Long-term suppression of adult bladder morbidity and severe hydronephrosis following selective population chemotherapy for Schistosoma haematobium

Aruna K. Subramanian, Peter Mungai, John H. Ouma, Phillip Magak, Charles H. King, Adel A F Mahmoud, Christopher L. King

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Abstract

Repeated selective population chemotherapy of school age children reduces infection and morbidity associated with Schistosoma haematobium infection. To examine the long-term effect of this treatment on susceptibility to re-infection and late disease, a cohort of Kenyans (n = 194) were re-examined for infection and urinary tract morbidity 7-13 years after they underwent annual ultrasonography and treatment for an average of 5 years beginning in 1984 as children. Controls were previously untreated age- matched individuals residing in the same or adjacent villages. The overall prevalence and intensity of infection were equivalent between the 2 groups. In contrast, the prevalence of bladder wall pathology was 11-fold lower in previously treated (1.5%) versus untreated subjects (17%). Severe hydronephrosis was completely reversed. These data demonstrate that treatment significantly reduced urinary tract morbidity despite re-infection, and suggest that the important risk factors for urinary tract morbidity in adulthood are cumulative intensity and duration of infection during early adolescence.

Original languageEnglish (US)
Pages (from-to)476-481
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume61
Issue number3
Publication statusPublished - 1999

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ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Subramanian, A. K., Mungai, P., Ouma, J. H., Magak, P., King, C. H., Mahmoud, A. A. F., & King, C. L. (1999). Long-term suppression of adult bladder morbidity and severe hydronephrosis following selective population chemotherapy for Schistosoma haematobium. American Journal of Tropical Medicine and Hygiene, 61(3), 476-481.