Long-term follow-up of hepatic adenoma and adenomatosis

analysis of size change on imaging with histopathological correlation

N. Shao, A. Pandey, M. A. Ghasabeh, P. Khoshpouri, P. Pandey, F. N. Varzaneh, M. Zarghampour, D. Fouladi, T. M. Pawlik, Robert A Anders, Ihab R Kamel

Research output: Contribution to journalArticle

Abstract

Aim: To analyse the change in size on follow-up of hepatic adenomas (HAs) and adenomatosis, and to investigate the relationship of imaging features with size change. Materials and methods: The study included 44 patients (142 lesions) who underwent magnetic resonance imaging (MRI) or computed tomography (CT) for diagnosis and follow-up of HA. The imaging features and percentage change in maximum tumour dimension were observed over a follow-up duration of up to 139 months. Results: With an average follow-up of 43 months, 37% lesions decreased in size, 58% were stable, 4% increased; one lesion regressed completely. Adenomas were stratified into size groups (<3, 3–5, and ≥5 cm). Size change among the three groups was similar (p>0.05). Percent size change was different for lesions followed for ≤12 months (−7.2%) compared with lesions followed for 13–60 months (−20.5%), and those followed for ≥60 months (−23.5%; p<0.05); there was no difference between lesions followed for 13–60 months and ≥60 months (p=0.523). Baseline size and percent size change was similar between the hepatocyte nuclear factor 1α-inactivated HA (HA-H) and inflammatory HA (HA-I) subtype (p>0.05). Conclusion: Most adenomas were either stable or regressed on follow-up. Size change was independent of baseline size. After an initial size decrease within 5 years, no further size reduction was noted on extended follow-up. The percent size change in the HA-H and HA-I subtype was similar.

Original languageEnglish (US)
JournalClinical Radiology
DOIs
StateAccepted/In press - Jan 1 2018

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Adenoma
Liver
Tomography
Magnetic Resonance Imaging
Neoplasms

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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Long-term follow-up of hepatic adenoma and adenomatosis : analysis of size change on imaging with histopathological correlation. / Shao, N.; Pandey, A.; Ghasabeh, M. A.; Khoshpouri, P.; Pandey, P.; Varzaneh, F. N.; Zarghampour, M.; Fouladi, D.; Pawlik, T. M.; Anders, Robert A; Kamel, Ihab R.

In: Clinical Radiology, 01.01.2018.

Research output: Contribution to journalArticle

Shao, N. ; Pandey, A. ; Ghasabeh, M. A. ; Khoshpouri, P. ; Pandey, P. ; Varzaneh, F. N. ; Zarghampour, M. ; Fouladi, D. ; Pawlik, T. M. ; Anders, Robert A ; Kamel, Ihab R. / Long-term follow-up of hepatic adenoma and adenomatosis : analysis of size change on imaging with histopathological correlation. In: Clinical Radiology. 2018.
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abstract = "Aim: To analyse the change in size on follow-up of hepatic adenomas (HAs) and adenomatosis, and to investigate the relationship of imaging features with size change. Materials and methods: The study included 44 patients (142 lesions) who underwent magnetic resonance imaging (MRI) or computed tomography (CT) for diagnosis and follow-up of HA. The imaging features and percentage change in maximum tumour dimension were observed over a follow-up duration of up to 139 months. Results: With an average follow-up of 43 months, 37{\%} lesions decreased in size, 58{\%} were stable, 4{\%} increased; one lesion regressed completely. Adenomas were stratified into size groups (<3, 3–5, and ≥5 cm). Size change among the three groups was similar (p>0.05). Percent size change was different for lesions followed for ≤12 months (−7.2{\%}) compared with lesions followed for 13–60 months (−20.5{\%}), and those followed for ≥60 months (−23.5{\%}; p<0.05); there was no difference between lesions followed for 13–60 months and ≥60 months (p=0.523). Baseline size and percent size change was similar between the hepatocyte nuclear factor 1α-inactivated HA (HA-H) and inflammatory HA (HA-I) subtype (p>0.05). Conclusion: Most adenomas were either stable or regressed on follow-up. Size change was independent of baseline size. After an initial size decrease within 5 years, no further size reduction was noted on extended follow-up. The percent size change in the HA-H and HA-I subtype was similar.",
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T2 - analysis of size change on imaging with histopathological correlation

AU - Shao, N.

AU - Pandey, A.

AU - Ghasabeh, M. A.

AU - Khoshpouri, P.

AU - Pandey, P.

AU - Varzaneh, F. N.

AU - Zarghampour, M.

AU - Fouladi, D.

AU - Pawlik, T. M.

AU - Anders, Robert A

AU - Kamel, Ihab R

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Aim: To analyse the change in size on follow-up of hepatic adenomas (HAs) and adenomatosis, and to investigate the relationship of imaging features with size change. Materials and methods: The study included 44 patients (142 lesions) who underwent magnetic resonance imaging (MRI) or computed tomography (CT) for diagnosis and follow-up of HA. The imaging features and percentage change in maximum tumour dimension were observed over a follow-up duration of up to 139 months. Results: With an average follow-up of 43 months, 37% lesions decreased in size, 58% were stable, 4% increased; one lesion regressed completely. Adenomas were stratified into size groups (<3, 3–5, and ≥5 cm). Size change among the three groups was similar (p>0.05). Percent size change was different for lesions followed for ≤12 months (−7.2%) compared with lesions followed for 13–60 months (−20.5%), and those followed for ≥60 months (−23.5%; p<0.05); there was no difference between lesions followed for 13–60 months and ≥60 months (p=0.523). Baseline size and percent size change was similar between the hepatocyte nuclear factor 1α-inactivated HA (HA-H) and inflammatory HA (HA-I) subtype (p>0.05). Conclusion: Most adenomas were either stable or regressed on follow-up. Size change was independent of baseline size. After an initial size decrease within 5 years, no further size reduction was noted on extended follow-up. The percent size change in the HA-H and HA-I subtype was similar.

AB - Aim: To analyse the change in size on follow-up of hepatic adenomas (HAs) and adenomatosis, and to investigate the relationship of imaging features with size change. Materials and methods: The study included 44 patients (142 lesions) who underwent magnetic resonance imaging (MRI) or computed tomography (CT) for diagnosis and follow-up of HA. The imaging features and percentage change in maximum tumour dimension were observed over a follow-up duration of up to 139 months. Results: With an average follow-up of 43 months, 37% lesions decreased in size, 58% were stable, 4% increased; one lesion regressed completely. Adenomas were stratified into size groups (<3, 3–5, and ≥5 cm). Size change among the three groups was similar (p>0.05). Percent size change was different for lesions followed for ≤12 months (−7.2%) compared with lesions followed for 13–60 months (−20.5%), and those followed for ≥60 months (−23.5%; p<0.05); there was no difference between lesions followed for 13–60 months and ≥60 months (p=0.523). Baseline size and percent size change was similar between the hepatocyte nuclear factor 1α-inactivated HA (HA-H) and inflammatory HA (HA-I) subtype (p>0.05). Conclusion: Most adenomas were either stable or regressed on follow-up. Size change was independent of baseline size. After an initial size decrease within 5 years, no further size reduction was noted on extended follow-up. The percent size change in the HA-H and HA-I subtype was similar.

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