TY - JOUR
T1 - Long-term outcomes of endoscopic treatment for colorectal laterally spreading tumor
T2 - a large-scale multicenter retrospective study from China
AU - Li, Yue
AU - Zhang, Yue
AU - Chen, Yao
AU - Wang, Yusi
AU - Dou, Lizhou
AU - Wang, Xianfei
AU - Zhan, Qiang
AU - Zhang, Guoqiang
AU - Qin, Mengbin
AU - Lea, Fayad
AU - Huang, Jiean
AU - Zhang, Qiang
AU - Zhi, Fachao
AU - Peng, Guiyong
AU - Wang, Guiqi
AU - Kumbhari, Vivek
AU - Liu, Side
N1 - Funding Information:
We want to express our gratitude to the Science and Technology Planning Project of Guangdong Province (2017A020215139). Guangdong gastrointestinal disease research center (No. 2017B020209003).
Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021/2
Y1 - 2021/2
N2 - Background: Laterally spreading tumor (LST) is a type of precancerous lesion of colorectal cancer with high malignant potential. The present study aimed to evaluate long-term outcomes of endoscopic treatment for LST in Chinese patients. Methods: This study was a retrospective review of data collected from 653 included patients with LST from six regional representative hospitals in China between January 2007 and January 2017. Demographic characteristics, endoscopic features of LST, operation-related data, and follow-up results were collected and analyzed. Results: LST-granular type (LST-G, 80.3%) was much more common than LST-non-grandular type (LST-NG, 19.7%). The overall submucosal invasion rate of all LSTs was 6.1% and the submucosal invasion rate of LST-NG was significantly higher than that of LST-G (6.79% vs. 3.87%, p = 0.000). The en bloc resection rate of ESD and EMR treatment was 96% and 93.7%, respectively, with pathologic R0 resection rate of 90.1% and 82.8%. After an average duration of follow-up about 34.52 ± 11.76 months, the recurrence rate of ESD was 3.47%, and the recurrence rate of EMR was 8.8% after an average follow-up of about 38.44 ± 4.42 months. However, the recurrence rate of ESD was much lower than piecemeal EMR for LST (3.47% vs. 8.62%, p = 0.017). Retroflexion-assisted technique applied for resection of rectal LST was associated with a significantly shortened operating time (85.40 min vs. 174.18 min, p = 0.002). Conclusion: Endoscopic resection is a safe and efficient modality for the treatment of colorectal LST with a relatively low recurrence rate and shortened operating time with the use of retroflexion.
AB - Background: Laterally spreading tumor (LST) is a type of precancerous lesion of colorectal cancer with high malignant potential. The present study aimed to evaluate long-term outcomes of endoscopic treatment for LST in Chinese patients. Methods: This study was a retrospective review of data collected from 653 included patients with LST from six regional representative hospitals in China between January 2007 and January 2017. Demographic characteristics, endoscopic features of LST, operation-related data, and follow-up results were collected and analyzed. Results: LST-granular type (LST-G, 80.3%) was much more common than LST-non-grandular type (LST-NG, 19.7%). The overall submucosal invasion rate of all LSTs was 6.1% and the submucosal invasion rate of LST-NG was significantly higher than that of LST-G (6.79% vs. 3.87%, p = 0.000). The en bloc resection rate of ESD and EMR treatment was 96% and 93.7%, respectively, with pathologic R0 resection rate of 90.1% and 82.8%. After an average duration of follow-up about 34.52 ± 11.76 months, the recurrence rate of ESD was 3.47%, and the recurrence rate of EMR was 8.8% after an average follow-up of about 38.44 ± 4.42 months. However, the recurrence rate of ESD was much lower than piecemeal EMR for LST (3.47% vs. 8.62%, p = 0.017). Retroflexion-assisted technique applied for resection of rectal LST was associated with a significantly shortened operating time (85.40 min vs. 174.18 min, p = 0.002). Conclusion: Endoscopic resection is a safe and efficient modality for the treatment of colorectal LST with a relatively low recurrence rate and shortened operating time with the use of retroflexion.
KW - Endoscopic treatment
KW - Laterally spreading tumor (LST)
KW - Long-term outcomes
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U2 - 10.1007/s00464-020-07440-8
DO - 10.1007/s00464-020-07440-8
M3 - Article
C2 - 32076862
AN - SCOPUS:85079629529
SN - 0930-2794
VL - 35
SP - 736
EP - 744
JO - Surgical endoscopy
JF - Surgical endoscopy
IS - 2
ER -