Abstract
Objectives: To determine the association between the long-term use of analgesics and progression of osteoarthritis (OA) as evidenced by up to 3-years follow-up worsening of radiographic Kellgren-Lawrence (KL) grade and incidence of knee replacement (KR). Design: Using nearest neighbor matching of the propensity scores with caliper in the Osteoarthritis Initiative (OAI) cohort, 173 index (Analgesic +) and 173 referent (Analgesic -) subjects were included. Analgesic + and - subjects had analgesics in all and none of their visits, respectively. Analgesic + and - subjects were balanced in their demographics, baseline, first, second and third year body mass index (BMI), Western Ontario and McMaster (WOMAC) total score, Physical and Mental health summary scales (SF-12), Physical Activity Scale for the Elderly (PASE) and Charleston Comorbidity Scale. Analgesic + and - subjects were also matched for baseline radiographic KL grade. Interval increase in the KL grade and incidence of KR were defined as the outcome. Results: Included subjects had average 6.5 years of follow-up. By the third year, 44 subjects had an interval increase in the KL grade; 29 in Analgesic + and 15 among Analgesic - subjects (P = 0.024). By the eighth-year, 41 subjects had their first KR; 29 in Analgesic + and 12 among Analgesic - subjects (P = 0.005). Hazard Ratio (HR) of OA progression and KR for Analgesic + subjects was 1.91 (1.02-3.57) and 2.57 (1.31-5.04), respectively. Conclusions: Long-term use of analgesics may be associated with radiographic progression of knee OA and increased risk of future KR.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 597-604 |
| Number of pages | 8 |
| Journal | Osteoarthritis and Cartilage |
| Volume | 24 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2016 |
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Keywords
- Analgesics
- Knee replacement
- Osteoarthritis progression
- Propensity score matching
ASJC Scopus subject areas
- Biomedical Engineering
- Orthopedics and Sports Medicine
- Rheumatology
Cite this
Long term use of analgesics and risk of osteoarthritis progressions and knee replacement : Propensity score matched cohort analysis of data from the Osteoarthritis Initiative. / Hafezi-Nejad, N.; Guermazi, A.; Roemer, F. W.; Eng, John; Zikria, Bashir; Demehri, Shadpour.
In: Osteoarthritis and Cartilage, Vol. 24, No. 4, 01.04.2016, p. 597-604.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long term use of analgesics and risk of osteoarthritis progressions and knee replacement
T2 - Propensity score matched cohort analysis of data from the Osteoarthritis Initiative
AU - Hafezi-Nejad, N.
AU - Guermazi, A.
AU - Roemer, F. W.
AU - Eng, John
AU - Zikria, Bashir
AU - Demehri, Shadpour
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Objectives: To determine the association between the long-term use of analgesics and progression of osteoarthritis (OA) as evidenced by up to 3-years follow-up worsening of radiographic Kellgren-Lawrence (KL) grade and incidence of knee replacement (KR). Design: Using nearest neighbor matching of the propensity scores with caliper in the Osteoarthritis Initiative (OAI) cohort, 173 index (Analgesic +) and 173 referent (Analgesic -) subjects were included. Analgesic + and - subjects had analgesics in all and none of their visits, respectively. Analgesic + and - subjects were balanced in their demographics, baseline, first, second and third year body mass index (BMI), Western Ontario and McMaster (WOMAC) total score, Physical and Mental health summary scales (SF-12), Physical Activity Scale for the Elderly (PASE) and Charleston Comorbidity Scale. Analgesic + and - subjects were also matched for baseline radiographic KL grade. Interval increase in the KL grade and incidence of KR were defined as the outcome. Results: Included subjects had average 6.5 years of follow-up. By the third year, 44 subjects had an interval increase in the KL grade; 29 in Analgesic + and 15 among Analgesic - subjects (P = 0.024). By the eighth-year, 41 subjects had their first KR; 29 in Analgesic + and 12 among Analgesic - subjects (P = 0.005). Hazard Ratio (HR) of OA progression and KR for Analgesic + subjects was 1.91 (1.02-3.57) and 2.57 (1.31-5.04), respectively. Conclusions: Long-term use of analgesics may be associated with radiographic progression of knee OA and increased risk of future KR.
AB - Objectives: To determine the association between the long-term use of analgesics and progression of osteoarthritis (OA) as evidenced by up to 3-years follow-up worsening of radiographic Kellgren-Lawrence (KL) grade and incidence of knee replacement (KR). Design: Using nearest neighbor matching of the propensity scores with caliper in the Osteoarthritis Initiative (OAI) cohort, 173 index (Analgesic +) and 173 referent (Analgesic -) subjects were included. Analgesic + and - subjects had analgesics in all and none of their visits, respectively. Analgesic + and - subjects were balanced in their demographics, baseline, first, second and third year body mass index (BMI), Western Ontario and McMaster (WOMAC) total score, Physical and Mental health summary scales (SF-12), Physical Activity Scale for the Elderly (PASE) and Charleston Comorbidity Scale. Analgesic + and - subjects were also matched for baseline radiographic KL grade. Interval increase in the KL grade and incidence of KR were defined as the outcome. Results: Included subjects had average 6.5 years of follow-up. By the third year, 44 subjects had an interval increase in the KL grade; 29 in Analgesic + and 15 among Analgesic - subjects (P = 0.024). By the eighth-year, 41 subjects had their first KR; 29 in Analgesic + and 12 among Analgesic - subjects (P = 0.005). Hazard Ratio (HR) of OA progression and KR for Analgesic + subjects was 1.91 (1.02-3.57) and 2.57 (1.31-5.04), respectively. Conclusions: Long-term use of analgesics may be associated with radiographic progression of knee OA and increased risk of future KR.
KW - Analgesics
KW - Knee replacement
KW - Osteoarthritis progression
KW - Propensity score matching
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UR - http://www.scopus.com/inward/citedby.url?scp=84960339579&partnerID=8YFLogxK
U2 - 10.1016/j.joca.2015.11.003
DO - 10.1016/j.joca.2015.11.003
M3 - Article
C2 - 26564576
AN - SCOPUS:84960339579
VL - 24
SP - 597
EP - 604
JO - Osteoarthritis and Cartilage
JF - Osteoarthritis and Cartilage
SN - 1063-4584
IS - 4
ER -