ciullo, Dan Rujescu, Dorret I. Boomsma, Ian J. Deary

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Human longevity and personality traits are both heritable and are consistently linked at the phenotypic level. We test the hypothesis that candidate genes influencing longevity in lower organisms are associated with variance in the five major dimensions of human personality (measured by the NEO-FFI and IPIP inventories) plus related mood states of anxiety and depression. Seventy single nucleotide polymorphisms (SNPs) in six brain expressed, longevity candidate genes (AFG3L2, FRAP1, MAT1A, MAT2A, SYNJ1, and SYNJ2) were typed in over 1,000 70-year old participants from the Lothian Birth Cohort of 1936 (LBC1936). No SNPs were associated with the personality and psychological distress traits at a Bonferroni corrected level of significance (P60 years). Because we selected a specific set of longevity genes based on functional genomics findings, further research on other longevity gene candidates is warranted to discover whether they are relevant candidates for personality and psychological distress traits.

Original language	English (US)
Pages (from-to)	192-200
Number of pages	9
Journal	American Journal of Medical Genetics - Neuropsychiatric Genetics
Volume	159 B
Issue number	2
DOIs	https://doi.org/10.1002/ajmg.b.32013
State	Published - Mar 2012
Externally published	Yes

Keywords

Aging
Anxiety
Depressive symptoms
Genetics
IPIP personality
NEO personality

ASJC Scopus subject areas

Genetics(clinical)
Psychiatry and Mental health
Cellular and Molecular Neuroscience

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10.1002/ajmg.b.32013

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Luciano, M., Lopez, L. M., De Moor, M. H. M., Harris, S. E., Davies, G., Nutile, T., Krueger, R. F., Esko, T., Schlessinger, D., Toshiko, T., Derringer, J. L., Realo, A., Hansell, N. K., Pergadia, M. L., Pesonen, A. K., Sanna, S., Terracciano, A., Madden, P. A. F., Penninx, B., ... Deary, I. J. (2012). Longevity candidate genes and their association with personality traits in the elderly. American Journal of Medical Genetics - Neuropsychiatric Genetics, 159 B(2), 192-200. https://doi.org/10.1002/ajmg.b.32013

Luciano, M, Lopez, LM, De Moor, MHM, Harris, SE, Davies, G, Nutile, T, Krueger, RF, Esko, T, Schlessinger, D, Toshiko, T, Derringer, JL, Realo, A, Hansell, NK, Pergadia, ML, Pesonen, AK, Sanna, S, Terracciano, A, Madden, PAF, Penninx, B, Spinhoven, P, Hartman, CA, Oostra, BA, Janssens, ACJW, Eriksson, JG, Starr, JM, Cannas, A, Ferrucci, L, Metspalu, A, Wright, MJ, Heath, AC, van Duijn, CM, Bierut, LJ, Raikkonen, K, Martin, NG, Ciullo, M, Rujescu, D, Boomsma, DI & Deary, IJ 2012, 'Longevity candidate genes and their association with personality traits in the elderly', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 159 B, no. 2, pp. 192-200. https://doi.org/10.1002/ajmg.b.32013

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abstract = "Human longevity and personality traits are both heritable and are consistently linked at the phenotypic level. We test the hypothesis that candidate genes influencing longevity in lower organisms are associated with variance in the five major dimensions of human personality (measured by the NEO-FFI and IPIP inventories) plus related mood states of anxiety and depression. Seventy single nucleotide polymorphisms (SNPs) in six brain expressed, longevity candidate genes (AFG3L2, FRAP1, MAT1A, MAT2A, SYNJ1, and SYNJ2) were typed in over 1,000 70-year old participants from the Lothian Birth Cohort of 1936 (LBC1936). No SNPs were associated with the personality and psychological distress traits at a Bonferroni corrected level of significance (P60 years). Because we selected a specific set of longevity genes based on functional genomics findings, further research on other longevity gene candidates is warranted to discover whether they are relevant candidates for personality and psychological distress traits.",

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author = "Michelle Luciano and Lopez, {Lorna M.} and {De Moor}, {Marleen H M} and Harris, {Sarah E.} and Gail Davies and Teresa Nutile and Krueger, {Robert F.} and T{\~o}nu Esko and David Schlessinger and Tanaka Toshiko and Derringer, {Jaime L.} and Anu Realo and Hansell, {Narelle K.} and Pergadia, {Michele L.} and Pesonen, {Anu Katriina} and Serena Sanna and Antonio Terracciano and Madden, {Pamela A F} and Brenda Penninx and Philip Spinhoven and Hartman, {Catherina A.} and Oostra, {Ben A.} and Janssens, {A. Cecile J W} and Eriksson, {Johan G.} and Starr, {John M.} and Alessandra Cannas and Luigi Ferrucci and Andres Metspalu and Wright, {Margeret J.} and Heath, {Andrew C.} and {van Duijn}, {Cornelia M.} and Bierut, {Laura J.} and Katri Raikkonen and Martin, {Nicholas G.} and Marina Ciullo and Dan Rujescu and Boomsma, {Dorret I.} and Deary, {Ian J.}",

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AU - Luciano, Michelle

AU - Lopez, Lorna M.

AU - De Moor, Marleen H M

AU - Harris, Sarah E.

AU - Davies, Gail

AU - Nutile, Teresa

AU - Krueger, Robert F.

AU - Esko, Tõnu

AU - Schlessinger, David

AU - Toshiko, Tanaka

AU - Derringer, Jaime L.

AU - Realo, Anu

AU - Hansell, Narelle K.

AU - Pergadia, Michele L.

AU - Pesonen, Anu Katriina

AU - Sanna, Serena

AU - Terracciano, Antonio

AU - Madden, Pamela A F

AU - Penninx, Brenda

AU - Spinhoven, Philip

AU - Hartman, Catherina A.

AU - Oostra, Ben A.

AU - Janssens, A. Cecile J W

AU - Eriksson, Johan G.

AU - Starr, John M.

AU - Cannas, Alessandra

AU - Ferrucci, Luigi

AU - Metspalu, Andres

AU - Wright, Margeret J.

AU - Heath, Andrew C.

AU - van Duijn, Cornelia M.

AU - Bierut, Laura J.

AU - Raikkonen, Katri

AU - Martin, Nicholas G.

AU - Ciullo, Marina

AU - Rujescu, Dan

AU - Boomsma, Dorret I.

AU - Deary, Ian J.

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N2 - Human longevity and personality traits are both heritable and are consistently linked at the phenotypic level. We test the hypothesis that candidate genes influencing longevity in lower organisms are associated with variance in the five major dimensions of human personality (measured by the NEO-FFI and IPIP inventories) plus related mood states of anxiety and depression. Seventy single nucleotide polymorphisms (SNPs) in six brain expressed, longevity candidate genes (AFG3L2, FRAP1, MAT1A, MAT2A, SYNJ1, and SYNJ2) were typed in over 1,000 70-year old participants from the Lothian Birth Cohort of 1936 (LBC1936). No SNPs were associated with the personality and psychological distress traits at a Bonferroni corrected level of significance (P60 years). Because we selected a specific set of longevity genes based on functional genomics findings, further research on other longevity gene candidates is warranted to discover whether they are relevant candidates for personality and psychological distress traits.

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KW - Anxiety

KW - Depressive symptoms

KW - Genetics

KW - IPIP personality

KW - NEO personality

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JO - American Journal of Medical Genetics - Neuropsychiatric Genetics

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ER -

Longevity candidate genes and their association with personality traits in the elderly

Abstract

Keywords

ASJC Scopus subject areas

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