Long-term function of ncgt vascular conduits in a multicenter trial: Evaluation of physical chemical parameters

P. N. Sawyer, R. Adamson, K. Butt, J. Fitzgerald, S. Haque, J. Landi, L. Malik, F. Mistry, N. Ramasamy, K. Reddy, B. Stanczewski, D. Kirschenbaum, Wiley F. Barker, Neal R. Glass, Roger Hallin, Martin J. Kaplitt, Richard J. Sanders, John A. Kennedy, Robert A. McAlexander, Thomas O. MurphyRobert S. Taylor, G. Melville Williams

Research output: Contribution to journalArticle

Abstract

Our experience with the NCGT graft has now encompassed 12 years in experimental animals and 4.5 years clinical experience with 134 grafts in man. It has previously been suggested that vessel wall structure, interface-charge, electric potential, and polarity of the blood intimal interface appear critical in the prevention of intravascular thrombosis in all vascular prosthetic bypass grafts.This concept has now been confirmed using ferritin, colloidal iron and fluorescamine intimal labelling. These provide a quantitative spacial characterization of the surface charges of several grafts, including the NCGT graft. Study indicates that each step in the production of the NCGT graft results in a cumulative increase in the structured negative charge of the vascular interface. The more dense the structured negative charge of the prosthesis, the more resistant is the graft to short and long-term thrombosis in experimental animals and man. The experience has been confirmed with a comparative analysis of implantation results in 105 patients up to 4.5 years with 65 to 70% patency rate over that time interval. Statistical analysis of parameters confirm again that the polarity and structure of the vascular interface is important in the effective function and patency rate of the grafts.

Original languageEnglish (US)
Pages (from-to)345-367
Number of pages23
JournalBiomaterials, Medical Devices, and Artificial Organs
Volume8
Issue number4
DOIs
StatePublished - Jan 1980

ASJC Scopus subject areas

  • Medicine(all)

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