Long-term preservation of vision in progressive outer retinal necrosis treated with combination antiviral drugs and highly active antiretroviral therapy

Stephen J. Kim; Robert Equi; Marie Lyne Belair; Howard F. Fine; James P. Dunn

doi:10.1080/09273940701732255

Long-term preservation of vision in progressive outer retinal necrosis treated with combination antiviral drugs and highly active antiretroviral therapy

Stephen J. Kim, Robert Equi, Marie Lyne Belair, Howard F. Fine, James P. Dunn

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Purpose: To report the successful long-term treatment of varicella zoster virus-associated progressive outer retinal necrosis (VZV-PORN) with aggressive antiviral combination drugs along with highly active antiretroviral therapy (HAART). Design: Interventional case report. Methods: Combined treatment of progressive outer retinal necrosis in a university-based tertiary eye hospital with ganciclovir implant, intravenous acyclovir (10 mg/kg every 8 h), intravitreal foscarnet (2.4 mg), and HAART. Results: Successful treatment of progressive outer retinal necrosis with disease remission and preservation of 20/20 visual acuity out to 1 year. Conclusions: Combination antiviral therapy and HAART may improve long-term visual outcomes for VZV-PORN.

Original language	English (US)
Pages (from-to)	425-427
Number of pages	3
Journal	Ocular Immunology and Inflammation
Volume	15
Issue number	6
DOIs	https://doi.org/10.1080/09273940701732255
State	Published - Nov 2007
Externally published	Yes

Keywords

Ganciclovir implant
HIV
PORN
Progressive outer retinal necrosis
Varicella-zoster

ASJC Scopus subject areas

Immunology and Allergy
Ophthalmology

Access to Document

10.1080/09273940701732255

Cite this

@article{3b4dbe606fed41ca8ce8a09f13fc42d9,

title = "Long-term preservation of vision in progressive outer retinal necrosis treated with combination antiviral drugs and highly active antiretroviral therapy",

abstract = "Purpose: To report the successful long-term treatment of varicella zoster virus-associated progressive outer retinal necrosis (VZV-PORN) with aggressive antiviral combination drugs along with highly active antiretroviral therapy (HAART). Design: Interventional case report. Methods: Combined treatment of progressive outer retinal necrosis in a university-based tertiary eye hospital with ganciclovir implant, intravenous acyclovir (10 mg/kg every 8 h), intravitreal foscarnet (2.4 mg), and HAART. Results: Successful treatment of progressive outer retinal necrosis with disease remission and preservation of 20/20 visual acuity out to 1 year. Conclusions: Combination antiviral therapy and HAART may improve long-term visual outcomes for VZV-PORN.",

keywords = "Ganciclovir implant, HIV, PORN, Progressive outer retinal necrosis, Varicella-zoster",

author = "Kim, {Stephen J.} and Robert Equi and Belair, {Marie Lyne} and Fine, {Howard F.} and Dunn, {James P.}",

year = "2007",

month = nov,

doi = "10.1080/09273940701732255",

language = "English (US)",

volume = "15",

pages = "425--427",

journal = "Ocular Immunology and Inflammation",

issn = "0927-3948",

publisher = "Informa Healthcare",

number = "6",

}

TY - JOUR

T1 - Long-term preservation of vision in progressive outer retinal necrosis treated with combination antiviral drugs and highly active antiretroviral therapy

AU - Kim, Stephen J.

AU - Equi, Robert

AU - Belair, Marie Lyne

AU - Fine, Howard F.

AU - Dunn, James P.

PY - 2007/11

Y1 - 2007/11

N2 - Purpose: To report the successful long-term treatment of varicella zoster virus-associated progressive outer retinal necrosis (VZV-PORN) with aggressive antiviral combination drugs along with highly active antiretroviral therapy (HAART). Design: Interventional case report. Methods: Combined treatment of progressive outer retinal necrosis in a university-based tertiary eye hospital with ganciclovir implant, intravenous acyclovir (10 mg/kg every 8 h), intravitreal foscarnet (2.4 mg), and HAART. Results: Successful treatment of progressive outer retinal necrosis with disease remission and preservation of 20/20 visual acuity out to 1 year. Conclusions: Combination antiviral therapy and HAART may improve long-term visual outcomes for VZV-PORN.

AB - Purpose: To report the successful long-term treatment of varicella zoster virus-associated progressive outer retinal necrosis (VZV-PORN) with aggressive antiviral combination drugs along with highly active antiretroviral therapy (HAART). Design: Interventional case report. Methods: Combined treatment of progressive outer retinal necrosis in a university-based tertiary eye hospital with ganciclovir implant, intravenous acyclovir (10 mg/kg every 8 h), intravitreal foscarnet (2.4 mg), and HAART. Results: Successful treatment of progressive outer retinal necrosis with disease remission and preservation of 20/20 visual acuity out to 1 year. Conclusions: Combination antiviral therapy and HAART may improve long-term visual outcomes for VZV-PORN.

KW - Ganciclovir implant

KW - HIV

KW - PORN

KW - Progressive outer retinal necrosis

KW - Varicella-zoster

UR - http://www.scopus.com/inward/record.url?scp=37349130523&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37349130523&partnerID=8YFLogxK

U2 - 10.1080/09273940701732255

DO - 10.1080/09273940701732255

M3 - Article

C2 - 18085485

AN - SCOPUS:37349130523

SN - 0927-3948

VL - 15

SP - 425

EP - 427

JO - Ocular Immunology and Inflammation

JF - Ocular Immunology and Inflammation

IS - 6

ER -

Long-term preservation of vision in progressive outer retinal necrosis treated with combination antiviral drugs and highly active antiretroviral therapy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this