Long term therapy of hereditary angioedema (HAE). Preventive management with fluoxymesterone and oxymetholone in severely affected males and females

Eleven patients with hereditary angioedema (HAE) received long term androgen therapy in a preventive management protocol. Experience of 317 patient months in severely affected males who received fluoxymesterone and 116 patient months in females who received oxymetholone showed a significant reduction in attack rate or severity of attacks of oropharyngeal and peripheral edema and abdominal pain, compared with pretreatment attack rate or attack rate during lapses in therapy. No episodes of laryngeal edema occurred in patients on androgen therapy.