Long-Term Tetracycline Treatment of Chronic Bronchitis

Philip S. Norman, Edward W. Hook, Robert G. Petersdorf, Leighton E. Cluff, Malcolm P. Godfrey, Allan H. Levy

Research output: Contribution to journalArticle

Abstract

Cultures from patients with chronic bronchitis frequently grow hemophilus or pneumococcus. Thirty-two patients with well established chronic bronchitis were treated for 3 months at a time with 1.0 gm. daily of tetracycline, alternated with 3 months of indistinguishable placebos in a double blind study. About onethird as many exacerbations occurred during tetracycline treatment as during placebo treatment. In some patients, daily cough, sputum volume, and dyspnea were somewhat improved during tetracycline treatment. In individual patients there was a good correlation between eradication of pneumococcus and hemophilus and reduction of acute exacerbations. One patient had a fatal acute bronchitis due to an antibioticresistant staphylococcus during tetracycline therapy; otherwise, there was no evidence of replacement of normal flora during tetracycline treatment. Copyright, 1962, by American Medical Association

Original languageEnglish (US)
Pages (from-to)833-840
Number of pages8
JournalJournal of the American Medical Association
Volume179
Issue number11
DOIs
StatePublished - Mar 17 1962

Fingerprint

Chronic Bronchitis
Tetracycline
Haemophilus
Streptococcus pneumoniae
Placebos
Therapeutics
Bronchitis
American Medical Association
Sputum
Staphylococcus
Double-Blind Method
Cough
Dyspnea

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Norman, P. S., Hook, E. W., Petersdorf, R. G., Cluff, L. E., Godfrey, M. P., & Levy, A. H. (1962). Long-Term Tetracycline Treatment of Chronic Bronchitis. Journal of the American Medical Association, 179(11), 833-840. https://doi.org/10.1001/jama.1962.03050110001001

Long-Term Tetracycline Treatment of Chronic Bronchitis. / Norman, Philip S.; Hook, Edward W.; Petersdorf, Robert G.; Cluff, Leighton E.; Godfrey, Malcolm P.; Levy, Allan H.

In: Journal of the American Medical Association, Vol. 179, No. 11, 17.03.1962, p. 833-840.

Research output: Contribution to journalArticle

Norman, PS, Hook, EW, Petersdorf, RG, Cluff, LE, Godfrey, MP & Levy, AH 1962, 'Long-Term Tetracycline Treatment of Chronic Bronchitis', Journal of the American Medical Association, vol. 179, no. 11, pp. 833-840. https://doi.org/10.1001/jama.1962.03050110001001
Norman, Philip S. ; Hook, Edward W. ; Petersdorf, Robert G. ; Cluff, Leighton E. ; Godfrey, Malcolm P. ; Levy, Allan H. / Long-Term Tetracycline Treatment of Chronic Bronchitis. In: Journal of the American Medical Association. 1962 ; Vol. 179, No. 11. pp. 833-840.
@article{c0c9d229ac684e0c8d7544d8caaa777d,
title = "Long-Term Tetracycline Treatment of Chronic Bronchitis",
abstract = "Cultures from patients with chronic bronchitis frequently grow hemophilus or pneumococcus. Thirty-two patients with well established chronic bronchitis were treated for 3 months at a time with 1.0 gm. daily of tetracycline, alternated with 3 months of indistinguishable placebos in a double blind study. About onethird as many exacerbations occurred during tetracycline treatment as during placebo treatment. In some patients, daily cough, sputum volume, and dyspnea were somewhat improved during tetracycline treatment. In individual patients there was a good correlation between eradication of pneumococcus and hemophilus and reduction of acute exacerbations. One patient had a fatal acute bronchitis due to an antibioticresistant staphylococcus during tetracycline therapy; otherwise, there was no evidence of replacement of normal flora during tetracycline treatment. Copyright, 1962, by American Medical Association",
author = "Norman, {Philip S.} and Hook, {Edward W.} and Petersdorf, {Robert G.} and Cluff, {Leighton E.} and Godfrey, {Malcolm P.} and Levy, {Allan H.}",
year = "1962",
month = "3",
day = "17",
doi = "10.1001/jama.1962.03050110001001",
language = "English (US)",
volume = "179",
pages = "833--840",
journal = "JAMA - Journal of the American Medical Association",
issn = "0098-7484",
publisher = "American Medical Association",
number = "11",

}

TY - JOUR

T1 - Long-Term Tetracycline Treatment of Chronic Bronchitis

AU - Norman, Philip S.

AU - Hook, Edward W.

AU - Petersdorf, Robert G.

AU - Cluff, Leighton E.

AU - Godfrey, Malcolm P.

AU - Levy, Allan H.

PY - 1962/3/17

Y1 - 1962/3/17

N2 - Cultures from patients with chronic bronchitis frequently grow hemophilus or pneumococcus. Thirty-two patients with well established chronic bronchitis were treated for 3 months at a time with 1.0 gm. daily of tetracycline, alternated with 3 months of indistinguishable placebos in a double blind study. About onethird as many exacerbations occurred during tetracycline treatment as during placebo treatment. In some patients, daily cough, sputum volume, and dyspnea were somewhat improved during tetracycline treatment. In individual patients there was a good correlation between eradication of pneumococcus and hemophilus and reduction of acute exacerbations. One patient had a fatal acute bronchitis due to an antibioticresistant staphylococcus during tetracycline therapy; otherwise, there was no evidence of replacement of normal flora during tetracycline treatment. Copyright, 1962, by American Medical Association

AB - Cultures from patients with chronic bronchitis frequently grow hemophilus or pneumococcus. Thirty-two patients with well established chronic bronchitis were treated for 3 months at a time with 1.0 gm. daily of tetracycline, alternated with 3 months of indistinguishable placebos in a double blind study. About onethird as many exacerbations occurred during tetracycline treatment as during placebo treatment. In some patients, daily cough, sputum volume, and dyspnea were somewhat improved during tetracycline treatment. In individual patients there was a good correlation between eradication of pneumococcus and hemophilus and reduction of acute exacerbations. One patient had a fatal acute bronchitis due to an antibioticresistant staphylococcus during tetracycline therapy; otherwise, there was no evidence of replacement of normal flora during tetracycline treatment. Copyright, 1962, by American Medical Association

UR - http://www.scopus.com/inward/record.url?scp=73849168642&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=73849168642&partnerID=8YFLogxK

U2 - 10.1001/jama.1962.03050110001001

DO - 10.1001/jama.1962.03050110001001

M3 - Article

VL - 179

SP - 833

EP - 840

JO - JAMA - Journal of the American Medical Association

JF - JAMA - Journal of the American Medical Association

SN - 0098-7484

IS - 11

ER -