Long-term therapy with sorafenib is associated with pancreatic atrophy

Li Xu, Dong Sheng Zhou, Jing Zhao, Gaya Spolverato, Yao Jun Zhang, Sheng Ping Li, Min Shan Chen, Timothy M. Pawlik

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Although the short-term adverse effects of sorafenib are well known, few data exist on long-term toxicity. The objective of the present study was to investigate the prevalence of pancreatic atrophy among a cohort of patients with hepatocellular carcinoma (HCC) who were treated with sorafenib for ≥2 y.

METHODS: Between March 2007 and December 2013, 31 patients with HCC who were treated with sorafenib for ≥2 y were identified. The effect of pancreatic atrophy and enhancement on incidence of adverse events, tumor response, and overall survival (OS) were assessed.

RESULTS: Thirty-one patients with HCC were treated with sorafenib for ≥2 y and met inclusion criteria; 11 patients (35.5%) were Barcelona-clinic liver cancer stage B, whereas 20 patients (64.5%) were Barcelona-clinic liver cancer stage C. Median duration of treatment with sorafenib was 35.2 mo. Pancreatic atrophy and a decrease in pancreatic enhancement occurred in 24 patients (77.4%) and 15 patients (48.4%), respectively. On the basis of the modified response evaluation criteria in solid tumors, four patients (12.9%) had a complete response, 10 patients (32.3%) had a partial response, and 17 patients (54.8%) had stable disease. Patients treated with sorafenib with pancreatic atrophy had a median OS of 49.4 mo (95% confidence interval, 41.2-57.5 mo) compared with 31.2 mo (95% confidence interval, 25.7-36.7 mo) among patients who did not develop pancreatic atrophy (P = 0.009). In contrast, survival was not associated with decreased versus normal enhancement of the pancreas (OS, 47.7 mo versus 41.7 mo, respectively; P = 0.739).

CONCLUSIONS: Pancreatic atrophy occurred in many HCC patients after 2 y of treatment with sorafenib. Patients who experienced pancreatic atrophy had a better tumor response and OS.

Original languageEnglish (US)
Pages (from-to)314-321
Number of pages8
JournalJournal of Surgical Research
Volume199
Issue number2
DOIs
StatePublished - Dec 1 2015

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Keywords

  • Hepatocellular carcinoma
  • Late toxicity
  • Pancreatic atrophy
  • Sorafenib

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Xu, L., Zhou, D. S., Zhao, J., Spolverato, G., Zhang, Y. J., Li, S. P., Chen, M. S., & Pawlik, T. M. (2015). Long-term therapy with sorafenib is associated with pancreatic atrophy. Journal of Surgical Research, 199(2), 314-321. https://doi.org/10.1016/j.jss.2015.04.035