Abstract
In this study, 118 consecutive adult patients with supratentorial gliomas underwent preoperative immunological monitoring, with particular regard to B-lymphocyte and T-lymphocyte markers. Most patients were treated surgically and with radiotherapy. Three months later, they were readmitted for postoperative immunological investigation and follow-up control. A total of 76 cases could thus be completely investigated and were statistically eligible for evaluation. A pronounced failure of T-cell-mediated immunity was observed: "E-active" rosette-forming cells and mitogen-induced blastogenesis tests turned out to be markedly depressed, with a slight postoperative recovery. Spontaneous cell-mediated cytotoxicity was significantly (p < 0.01) increased both in preoperative and postoperative findings. The main immunodiagnostic patterns (immunoglobulins assay, surface immunoglobulins, "mouse" rosettes) concerning the B-cell-dependent "pool" were found to be within normal limits.
Original language | English (US) |
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Pages (from-to) | 48-52 |
Number of pages | 5 |
Journal | Surgical neurology |
Volume | 16 |
Issue number | 1 |
DOIs | |
State | Published - Jul 1981 |
Externally published | Yes |
Keywords
- brain neoplasms
- immunobiology
- malignant gliomas
ASJC Scopus subject areas
- Surgery
- Clinical Neurology