Long-term prognosis after coronary artery calcification testing in asymptomatic patients: A cohort study

Leslee J. Shaw, Ashley E. Giambrone, Michael Blaha, Joseph T. Knapper, Daniel S. Berman, Naveen Bellam, Arshed Quyyumi, Matthew J. Budoff, Tracy Q. Callister, James K. Min

Research output: Contribution to journalArticle

Abstract

Background: The extent of coronary artery calcification (CAC) and near-term adverse clinical outcomes are strongly related through 5 years of follow-up. Objective: To describe the ability of CAC scores to predict long-term mortality in persons without symptoms of coronary artery disease. Design: Observational cohort. Setting: Single-center, outpatient cardiology laboratory. Patients: 9715 asymptomatic patients. Measurements: Coronary artery calcification scoring and binary risk factor data were collected. The primary end point was time to all-cause mortality (median follow-up, 14.6 years). Univariable and multivariable Cox proportional hazards models were used to compare survival distributions. The net reclassification improvement statistic was calculated. Results: In Cox models adjusted for risk factors for coronary artery disease, the CAC score was highly predictive of all-cause mortality (P <0.001). Overall 15-year mortality rates ranged from 3% to 28% for CAC scores from 0 to 1000 or greater (P <0.001). The relative hazard for all-cause mortality ranged from 1.68 for a CAC score of 1 to 10 (P <0.001) to 6.26 for a score of 1000 or greater (P <0.001). The categorical net reclassification improvement using cut points of less than 7.5% to 22.5% or greater was 0.21 (95% CI, 0.16 to 0.32). Limitations: Data collection was limited to a single center with generalizability limitations. Only binary risk factor data were available, and CAC was only measured once. Conclusion: The extent of CAC accurately predicts 15-year mortality in a large cohort of asymptomatic patients. Long-term estimates of mortality provide a unique opportunity to examine the value of novel biomarkers, such as CAC, in estimating important patient outcomes.

Original languageEnglish (US)
Pages (from-to)14-21
Number of pages8
JournalAnnals of Internal Medicine
Volume163
Issue number1
DOIs
StatePublished - Jul 7 2015

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Coronary Vessels
Cohort Studies
Mortality
Proportional Hazards Models
Coronary Artery Disease
Cardiology
Outpatients
Biomarkers
Survival

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine(all)

Cite this

Shaw, L. J., Giambrone, A. E., Blaha, M., Knapper, J. T., Berman, D. S., Bellam, N., ... Min, J. K. (2015). Long-term prognosis after coronary artery calcification testing in asymptomatic patients: A cohort study. Annals of Internal Medicine, 163(1), 14-21. https://doi.org/10.7326/M14-0612

Long-term prognosis after coronary artery calcification testing in asymptomatic patients : A cohort study. / Shaw, Leslee J.; Giambrone, Ashley E.; Blaha, Michael; Knapper, Joseph T.; Berman, Daniel S.; Bellam, Naveen; Quyyumi, Arshed; Budoff, Matthew J.; Callister, Tracy Q.; Min, James K.

In: Annals of Internal Medicine, Vol. 163, No. 1, 07.07.2015, p. 14-21.

Research output: Contribution to journalArticle

Shaw, LJ, Giambrone, AE, Blaha, M, Knapper, JT, Berman, DS, Bellam, N, Quyyumi, A, Budoff, MJ, Callister, TQ & Min, JK 2015, 'Long-term prognosis after coronary artery calcification testing in asymptomatic patients: A cohort study', Annals of Internal Medicine, vol. 163, no. 1, pp. 14-21. https://doi.org/10.7326/M14-0612
Shaw, Leslee J. ; Giambrone, Ashley E. ; Blaha, Michael ; Knapper, Joseph T. ; Berman, Daniel S. ; Bellam, Naveen ; Quyyumi, Arshed ; Budoff, Matthew J. ; Callister, Tracy Q. ; Min, James K. / Long-term prognosis after coronary artery calcification testing in asymptomatic patients : A cohort study. In: Annals of Internal Medicine. 2015 ; Vol. 163, No. 1. pp. 14-21.
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abstract = "Background: The extent of coronary artery calcification (CAC) and near-term adverse clinical outcomes are strongly related through 5 years of follow-up. Objective: To describe the ability of CAC scores to predict long-term mortality in persons without symptoms of coronary artery disease. Design: Observational cohort. Setting: Single-center, outpatient cardiology laboratory. Patients: 9715 asymptomatic patients. Measurements: Coronary artery calcification scoring and binary risk factor data were collected. The primary end point was time to all-cause mortality (median follow-up, 14.6 years). Univariable and multivariable Cox proportional hazards models were used to compare survival distributions. The net reclassification improvement statistic was calculated. Results: In Cox models adjusted for risk factors for coronary artery disease, the CAC score was highly predictive of all-cause mortality (P <0.001). Overall 15-year mortality rates ranged from 3{\%} to 28{\%} for CAC scores from 0 to 1000 or greater (P <0.001). The relative hazard for all-cause mortality ranged from 1.68 for a CAC score of 1 to 10 (P <0.001) to 6.26 for a score of 1000 or greater (P <0.001). The categorical net reclassification improvement using cut points of less than 7.5{\%} to 22.5{\%} or greater was 0.21 (95{\%} CI, 0.16 to 0.32). Limitations: Data collection was limited to a single center with generalizability limitations. Only binary risk factor data were available, and CAC was only measured once. Conclusion: The extent of CAC accurately predicts 15-year mortality in a large cohort of asymptomatic patients. Long-term estimates of mortality provide a unique opportunity to examine the value of novel biomarkers, such as CAC, in estimating important patient outcomes.",
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AU - Shaw, Leslee J.

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AU - Blaha, Michael

AU - Knapper, Joseph T.

AU - Berman, Daniel S.

AU - Bellam, Naveen

AU - Quyyumi, Arshed

AU - Budoff, Matthew J.

AU - Callister, Tracy Q.

AU - Min, James K.

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N2 - Background: The extent of coronary artery calcification (CAC) and near-term adverse clinical outcomes are strongly related through 5 years of follow-up. Objective: To describe the ability of CAC scores to predict long-term mortality in persons without symptoms of coronary artery disease. Design: Observational cohort. Setting: Single-center, outpatient cardiology laboratory. Patients: 9715 asymptomatic patients. Measurements: Coronary artery calcification scoring and binary risk factor data were collected. The primary end point was time to all-cause mortality (median follow-up, 14.6 years). Univariable and multivariable Cox proportional hazards models were used to compare survival distributions. The net reclassification improvement statistic was calculated. Results: In Cox models adjusted for risk factors for coronary artery disease, the CAC score was highly predictive of all-cause mortality (P <0.001). Overall 15-year mortality rates ranged from 3% to 28% for CAC scores from 0 to 1000 or greater (P <0.001). The relative hazard for all-cause mortality ranged from 1.68 for a CAC score of 1 to 10 (P <0.001) to 6.26 for a score of 1000 or greater (P <0.001). The categorical net reclassification improvement using cut points of less than 7.5% to 22.5% or greater was 0.21 (95% CI, 0.16 to 0.32). Limitations: Data collection was limited to a single center with generalizability limitations. Only binary risk factor data were available, and CAC was only measured once. Conclusion: The extent of CAC accurately predicts 15-year mortality in a large cohort of asymptomatic patients. Long-term estimates of mortality provide a unique opportunity to examine the value of novel biomarkers, such as CAC, in estimating important patient outcomes.

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