Long-Term (>3 Years) Outcome and Predictors of Clinical Events After Insertion of Sirolimus-Eluting Stent in One or More Native Coronary Arteries (from the Israeli Arm of the e-Cypher Registry)

David Planer, Rafael Beyar, Yaron Almagor, Shmuel Banai, Victor Guetta, Hilton Miller, Ran Kornowski, Simcha Brandes, Ricardo Krakover, Mivi Solomon, Chaim Lotan

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to evaluate long-term (3.4 years) outcomes and predictors of clinical events in patients treated with sirolimus-eluting stents in the Israeli arm of the e-Cypher registry. From July 2002 to October 2003, 488 patients from 8 medical centers in Israel were enrolled in the e-Cypher registry. Nineteen patients with interventions in venous grafts were excluded from the final analysis. Long-term follow-up was completed for 98% of the remaining patients. There were 29 cases (6.3%) of death (3.9% cardiac and 2.4% noncardiac deaths). According to the broad academic research consortium definition of stent thrombosis, there were 19 cases (4%) of stent thrombosis (incidence density 0.9 cases/100 patient-years). There were 46 cases (9.9%) of target lesion revascularization and 76 cases (16.3%) of major adverse cardiac events (combination of death, myocardial infarction, and target lesion revascularization). Independent predictors of stent thrombosis were renal failure (hazard ratio 9.6, 95% confidence interval 1.9 to 47), stent length (hazard ratio 1.1, 95% confidence interval 1 to 1.2), and the off-label use of sirolimus-eluting stents (hazard ratio 5.3, 95% confidence interval 1.2 to 24). In conclusion, during >3 years of follow-up, stent thrombosis, major adverse cardiac events, and target lesion revascularization continued at constant rates over time. Clinical parameters such as renal failure and procedural parameters such as off-label use and stent length were independent predictors of stent thrombosis.

Original languageEnglish (US)
Pages (from-to)953-959
Number of pages7
JournalThe American Journal of Cardiology
Volume101
Issue number7
DOIs
StatePublished - Apr 1 2008
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'Long-Term (>3 Years) Outcome and Predictors of Clinical Events After Insertion of Sirolimus-Eluting Stent in One or More Native Coronary Arteries (from the Israeli Arm of the e-Cypher Registry)'. Together they form a unique fingerprint.

Cite this