TY - JOUR
T1 - Long-Term Outcomes of Living Donor Versus Deceased Donor Liver Transplant for Hepatocellular Carcinoma in the United States
AU - Muhammad, Haris
AU - Gurakar, Merve
AU - Ting, Peng Sheng
AU - Alsughayer, Anas M.
AU - Luu, Harry
AU - Zaffar, Duha
AU - Alqahtani, Saleh
AU - Bonder, Alan
AU - Gurakar, Ahmet
AU - Saberi, Behnam
N1 - Funding Information:
From the 1Division of Gastroenterology and Hepatology, the 2Department of Medicine, Osler Residency Program, Johns Hopkins University School of Medicine, Baltimore, Maryland; and the 3Beth Israel Deaconess Medical Center, Harvard Medical School, Division of Gastroenterology and Hepatology, Boston, Massachusetts, USA Acknowledgements: This work was supported in part by Health Resources and Services Administration contract HHSH250-2019-00001C. The authors have no declarations of potential conflicts of interest. Corresponding author: Ahmet Gurakar, Liver Transplant, Section of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Research Building, Suite 918, Baltimore, MD 21205, USA Phone: +1 410 614 3369 E-mail: aguraka1@jhmi.edu
Funding Information:
Figure 1. Trend in the Total Number of Living Donor Liver Transplants in the United States Between 1998 and October 2021 Based on Organ Procurement and Transplantation Network data as of October 14, 2021. This work was supported in part by Health Resources and Services Administration contract. The content is the responsibility of the authors alone and does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.
Publisher Copyright:
© Başkent University 2022.
PY - 2022/3
Y1 - 2022/3
N2 - Objectives: Although living donor liver transplant has become a vital treatment option in hepatocellular carcinoma, controversy remains on whether recurrence and survival rates are different versus deceased donor recipients. Here, we compared clinical characteristics and outcomes between recipients of living and deceased donor liver transplants for hepatocellular carcinoma in the United States. Materials and Methods: Our comparisons used data from the United Network of Organ Sharing/Organ Procurement and Transplantation Network. Results: There were 385 living donor and 25 274 deceased donor liver transplant recipients with diagnosis of hepatocellular carcinoma. Transplant list wait times of ≥6 months were more common in deceased donor (55.9%) versus living donor recipients (45.2%; P < .001). Both recipient groups were comparable with regard to alpha-fetoprotein level <200 ng/mL (P = .18). Only a small percentage in both groups had ≥3 total tumors (P = .73); both groups had similar low transplants outside of Milan criteria (P = .45). Overall, 1-, 5-, and 10-year overall survival rates for deceased versus living donor recipients were similar (91.2% vs 92%, 74% vs 76.4%, 58.9% vs 56.5%; P = .69). On multivariate analysis, Black/African American race/ethnicity was associated with worse outcomes than White race/ethnicity as reference (P < .001), whereas Hispanic and Asian race/ethnicity were more protected. Hepatitis C virus as liver disease etiology was associated with worse outcomes than other etiologies. Tumor characteristics, ≥3 lesions, tumor size, and higher alpha-fetoprotein levels were associated with worse outcomes. Living donor transplant was not associated with higher hazard of death. Among living donor recipients only, largest tumor size was associated with higher risk of death (P = .005). Conclusions: Survival was similar in between the living donor versus deceased donor recipients with hepatocellular carcinoma. With changes in Model for End-Stage Liver Disease exception policies for hepatocellular carcinoma in the United States, living donor transplant for hepatocellular carcinoma could expand the donor pool.
AB - Objectives: Although living donor liver transplant has become a vital treatment option in hepatocellular carcinoma, controversy remains on whether recurrence and survival rates are different versus deceased donor recipients. Here, we compared clinical characteristics and outcomes between recipients of living and deceased donor liver transplants for hepatocellular carcinoma in the United States. Materials and Methods: Our comparisons used data from the United Network of Organ Sharing/Organ Procurement and Transplantation Network. Results: There were 385 living donor and 25 274 deceased donor liver transplant recipients with diagnosis of hepatocellular carcinoma. Transplant list wait times of ≥6 months were more common in deceased donor (55.9%) versus living donor recipients (45.2%; P < .001). Both recipient groups were comparable with regard to alpha-fetoprotein level <200 ng/mL (P = .18). Only a small percentage in both groups had ≥3 total tumors (P = .73); both groups had similar low transplants outside of Milan criteria (P = .45). Overall, 1-, 5-, and 10-year overall survival rates for deceased versus living donor recipients were similar (91.2% vs 92%, 74% vs 76.4%, 58.9% vs 56.5%; P = .69). On multivariate analysis, Black/African American race/ethnicity was associated with worse outcomes than White race/ethnicity as reference (P < .001), whereas Hispanic and Asian race/ethnicity were more protected. Hepatitis C virus as liver disease etiology was associated with worse outcomes than other etiologies. Tumor characteristics, ≥3 lesions, tumor size, and higher alpha-fetoprotein levels were associated with worse outcomes. Living donor transplant was not associated with higher hazard of death. Among living donor recipients only, largest tumor size was associated with higher risk of death (P = .005). Conclusions: Survival was similar in between the living donor versus deceased donor recipients with hepatocellular carcinoma. With changes in Model for End-Stage Liver Disease exception policies for hepatocellular carcinoma in the United States, living donor transplant for hepatocellular carcinoma could expand the donor pool.
KW - Hepatitis C virus
KW - Model for End-Stage Liver Disease
KW - Multivariate analysis
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U2 - 10.6002/ect.2021.0479
DO - 10.6002/ect.2021.0479
M3 - Article
C2 - 35352634
AN - SCOPUS:85127258554
SN - 1304-0855
VL - 20
SP - 279
EP - 284
JO - Experimental and Clinical Transplantation
JF - Experimental and Clinical Transplantation
IS - 3
ER -