Long-Term outcomes after liver transplantation among human immunodeficiency virus-infected recipients

Jayme E. Locke, Christine Durand, Rhiannon D. Reed, Paul A. MacLennan, Shikha Mehta, Allan B Massie, Anoma Nellore, Derek DuBay, Dorry Segev

Research output: Contribution to journalArticle

Abstract

Background. Early outcomes after human immunodeficiency virus (HIV) + liver transplantation (LT) are encouraging, but data are lacking regarding long-Term outcomes and comparisons with matched HIV? patients. Methods. We examined outcomes among 180 HIV+ LT, and compared outcomes to matched HIV? counterfactuals (Scientific Registry of Transplant Recipients 2002-2011). Iterative expanding radius matching (1:10) on recipient age, race, body mass index, hepatitis C virus (HCV), model for end-stage liver disease score, and acute rejection; and donor age and race, cold ischemia time, and year of transplant. Patient survival and graft survival were estimated using Kaplan-Meier methodology and compared using log-rank and Cox proportional hazards. Subgroup analyses were performed by transplant era (early: 2002-2007 vs modern: 2008-2011) and HCV infection status. Results. Compared to matched HIV? controls, HIV+ LT recipients had a 1.68-fold increased risk for death (adjusted hazard ratio [aHR], 1.68, 95% confidence interval [95% CI], 1.28-2.20; P

Original languageEnglish (US)
Pages (from-to)141-146
Number of pages6
JournalTransplantation
Volume100
Issue number1
DOIs
StatePublished - 2016

Fingerprint

Liver Transplantation
HIV
Hepacivirus
Transplants
Cold Ischemia
End Stage Liver Disease
Graft Survival
Virus Diseases
Registries
Body Mass Index
Tissue Donors
Confidence Intervals
Survival

ASJC Scopus subject areas

  • Transplantation

Cite this

Long-Term outcomes after liver transplantation among human immunodeficiency virus-infected recipients. / Locke, Jayme E.; Durand, Christine; Reed, Rhiannon D.; MacLennan, Paul A.; Mehta, Shikha; Massie, Allan B; Nellore, Anoma; DuBay, Derek; Segev, Dorry.

In: Transplantation, Vol. 100, No. 1, 2016, p. 141-146.

Research output: Contribution to journalArticle

Locke, Jayme E. ; Durand, Christine ; Reed, Rhiannon D. ; MacLennan, Paul A. ; Mehta, Shikha ; Massie, Allan B ; Nellore, Anoma ; DuBay, Derek ; Segev, Dorry. / Long-Term outcomes after liver transplantation among human immunodeficiency virus-infected recipients. In: Transplantation. 2016 ; Vol. 100, No. 1. pp. 141-146.
@article{597fc2e82169446fa25ed11b044f1580,
title = "Long-Term outcomes after liver transplantation among human immunodeficiency virus-infected recipients",
abstract = "Background. Early outcomes after human immunodeficiency virus (HIV) + liver transplantation (LT) are encouraging, but data are lacking regarding long-Term outcomes and comparisons with matched HIV? patients. Methods. We examined outcomes among 180 HIV+ LT, and compared outcomes to matched HIV? counterfactuals (Scientific Registry of Transplant Recipients 2002-2011). Iterative expanding radius matching (1:10) on recipient age, race, body mass index, hepatitis C virus (HCV), model for end-stage liver disease score, and acute rejection; and donor age and race, cold ischemia time, and year of transplant. Patient survival and graft survival were estimated using Kaplan-Meier methodology and compared using log-rank and Cox proportional hazards. Subgroup analyses were performed by transplant era (early: 2002-2007 vs modern: 2008-2011) and HCV infection status. Results. Compared to matched HIV? controls, HIV+ LT recipients had a 1.68-fold increased risk for death (adjusted hazard ratio [aHR], 1.68, 95{\%} confidence interval [95{\%} CI], 1.28-2.20; P",
author = "Locke, {Jayme E.} and Christine Durand and Reed, {Rhiannon D.} and MacLennan, {Paul A.} and Shikha Mehta and Massie, {Allan B} and Anoma Nellore and Derek DuBay and Dorry Segev",
year = "2016",
doi = "10.1097/TP.0000000000000829",
language = "English (US)",
volume = "100",
pages = "141--146",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Long-Term outcomes after liver transplantation among human immunodeficiency virus-infected recipients

AU - Locke, Jayme E.

AU - Durand, Christine

AU - Reed, Rhiannon D.

AU - MacLennan, Paul A.

AU - Mehta, Shikha

AU - Massie, Allan B

AU - Nellore, Anoma

AU - DuBay, Derek

AU - Segev, Dorry

PY - 2016

Y1 - 2016

N2 - Background. Early outcomes after human immunodeficiency virus (HIV) + liver transplantation (LT) are encouraging, but data are lacking regarding long-Term outcomes and comparisons with matched HIV? patients. Methods. We examined outcomes among 180 HIV+ LT, and compared outcomes to matched HIV? counterfactuals (Scientific Registry of Transplant Recipients 2002-2011). Iterative expanding radius matching (1:10) on recipient age, race, body mass index, hepatitis C virus (HCV), model for end-stage liver disease score, and acute rejection; and donor age and race, cold ischemia time, and year of transplant. Patient survival and graft survival were estimated using Kaplan-Meier methodology and compared using log-rank and Cox proportional hazards. Subgroup analyses were performed by transplant era (early: 2002-2007 vs modern: 2008-2011) and HCV infection status. Results. Compared to matched HIV? controls, HIV+ LT recipients had a 1.68-fold increased risk for death (adjusted hazard ratio [aHR], 1.68, 95% confidence interval [95% CI], 1.28-2.20; P

AB - Background. Early outcomes after human immunodeficiency virus (HIV) + liver transplantation (LT) are encouraging, but data are lacking regarding long-Term outcomes and comparisons with matched HIV? patients. Methods. We examined outcomes among 180 HIV+ LT, and compared outcomes to matched HIV? counterfactuals (Scientific Registry of Transplant Recipients 2002-2011). Iterative expanding radius matching (1:10) on recipient age, race, body mass index, hepatitis C virus (HCV), model for end-stage liver disease score, and acute rejection; and donor age and race, cold ischemia time, and year of transplant. Patient survival and graft survival were estimated using Kaplan-Meier methodology and compared using log-rank and Cox proportional hazards. Subgroup analyses were performed by transplant era (early: 2002-2007 vs modern: 2008-2011) and HCV infection status. Results. Compared to matched HIV? controls, HIV+ LT recipients had a 1.68-fold increased risk for death (adjusted hazard ratio [aHR], 1.68, 95% confidence interval [95% CI], 1.28-2.20; P

UR - http://www.scopus.com/inward/record.url?scp=84952334357&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84952334357&partnerID=8YFLogxK

U2 - 10.1097/TP.0000000000000829

DO - 10.1097/TP.0000000000000829

M3 - Article

VL - 100

SP - 141

EP - 146

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 1

ER -