Long-Term Oncologic Outcome after Laparoscopic Radical Nephroureterectomy for Upper Tract Transitional Cell Carcinoma

Michael Muntener, Matthew E. Nielsen, Frederico R. Romero, Edward M. Schaeffer, Mohamad E Allaf, Fabio Augusto R Brito, Christian Pavlovich, Louis R. Kavoussi, Thomas W. Jarrett

Research output: Contribution to journalArticle

Abstract

Objective: To assess the long-term oncologic efficacy of laparoscopic radical nephroureterectomy (RNU). Methods: Between August 1993 and May 2001, 39 patients underwent laparoscopic RNU for upper tract transitional cell carcinoma (TCC) at our institution. The medical records of these patients were retrospectively reviewed. Results: Clinical outcomes were available in all 39 patients with an actual follow-up ranging from 60 to 148 mo (median: 74). During this time 27 patients (69%) developed at least one TCC recurrence. Eighteen patients had urothelial recurrences, and 9 patients had nonurothelial recurrences. Of these latter patients, 2 patients (5%) had local recurrences. No patient developed a port site metastasis. Eleven patients ultimately had disease progression and died from TCC 7-59 mo (median: 31) after the operation. On statistical analysis, tumor stage was the only factor significantly associated with death from the disease, and tumor location (ureter) was the only factor significantly associated with disease recurrence. Conclusions: The long-term overall and disease-specific survival rates after laparoscopic RNU for upper tract TCC are well within the range of results reported after open surgery. Thus, the results of the present study support the continued development of laparoscopic techniques in the management of this aggressive disease.

Original languageEnglish (US)
Pages (from-to)1639-1644
Number of pages6
JournalEuropean Urology
Volume51
Issue number6
DOIs
StatePublished - Jun 2007

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Transitional Cell Carcinoma
Recurrence
Ureter
Disease Management
Medical Records
Disease Progression
Neoplasms
Survival Rate
Neoplasm Metastasis

Keywords

  • Carcinoma
  • Kidney
  • Laparoscopy
  • Nephrectomy
  • Transitional cell
  • Ureter

ASJC Scopus subject areas

  • Urology

Cite this

Muntener, M., Nielsen, M. E., Romero, F. R., Schaeffer, E. M., Allaf, M. E., Brito, F. A. R., ... Jarrett, T. W. (2007). Long-Term Oncologic Outcome after Laparoscopic Radical Nephroureterectomy for Upper Tract Transitional Cell Carcinoma. European Urology, 51(6), 1639-1644. https://doi.org/10.1016/j.eururo.2007.01.038

Long-Term Oncologic Outcome after Laparoscopic Radical Nephroureterectomy for Upper Tract Transitional Cell Carcinoma. / Muntener, Michael; Nielsen, Matthew E.; Romero, Frederico R.; Schaeffer, Edward M.; Allaf, Mohamad E; Brito, Fabio Augusto R; Pavlovich, Christian; Kavoussi, Louis R.; Jarrett, Thomas W.

In: European Urology, Vol. 51, No. 6, 06.2007, p. 1639-1644.

Research output: Contribution to journalArticle

Muntener, M, Nielsen, ME, Romero, FR, Schaeffer, EM, Allaf, ME, Brito, FAR, Pavlovich, C, Kavoussi, LR & Jarrett, TW 2007, 'Long-Term Oncologic Outcome after Laparoscopic Radical Nephroureterectomy for Upper Tract Transitional Cell Carcinoma', European Urology, vol. 51, no. 6, pp. 1639-1644. https://doi.org/10.1016/j.eururo.2007.01.038
Muntener, Michael ; Nielsen, Matthew E. ; Romero, Frederico R. ; Schaeffer, Edward M. ; Allaf, Mohamad E ; Brito, Fabio Augusto R ; Pavlovich, Christian ; Kavoussi, Louis R. ; Jarrett, Thomas W. / Long-Term Oncologic Outcome after Laparoscopic Radical Nephroureterectomy for Upper Tract Transitional Cell Carcinoma. In: European Urology. 2007 ; Vol. 51, No. 6. pp. 1639-1644.
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