Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells

Janet D. Siliciano, Joleen Kajdas, Diana Finzi, Thomas C. Quinn, Karen Chadwick, Joseph B. Margolick, Colin Kovacs, Stephen J. Gange, Robert F. Siliciano

Research output: Contribution to journalArticlepeer-review

Abstract

Latent HIV-1 persists in resting memory CD4+ T cells, even in patients receiving highly active antiretroviral therapy (HAART). It has been unclear how stable this latent reservoir is and whether its persistence reflects replenishment by low-level viremia. Here we show that even in treated patients who have had no detectable viremia for as long as 7 years, the reservoir decays so slowly (t1/2 = 44 months) that eradication is unlikely.

Original languageEnglish (US)
Pages (from-to)727-728
Number of pages2
JournalNature medicine
Volume9
Issue number6
DOIs
StatePublished - Jun 1 2003

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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