Long-term impact of early life events on physiology and behaviour

G. J. Boersma, T. L. Bale, P. Casanello, H. E. Lara, A. B. Lucion, D. Suchecki, K. L. Tamashiro

Research output: Contribution to journalReview articlepeer-review

Abstract

This review discusses the effects of stress and nutrition throughout development and summarises studies investigating how exposure to stress or alterations in nutrition during the pre-conception, prenatal and early postnatal periods can affect the long-term health of an individual. In general, the data presented here suggest that that anything signalling potential adverse conditions later in life, such as high levels of stress or low levels of food availability, will lead to alterations in the offspring, possibly of an epigenetic nature, preparing the offspring for these conditions later in life. However, when similar environmental conditions are not met in adulthood, these alterations may have maladaptive consequences, resulting in obesity and heightened stress sensitivity. The data also suggest that the mechanism underlying these adult phenotypes might be dependent on the type and the timing of exposure.

Original languageEnglish (US)
Pages (from-to)587-602
Number of pages16
JournalJournal of Neuroendocrinology
Volume26
Issue number9
DOIs
StatePublished - Sep 2014

Keywords

  • Animal model
  • Nutrition
  • Peri-natal
  • Stress

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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