Long-term white matter changes after severe traumatic brain injury: A 5-year prospective cohort

J. Dinkel, A. Drier, O. Khalilzadeh, V. Perlbarg, V. Czernecki, R. Gupta, F. Gomas, P. Sanchez, D. Dormont, D. Galanaud, Robert David Stevens, Louis Puybasset

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND PURPOSE: Extensive white matter damage has been documented in patients with severe traumatic brain injury, yet how this damage evolves in the long term is not well understood. We used DTI to study white matter changes at 5 years after traumatic brain injury. MATERIALS AND METHODS: There were 8 healthy control participants and 13 patients with severe traumatic brain injury who were enrolled in a prospective observational study, which included clinical assessment and brainMRimaging in the acute setting (<6 weeks) and 2 years and 5 years after injury. Only subjects with mild to moderate disability or no disability at 1 year were included in this analysis. DTI parameters were measured in 20 different brain regions and were normalized to values obtained in an age-matched control group. RESULTS: In the acute setting, fractional anisotropy was significantly lower in the genu and body of the corpus callosum and in the bilateral corona radiata in patients compared with control participants, whereas radial diffusivity was significantly (P <.05) higher in these tracts. At 2 years, fractional anisotropy in these tracts had further decreased and radial diffusivity had increased. No significant changes were detected between 2 and 5 years after injury. The baseline radial diffusivity and fractional anisotropy values in the anterior aspect of the brain stem, genu and body of the corpus callosum, and the right and left corona radiata were significantly (P <.05) associated with neurocognitive sequelae (including amnesia, aphasia, and dyspraxia) at year 5. CONCLUSIONS: DTI changes in major white matter tracts persist up to 5 years after severe traumatic brain injury and are most pronounced in the corpus callosum and corona radiata. Limited structural change is noted in the interval between 2 and 5 years.

Original languageEnglish (US)
Pages (from-to)23-29
Number of pages7
JournalAmerican Journal of Neuroradiology
Volume35
Issue number1
DOIs
StatePublished - Jan 2014

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Corpus Callosum
Anisotropy
Apraxias
Amnesia
Aphasia
Wounds and Injuries
Brain Stem
Observational Studies
Healthy Volunteers
Research Design
Prospective Studies
Control Groups
Traumatic Brain Injury
White Matter
Brain

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging

Cite this

Dinkel, J., Drier, A., Khalilzadeh, O., Perlbarg, V., Czernecki, V., Gupta, R., ... Puybasset, L. (2014). Long-term white matter changes after severe traumatic brain injury: A 5-year prospective cohort. American Journal of Neuroradiology, 35(1), 23-29. https://doi.org/10.3174/ajnr.A3616

Long-term white matter changes after severe traumatic brain injury : A 5-year prospective cohort. / Dinkel, J.; Drier, A.; Khalilzadeh, O.; Perlbarg, V.; Czernecki, V.; Gupta, R.; Gomas, F.; Sanchez, P.; Dormont, D.; Galanaud, D.; Stevens, Robert David; Puybasset, Louis.

In: American Journal of Neuroradiology, Vol. 35, No. 1, 01.2014, p. 23-29.

Research output: Contribution to journalArticle

Dinkel, J, Drier, A, Khalilzadeh, O, Perlbarg, V, Czernecki, V, Gupta, R, Gomas, F, Sanchez, P, Dormont, D, Galanaud, D, Stevens, RD & Puybasset, L 2014, 'Long-term white matter changes after severe traumatic brain injury: A 5-year prospective cohort', American Journal of Neuroradiology, vol. 35, no. 1, pp. 23-29. https://doi.org/10.3174/ajnr.A3616
Dinkel, J. ; Drier, A. ; Khalilzadeh, O. ; Perlbarg, V. ; Czernecki, V. ; Gupta, R. ; Gomas, F. ; Sanchez, P. ; Dormont, D. ; Galanaud, D. ; Stevens, Robert David ; Puybasset, Louis. / Long-term white matter changes after severe traumatic brain injury : A 5-year prospective cohort. In: American Journal of Neuroradiology. 2014 ; Vol. 35, No. 1. pp. 23-29.
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