Long-term follow-up of children treated with the modified Atkins diet

Wendy Chen, Eric H. Kossoff

Research output: Contribution to journalArticle

Abstract

The modified Atkins diet has been studied in mostly short-term clinical trials and case series. No studies have systematically examined the long-term benefits and side effects. The modified Atkins diet was started without prior ketogenic diet use in 87 children at the Johns Hopkins Hospital since 2002, of which 54 continued for more than 6 months. Children who had not been seen within the past 2 years were contacted by phone and email. At their most recent point during the modified Atkins diet (mean 19.9 months), 30 of 54 (55%) children with diet durations of more than 6 months achieved >50% improvement; 19 (35%) were seizure-free. Using an intent-to-treat analysis, at 12 months, 33 of 87 (38%) had >50% seizure reduction; 16 (18%) were seizure-free. These results are similar to published data for short-term modified Atkins diet and long-term ketogenic diet use. Side effects were predominantly elevations in lipid profile and gastrointestinal upset.

Original languageEnglish (US)
Pages (from-to)754-758
Number of pages5
JournalJournal of child neurology
Volume27
Issue number6
DOIs
StatePublished - Jun 1 2012

    Fingerprint

Keywords

  • Atkins
  • diet
  • epilepsy
  • ketogenic
  • long term

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this