Long-term effects of radiation therapy on white matter of the corpus callosum: a diffusion tensor imaging study in children

Monwabisi Makola, M. Douglas Ris, E. Mark Mahone, Keith Owen Yeates, Kim M. Cecil

Research output: Research - peer-reviewArticle

Abstract

Background: Despite improving survival rates, children are at risk for long-term cognitive and behavioral difficulties following the diagnosis and treatment of a brain tumor. Surgery, chemotherapy and radiation therapy have all been shown to impact the developing brain, especially the white matter. Objective: The purpose of this study was to determine the long-term effects of radiation therapy on white matter integrity, as measured by diffusion tensor imaging, in pediatric brain tumor patients 2 years after the end of radiation treatment, while controlling for surgical interventions. Materials and methods: We evaluated diffusion tensor imaging performed at two time points: a baseline 3 to 12 months after surgery and a follow-up approximately 2 years later in pediatric brain tumor patients. A region of interest analysis was performed within three regions of the corpus callosum. Diffusion tensor metrics were determined for participants (n=22) who underwent surgical tumor resection and radiation therapy and demographically matched with participants (n=22) who received surgical tumor resection only. Results: Analysis revealed that 2 years after treatment, the radiation treated group exhibited significantly lower fractional anisotropy and significantly higher radial diffusivity within the body of the corpus callosum compared to the group that did not receive radiation. Conclusion: The findings indicate that pediatric brain tumor patients treated with radiation therapy may be at greater risk of experiencing long-term damage to the body of the corpus callosum than those treated with surgery alone.

LanguageEnglish (US)
Pages1-8
Number of pages8
JournalPediatric Radiology
DOIs
StateAccepted/In press - Aug 26 2017

Fingerprint

Diffusion Tensor Imaging
Corpus Callosum
Brain Neoplasms
Radiotherapy
White Matter
Radiation
Pediatrics
Therapeutics
Neoplasms
Anisotropy
Survival Rate
Drug Therapy
Brain

Keywords

  • Brain
  • Brain tumor
  • Children
  • Corpus callosum
  • Diffusion tensor imaging
  • Magnetic resonance imaging
  • Radiation
  • White matter

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Radiology Nuclear Medicine and imaging

Cite this

Long-term effects of radiation therapy on white matter of the corpus callosum : a diffusion tensor imaging study in children. / Makola, Monwabisi; Douglas Ris, M.; Mark Mahone, E.; Yeates, Keith Owen; Cecil, Kim M.

In: Pediatric Radiology, 26.08.2017, p. 1-8.

Research output: Research - peer-reviewArticle

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