Long-term preservation of vision in progressive outer retinal necrosis treated with combination antiviral drugs and highly active antiretroviral therapy

Stephen J. Kim, Robert Equi, Marie Lyne Belair, Howard F. Fine, James P. Dunn

Research output: Contribution to journalArticle

Abstract

Purpose: To report the successful long-term treatment of varicella zoster virus-associated progressive outer retinal necrosis (VZV-PORN) with aggressive antiviral combination drugs along with highly active antiretroviral therapy (HAART). Design: Interventional case report. Methods: Combined treatment of progressive outer retinal necrosis in a university-based tertiary eye hospital with ganciclovir implant, intravenous acyclovir (10 mg/kg every 8 h), intravitreal foscarnet (2.4 mg), and HAART. Results: Successful treatment of progressive outer retinal necrosis with disease remission and preservation of 20/20 visual acuity out to 1 year. Conclusions: Combination antiviral therapy and HAART may improve long-term visual outcomes for VZV-PORN.

Original languageEnglish (US)
Pages (from-to)425-427
Number of pages3
JournalOcular Immunology and Inflammation
Volume15
Issue number6
DOIs
StatePublished - Nov 1 2007

Keywords

  • Ganciclovir implant
  • HIV
  • PORN
  • Progressive outer retinal necrosis
  • Varicella-zoster

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

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