Abstract
We report single institution outcome of brief, intensive ara-C-based chemotherapy using bone marrow transplantation as primary intensification for untreated adult patients with acute lymphoblastic leukemia (ALL). Overall disease-free and overall survival were inferior to those reported with prolonged chemotherapy modeled on pediatric protocols. Survival and disease-free survival were superior for patients receiving allogeneic BMT compared with chemopurged autologous transplant or maintenance chemotherapy (patients ineligible for or declining BMT). In multivariate analysis, non-L2-FAB, higher ara-C dose, absence of CNS disease, non-Ph1+ karyotype, allogeneic BMT, T cell phenotype, and younger age were associated with improved disease-free survival. Autologous BMT was not superior to chemotherapy, and appears unlikely to provide adequate curative treatment for most adult ALL patients if not followed by maintenance.
Original language | English (US) |
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Pages (from-to) | 461-471 |
Number of pages | 11 |
Journal | Leukemia Research |
Volume | 26 |
Issue number | 5 |
DOIs | |
State | Published - 2002 |
Keywords
- 4-Hydroperoxycyclophosphamide
- Acute lymphoblastic leukemia (ALL)
- Autologous
- Bone marrow transplantation
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research