Long-term health-related quality of life after iatrogenic bile duct injury repair

Aslam Ejaz, Gaya Spolverato, Yuhree Kim, Rebecca Dodson, Jason K. Sicklick, Henry A. Pitt, Keith D. Lillemoe, John L Cameron, Timothy M. Pawlik

Research output: Contribution to journalArticle

Abstract

Background Data on the effect of bile duct injuries (BDI) on health-related quality of life (HRQOL) are not well defined. We sought to assess long-term HRQOL after BDI repair in a large cohort of patients spanning a 23-year period.

Study Design We identified and mailed HRQOL questionnaires to all patients treated for major BDI after laparoscopic cholecystectomy between January 1, 1990 and December 31, 2012 at Johns Hopkins Hospital.

Results We identified 167 patients alive at the time of the study who met the inclusion criteria. Median age at BDI was 42 years (interquartile range 31 to 54 years); the majority of patients were female (n = 131 [78.4%]) and of white race (n = 137 [83.0%]). Most patients had Bismuth level 2 (n = 56 [33.7%]) or Bismuth level 3 (n = 40 [24.1%]) BDI. Surgical repair most commonly involved a Roux-en-Y hepaticojejunostomy (n = 142 [86.1%]). Sixty-two patients (37.1%) responded to the HRQOL questionnaire. Median follow-up was 169 months (interquartile range 125 to 222 months). At the time of BDI, mental health was most affected, with patients commonly reporting a depressed mood (49.2%) or low energy level (40.0%). These symptoms improved significantly after definitive repair (both p <0.05). Limitations in physical activity and general health remained unchanged before and after surgical repair (both p > 0.05).

Conclusions Mental health concerns were more commonplace vs physical or general health issues among patients with BDI followed long term. Optimal multidisciplinary management of BDI can help restore HRQOL to preinjury levels.

Original languageEnglish (US)
Pages (from-to)923-932.e10
JournalJournal of the American College of Surgeons
Volume219
Issue number5
DOIs
StatePublished - Nov 1 2014

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Bile Ducts
Quality of Life
Wounds and Injuries
Bismuth
Mental Health
Time and Motion Studies
Laparoscopic Cholecystectomy
Health

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)

Cite this

Ejaz, A., Spolverato, G., Kim, Y., Dodson, R., Sicklick, J. K., Pitt, H. A., ... Pawlik, T. M. (2014). Long-term health-related quality of life after iatrogenic bile duct injury repair. Journal of the American College of Surgeons, 219(5), 923-932.e10. https://doi.org/10.1016/j.jamcollsurg.2014.04.024

Long-term health-related quality of life after iatrogenic bile duct injury repair. / Ejaz, Aslam; Spolverato, Gaya; Kim, Yuhree; Dodson, Rebecca; Sicklick, Jason K.; Pitt, Henry A.; Lillemoe, Keith D.; Cameron, John L; Pawlik, Timothy M.

In: Journal of the American College of Surgeons, Vol. 219, No. 5, 01.11.2014, p. 923-932.e10.

Research output: Contribution to journalArticle

Ejaz, A, Spolverato, G, Kim, Y, Dodson, R, Sicklick, JK, Pitt, HA, Lillemoe, KD, Cameron, JL & Pawlik, TM 2014, 'Long-term health-related quality of life after iatrogenic bile duct injury repair', Journal of the American College of Surgeons, vol. 219, no. 5, pp. 923-932.e10. https://doi.org/10.1016/j.jamcollsurg.2014.04.024
Ejaz, Aslam ; Spolverato, Gaya ; Kim, Yuhree ; Dodson, Rebecca ; Sicklick, Jason K. ; Pitt, Henry A. ; Lillemoe, Keith D. ; Cameron, John L ; Pawlik, Timothy M. / Long-term health-related quality of life after iatrogenic bile duct injury repair. In: Journal of the American College of Surgeons. 2014 ; Vol. 219, No. 5. pp. 923-932.e10.
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abstract = "Background Data on the effect of bile duct injuries (BDI) on health-related quality of life (HRQOL) are not well defined. We sought to assess long-term HRQOL after BDI repair in a large cohort of patients spanning a 23-year period.Study Design We identified and mailed HRQOL questionnaires to all patients treated for major BDI after laparoscopic cholecystectomy between January 1, 1990 and December 31, 2012 at Johns Hopkins Hospital.Results We identified 167 patients alive at the time of the study who met the inclusion criteria. Median age at BDI was 42 years (interquartile range 31 to 54 years); the majority of patients were female (n = 131 [78.4{\%}]) and of white race (n = 137 [83.0{\%}]). Most patients had Bismuth level 2 (n = 56 [33.7{\%}]) or Bismuth level 3 (n = 40 [24.1{\%}]) BDI. Surgical repair most commonly involved a Roux-en-Y hepaticojejunostomy (n = 142 [86.1{\%}]). Sixty-two patients (37.1{\%}) responded to the HRQOL questionnaire. Median follow-up was 169 months (interquartile range 125 to 222 months). At the time of BDI, mental health was most affected, with patients commonly reporting a depressed mood (49.2{\%}) or low energy level (40.0{\%}). These symptoms improved significantly after definitive repair (both p <0.05). Limitations in physical activity and general health remained unchanged before and after surgical repair (both p > 0.05).Conclusions Mental health concerns were more commonplace vs physical or general health issues among patients with BDI followed long term. Optimal multidisciplinary management of BDI can help restore HRQOL to preinjury levels.",
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AU - Dodson, Rebecca

AU - Sicklick, Jason K.

AU - Pitt, Henry A.

AU - Lillemoe, Keith D.

AU - Cameron, John L

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N2 - Background Data on the effect of bile duct injuries (BDI) on health-related quality of life (HRQOL) are not well defined. We sought to assess long-term HRQOL after BDI repair in a large cohort of patients spanning a 23-year period.Study Design We identified and mailed HRQOL questionnaires to all patients treated for major BDI after laparoscopic cholecystectomy between January 1, 1990 and December 31, 2012 at Johns Hopkins Hospital.Results We identified 167 patients alive at the time of the study who met the inclusion criteria. Median age at BDI was 42 years (interquartile range 31 to 54 years); the majority of patients were female (n = 131 [78.4%]) and of white race (n = 137 [83.0%]). Most patients had Bismuth level 2 (n = 56 [33.7%]) or Bismuth level 3 (n = 40 [24.1%]) BDI. Surgical repair most commonly involved a Roux-en-Y hepaticojejunostomy (n = 142 [86.1%]). Sixty-two patients (37.1%) responded to the HRQOL questionnaire. Median follow-up was 169 months (interquartile range 125 to 222 months). At the time of BDI, mental health was most affected, with patients commonly reporting a depressed mood (49.2%) or low energy level (40.0%). These symptoms improved significantly after definitive repair (both p <0.05). Limitations in physical activity and general health remained unchanged before and after surgical repair (both p > 0.05).Conclusions Mental health concerns were more commonplace vs physical or general health issues among patients with BDI followed long term. Optimal multidisciplinary management of BDI can help restore HRQOL to preinjury levels.

AB - Background Data on the effect of bile duct injuries (BDI) on health-related quality of life (HRQOL) are not well defined. We sought to assess long-term HRQOL after BDI repair in a large cohort of patients spanning a 23-year period.Study Design We identified and mailed HRQOL questionnaires to all patients treated for major BDI after laparoscopic cholecystectomy between January 1, 1990 and December 31, 2012 at Johns Hopkins Hospital.Results We identified 167 patients alive at the time of the study who met the inclusion criteria. Median age at BDI was 42 years (interquartile range 31 to 54 years); the majority of patients were female (n = 131 [78.4%]) and of white race (n = 137 [83.0%]). Most patients had Bismuth level 2 (n = 56 [33.7%]) or Bismuth level 3 (n = 40 [24.1%]) BDI. Surgical repair most commonly involved a Roux-en-Y hepaticojejunostomy (n = 142 [86.1%]). Sixty-two patients (37.1%) responded to the HRQOL questionnaire. Median follow-up was 169 months (interquartile range 125 to 222 months). At the time of BDI, mental health was most affected, with patients commonly reporting a depressed mood (49.2%) or low energy level (40.0%). These symptoms improved significantly after definitive repair (both p <0.05). Limitations in physical activity and general health remained unchanged before and after surgical repair (both p > 0.05).Conclusions Mental health concerns were more commonplace vs physical or general health issues among patients with BDI followed long term. Optimal multidisciplinary management of BDI can help restore HRQOL to preinjury levels.

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