Long-term survival of a patient with leptomeningeal involvement by nasopharyngeal carcinoma after treatment with high-dose intravenous methotrexate

Carole Fakhry, Gopal Bajaj, Nafi Aygun, William Westra, Maura Gillison

Research output: Contribution to journalArticle


Background. Nasopharyngeal carcinoma with leptomeningeal involvement is rare and typically has poor prognosis. Methods and Results. We present a case report of a patient with nasopharyngeal carcinoma who was treated with high-dose intravenous methotrexate and remains asymptomatic and without clinical evidence of disease 6 years later. Conclusions. Systemic high-dose methotrexate should be evaluated in the treatment of advanced nasopharyngeal carcinoma with central nervous involvement.

Original languageEnglish (US)
Pages (from-to)296-300
Number of pages5
JournalHead and Neck
Issue number2
StatePublished - Feb 2012



  • CNS involvement
  • high-dose methotrexate
  • leptomeningeal disease
  • methotrexate
  • nasopharyngeal carcinoma

ASJC Scopus subject areas

  • Otorhinolaryngology

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