Long-term survival of patients with viable and nonviable aneurysms assessed by99mTc-MIBI SPECT and18F-FDG PET: A comparative study of medical and surgical treatment

Xiaoli Zhang, Xiu Jie Liu, Shengshou Hu, Thomas H. Schindler, Yueqing Tian, Zuo Xiang He, Runlin Gao, Qingyu Wu, Hongxing Wei, James W. Sayre, Heinrich R. Schelbert

Research output: Contribution to journalArticlepeer-review

Abstract

The prognostic value of myocardial viability assessment on left ventricular (LV) aneurysms remains undetermined. We aimed, first, to evaluate the long-term survival benefit of assessing the viability of the aneurysmal myocardium in patients with ischemic cardiomyopathy and, second, in the revascularization subgroup, to compare the short-term effects on LV function and clinical symptoms in patients treated by revascularization alone or by revascularization plus aneurysmectomy. Methods: Seventy consecutive patients with an LV aneurysm who underwent 99mTc-sestamibi SPECT and 18F-FDG PET were followed up for a median of 6.8 y (range, 0.1-8.8 y). Only cardiac death during follow-up served as the endpoint. Patients were classified into 4 groups by aneurysmal viability and by treatment strategy (medical or surgical). Further, the effects of aneurysmectomy on LV function at 3 mo were evaluated by an analysis of revascularized patients grouped by aneurysmal viability and by aneurysmectomy. Results: Twenty-four patients were assigned to medical therapy, and 46 patients were assigned to surgery (18 revascularization alone and 28 revascularization plus aneurysmectomy). The annual cardiac mortality rate in patients with a viable aneurysm treated medically (n = 10) was significantly higher than that in patients with a viable aneurysm treated surgically (n = 23) (11.6% vs. 1.5%, χ2 = 12.87, P < 0.0001) and was also significant higher than that in patients with a nonviable aneurysm treated medically (n = 14) (χ2 = 4.13, P < 0.05) or surgically (n = 23) (χ2 = 10.46, P = 0.001). Multivariate analysis showed that the aneurysmal mismatch score (P = 0.003) and surgical therapy (P = 0.001) were independent predictors of cardiac death. Improvement of LV function and symptoms after revascularization (P < 0.05) was observed in patients with revascularization plus aneurysmectomy and in patients with a viable aneurysm and revascularization only. Conclusion: Viability in LV aneurysm in patients with ischemic cardiomyopathy was a negative independent predictor of survival. Compared with medical therapy, coronary revascularization was associated with improved long-term survival, symptoms, and LV function in patients with a viable aneurysm. These findings warrant further prospective investigations.

Original languageEnglish (US)
Pages (from-to)1288-1298
Number of pages11
JournalJournal of Nuclear Medicine
Volume49
Issue number8
DOIs
StatePublished - Aug 1 2008

Keywords

  • Aneurysm
  • Coronary disease
  • Myocardial viability
  • Survival

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Long-term survival of patients with viable and nonviable aneurysms assessed by<sup>99m</sup>Tc-MIBI SPECT and<sup>18</sup>F-FDG PET: A comparative study of medical and surgical treatment'. Together they form a unique fingerprint.

Cite this