Long-term survival of patients with radiation heart disease undergoing cardiac surgery: A cohort study

Willis Wu, Ahmad Masri, Zoran B. Popovic, Nicholas G. Smedira, Bruce W. Lytle, Thomas H. Marwick, Brian P. Griffin, Milind Y. Desai

Research output: Contribution to journalArticle

Abstract

Background-Thoracic radiation results in radiation-associated heart disease (RAHD), often requiring cardiothoracic surgery (CTS). We sought to measure long-term survival in RAHD patients undergoing CTS, to compare them with a matched control population undergoing similar surgical procedures, and to identify potential predictors of long-term survival. Methods and Results-In this retrospective observational cohort study of patients undergoing CTS, matched on the basis of age, sex, and type/time of CTS, 173 RAHD patients (75% women; age, 63±14 years) and 305 comparison patients (74% women; age, 63±4 years) were included. The vast majority of RAHD patients had prior breast cancer (53%) and Hodgkin lymphoma (27%), and the mean time from radiation was 18±12 years. Clinical and surgical parameters were recorded. The preoperative EuroSCORE and all-cause mortality were recorded. The mean EuroSCOREs were similar in the RAHD and comparison groups (7.8±3 versus 7.4±3, respectively; P=0.1). Proximal coronary artery disease was higher in patients with RAHD versus the comparison patients (45% versus 38%; P=0.09), whereas redo CTS was lower in the RACD versus the comparison group (20% versus 29%; P=0.02). About two thirds of patients in either group had combination surgical procedures. During a mean follow-up of 7.6±3 years, a significantly higher proportion of patients died in the RAHD group than in the comparison group (55% versus 28%; P

Original languageEnglish (US)
Pages (from-to)1476-1484
Number of pages9
JournalCirculation
Volume127
Issue number14
DOIs
StatePublished - Apr 9 2013
Externally publishedYes

Fingerprint

Thoracic Surgery
Heart Diseases
Cohort Studies
Radiation
Survival
Background Radiation
Hodgkin Disease
Observational Studies
Coronary Artery Disease
Thorax
Breast Neoplasms
Mortality
Population

Keywords

  • Heart disease
  • Radiation
  • Surgery
  • Survival

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Wu, W., Masri, A., Popovic, Z. B., Smedira, N. G., Lytle, B. W., Marwick, T. H., ... Desai, M. Y. (2013). Long-term survival of patients with radiation heart disease undergoing cardiac surgery: A cohort study. Circulation, 127(14), 1476-1484. https://doi.org/10.1161/CIRCULATIONAHA.113.001435

Long-term survival of patients with radiation heart disease undergoing cardiac surgery : A cohort study. / Wu, Willis; Masri, Ahmad; Popovic, Zoran B.; Smedira, Nicholas G.; Lytle, Bruce W.; Marwick, Thomas H.; Griffin, Brian P.; Desai, Milind Y.

In: Circulation, Vol. 127, No. 14, 09.04.2013, p. 1476-1484.

Research output: Contribution to journalArticle

Wu, W, Masri, A, Popovic, ZB, Smedira, NG, Lytle, BW, Marwick, TH, Griffin, BP & Desai, MY 2013, 'Long-term survival of patients with radiation heart disease undergoing cardiac surgery: A cohort study', Circulation, vol. 127, no. 14, pp. 1476-1484. https://doi.org/10.1161/CIRCULATIONAHA.113.001435
Wu, Willis ; Masri, Ahmad ; Popovic, Zoran B. ; Smedira, Nicholas G. ; Lytle, Bruce W. ; Marwick, Thomas H. ; Griffin, Brian P. ; Desai, Milind Y. / Long-term survival of patients with radiation heart disease undergoing cardiac surgery : A cohort study. In: Circulation. 2013 ; Vol. 127, No. 14. pp. 1476-1484.
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