Long-term immunological investigation of malignant intracranial gliomas

Massimo Gerosa, Grampiero Semenzato, Guiseppe Amadori, Alessandro Olivi, Antonio Rottlio, Mario Zuccarello, Giorgio Iraci

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, 118 consecutive adult patients with supratentorial gliomas underwent preoperative immunological monitoring, with particular regard to B-lymphocyte and T-lymphocyte markers. Most patients were treated surgically and with radiotherapy. Three months later, they were readmitted for postoperative immunological investigation and follow-up control. A total of 76 cases could thus be completely investigated and were statistically eligible for evaluation. A pronounced failure of T-cell-mediated immunity was observed: "E-active" rosette-forming cells and mitogen-induced blastogenesis tests turned out to be markedly depressed, with a slight postoperative recovery. Spontaneous cell-mediated cytotoxicity was significantly (p < 0.01) increased both in preoperative and postoperative findings. The main immunodiagnostic patterns (immunoglobulins assay, surface immunoglobulins, "mouse" rosettes) concerning the B-cell-dependent "pool" were found to be within normal limits.

Original languageEnglish (US)
Pages (from-to)48-52
Number of pages5
JournalSurgical neurology
Volume16
Issue number1
DOIs
StatePublished - Jul 1981

Keywords

  • brain neoplasms
  • immunobiology
  • malignant gliomas

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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