Long-term health-related quality of life after iatrogenic bile duct injury repair

Aslam Ejaz, Gaya Spolverato, Yuhree Kim, Rebecca Dodson, Jason K. Sicklick, Henry A. Pitt, Keith D. Lillemoe, John L. Cameron, Timothy M. Pawlik

Research output: Contribution to journalArticlepeer-review


Background Data on the effect of bile duct injuries (BDI) on health-related quality of life (HRQOL) are not well defined. We sought to assess long-term HRQOL after BDI repair in a large cohort of patients spanning a 23-year period.

Study Design We identified and mailed HRQOL questionnaires to all patients treated for major BDI after laparoscopic cholecystectomy between January 1, 1990 and December 31, 2012 at Johns Hopkins Hospital.

Results We identified 167 patients alive at the time of the study who met the inclusion criteria. Median age at BDI was 42 years (interquartile range 31 to 54 years); the majority of patients were female (n = 131 [78.4%]) and of white race (n = 137 [83.0%]). Most patients had Bismuth level 2 (n = 56 [33.7%]) or Bismuth level 3 (n = 40 [24.1%]) BDI. Surgical repair most commonly involved a Roux-en-Y hepaticojejunostomy (n = 142 [86.1%]). Sixty-two patients (37.1%) responded to the HRQOL questionnaire. Median follow-up was 169 months (interquartile range 125 to 222 months). At the time of BDI, mental health was most affected, with patients commonly reporting a depressed mood (49.2%) or low energy level (40.0%). These symptoms improved significantly after definitive repair (both p < 0.05). Limitations in physical activity and general health remained unchanged before and after surgical repair (both p > 0.05).

Conclusions Mental health concerns were more commonplace vs physical or general health issues among patients with BDI followed long term. Optimal multidisciplinary management of BDI can help restore HRQOL to preinjury levels.

Original languageEnglish (US)
Pages (from-to)923-932.e10
JournalJournal of the American College of Surgeons
Issue number5
StatePublished - Nov 1 2014

ASJC Scopus subject areas

  • Surgery


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