@article{6e05561ead604fe993b154cda0885135,
title = "Long-term renal function in living kidney donors with simple renal cysts: A retrospective cohort study",
abstract = "Simple (Bosniak I) renal cysts are considered acceptable in living kidney donor selection in terms of cancer risk. However, they tend to increase in number and size over time and might compromise renal function in donors. To clarify their implications for long-term renal function, we characterized the prevalence of renal cysts in 454 individuals who donated at our center from 2000 to 2007. We estimated the association between the presence of cysts in the kidney remaining after nephrectomy (ie, retained cysts) and postdonation eGFR trajectory using mixed-effects linear regression. Donors with retained cysts (N = 86) were older (P <.001) and had slightly lower predonation eGFR (median 94 vs 98 mL/min/1.73 m2, P <.01) than those without cysts. Over a median 7.8 years, donors with retained cysts had lower baseline eGFR (−8.7 −5.6 −2.3 mL/min/1.73 m2, P <.01) but similar yearly change in eGFR (−0.4 0.02 0.4 mL/min/1.73 m2, P =.2) compared to those without retained cysts. Adjusting for predonation characteristics, there was no difference in baseline eGFR (P =.6) or yearly change in eGFR (P >.9). There continued to be no evidence of an association when we considered retained cyst(s) ≥10 mm or multiple retained cysts (all P >.05). These findings reaffirm current practices of accepting candidates with simple renal cysts for donor nephrectomy.",
keywords = "donors and donation, glomerular filtration rate, living, renal cyst, renal function",
author = "Waldram, {Madeleine M.} and Thomas, {Alvin G.} and Yifan Yu and Holscher, {Courtenay M.} and Nguyen, {Anh Q.} and Halpern, {Samantha E.} and Shane Ottman and Muzaale, {Abimereki D.} and Henderson, {Macey L.} and Lentine, {Krista L.} and {Al Ammary}, Fawaz and Brennan, {Daniel C.} and Garonzik-Wang, {Jacqueline M.} and Segev, {Dorry L.} and Massie, {Allan B.}",
note = "Funding Information: Funding for this study was provided in part by grants number F32DK109662 (PI: Holscher), K01DK114388 (PI: Henderson), K24DK101828 (PI: Segev), K23DK115908 (PI: Garonzik Wang) R01DK096008 (PI: Segev), and K01DK101677 (PI: Massie) from the National Institute of Diabetes and Digestive and Kidney Disease (NIDDK), by National Heart, Lung, and Blood Institute grant T32HL007055 (support Mr Thomas), and by an American College of Surgeons Resident Research Scholarship (PI: Holscher). The interpretation and reporting of these data are the responsibility of the authors and in no way should be seen as an official policy of or interpretation by the US Government. Funding Information: Funding for this study was provided in part by grants number F32DK109662 (PI: Holscher), K01DK114388 (PI: Henderson), K24DK101828 (PI: Segev), K23DK115908 (PI: Garonzik Wang) R01DK096008 (PI: Segev), and K01DK101677 (PI: Massie) from the National Institute of Diabetes and Digestive and Kidney Disease (NIDDK), by National Heart, Lung, and Blood Institute grant T32HL007055 (support Mr Thomas), and by an American College of Surgeons Resident Research Scholarship (PI: Holscher). The interpretation and reporting of these data are the responsibility of the authors and in no way should be seen as an official policy of or interpretation by the US Government. Publisher Copyright: {\textcopyright} 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",
year = "2020",
month = sep,
day = "1",
doi = "10.1111/ctr.13905",
language = "English (US)",
volume = "34",
journal = "Clinical Transplantation",
issn = "0902-0063",
publisher = "Wiley-Blackwell",
number = "9",
}