TY - JOUR
T1 - Long-term prognosis of patients undergoing electrophysiologic studies for syncope of unknown origin
AU - Bass, Eric B.
AU - Elson, James J.
AU - Fogoros, Richard N.
AU - Peterson, Jacqueline
AU - Arena, Vincent C.
AU - Kapoor, Wishwa N.
N1 - Funding Information:
From the Departments of Medicine and Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania. This study was supported in part by grants from the Richard King Mellon Family Foundation, Pittsburgh, Pennsylvania, and grant 1 ROl HL36735-OlAl from the National Heart, Lung, and Blood Institute, Bethesda, Maryland. Dr. Ka-poor is a recipient of Research Career Development Award lK04L 01899-OlAl from theNational Heart, Lung, and Blood Institute. Manuscript received June 23, 1988; revised manuscript received and accepted August 10, 1988.
PY - 1988/12/1
Y1 - 1988/12/1
N2 - Long-term prognosis was determined in 70 patients with unexplained syncope who underwent electrophysiologic testing between April 1981 and April 1986. The electrophysiologic study had positive results in 37 patients-31 with ventricular tachycardia, 3 with supraventricular tachycardia and 3 with abnormal conduction. There was no significant difference in the 3-year actuarial recurrence rate between the positive and negative outcomes (32 vs 24%, respectively). At 3 years, patients with positive outcomes had higher rates of sudden death than patients with negative results (48 vs 9%, respectively, p < 0.002). The 3-year total mortality rate was also markedly higher in patients with positive results than among those with negative outcomes (61 vs 15%, respectively, p < 0.001). Multivariate analyses showed mortality to be independently associated with unsustained ventricular tachycardia on prolonged electrocardiographic monitoring. It was concluded that patients with electrophysiologically positive results had high rates of sudden death and total mortality that have not been previously well recognized.
AB - Long-term prognosis was determined in 70 patients with unexplained syncope who underwent electrophysiologic testing between April 1981 and April 1986. The electrophysiologic study had positive results in 37 patients-31 with ventricular tachycardia, 3 with supraventricular tachycardia and 3 with abnormal conduction. There was no significant difference in the 3-year actuarial recurrence rate between the positive and negative outcomes (32 vs 24%, respectively). At 3 years, patients with positive outcomes had higher rates of sudden death than patients with negative results (48 vs 9%, respectively, p < 0.002). The 3-year total mortality rate was also markedly higher in patients with positive results than among those with negative outcomes (61 vs 15%, respectively, p < 0.001). Multivariate analyses showed mortality to be independently associated with unsustained ventricular tachycardia on prolonged electrocardiographic monitoring. It was concluded that patients with electrophysiologically positive results had high rates of sudden death and total mortality that have not been previously well recognized.
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U2 - 10.1016/0002-9149(88)90257-3
DO - 10.1016/0002-9149(88)90257-3
M3 - Article
C2 - 3195480
AN - SCOPUS:0023816310
VL - 62
SP - 1186
EP - 1191
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 17
ER -