TY - JOUR
T1 - Long-term exposure to air pollution and increased risk of membranous nephropathy in China
AU - Xu, Xin
AU - Wang, Guobao
AU - Chen, Nan
AU - Lu, Tao
AU - Nie, Sheng
AU - Xu, Gang
AU - Zhang, Ping
AU - Luo, Yang
AU - Wang, Yongping
AU - Wang, Xiaobin
AU - Schwartz, Joel
AU - Geng, Jian
AU - Hou, Fan Fan
N1 - Publisher Copyright:
Copyright © 2016 by the American Society of Nephrology.
PY - 2016/12
Y1 - 2016/12
N2 - The effect of air pollution on the changing pattern of glomerulopathy has not been studied.We estimated the profile of and temporal change in glomerular diseases in an 11-year renal biopsy series including 71,151 native biopsies at 938 hospitals spanning 282 cities in China from 2004 to 2014, and examined the association of long-termexposure to fine particulatematter of,2.5 mm(PM2.5)with glomerulopathy. After age and region standardization, we identified IgA nephropathy as the leading type of glomerulopathy, with a frequency of 28.1%, followed bymembranous nephropathy (MN), with a frequency of 23.4%. Notably, the adjusted odds for MN increased 13% annually over the 11-year study period, whereas the proportions of other major glomerulopathies remained stable. During the study period, 3-year average PM2.5 exposure varied among the 282 cities, ranging from 6 to 114 mg/m3 (mean, 52.6 mg/m3). Each 10 mg/m3 increase in PM2.5 concentration associated with 14% higher odds for MN (odds ratio, 1.14; 95% confidence interval, 1.10 to 1.18) in regions with PM2.5 concentration.70 mg/m3.We also found that higher 3-year average air quality index was associated with increased risk of MN. In conclusion, in this large renal biopsy series, the frequency of MN increased over the study period, and long-term exposure to high levels of PM2.5 was associated with an increased risk of MN.
AB - The effect of air pollution on the changing pattern of glomerulopathy has not been studied.We estimated the profile of and temporal change in glomerular diseases in an 11-year renal biopsy series including 71,151 native biopsies at 938 hospitals spanning 282 cities in China from 2004 to 2014, and examined the association of long-termexposure to fine particulatematter of,2.5 mm(PM2.5)with glomerulopathy. After age and region standardization, we identified IgA nephropathy as the leading type of glomerulopathy, with a frequency of 28.1%, followed bymembranous nephropathy (MN), with a frequency of 23.4%. Notably, the adjusted odds for MN increased 13% annually over the 11-year study period, whereas the proportions of other major glomerulopathies remained stable. During the study period, 3-year average PM2.5 exposure varied among the 282 cities, ranging from 6 to 114 mg/m3 (mean, 52.6 mg/m3). Each 10 mg/m3 increase in PM2.5 concentration associated with 14% higher odds for MN (odds ratio, 1.14; 95% confidence interval, 1.10 to 1.18) in regions with PM2.5 concentration.70 mg/m3.We also found that higher 3-year average air quality index was associated with increased risk of MN. In conclusion, in this large renal biopsy series, the frequency of MN increased over the study period, and long-term exposure to high levels of PM2.5 was associated with an increased risk of MN.
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U2 - 10.1681/ASN.2016010093
DO - 10.1681/ASN.2016010093
M3 - Article
C2 - 27365535
AN - SCOPUS:85017028224
VL - 27
SP - 3739
EP - 3746
JO - Journal of the American Society of Nephrology : JASN
JF - Journal of the American Society of Nephrology : JASN
SN - 1046-6673
IS - 12
ER -