Long-term effects of chronic methamphetamine administration in rhesus monkeys

William L. Woolverton, George A. Ricaurte, Lysia S. Forno, Lewis S. Seiden

Research output: Contribution to journalArticlepeer-review

Abstract

Biochemical and neuropathological effects of exposure to a high dose regimen of methamphetamine were evaluated in rhesus monkeys approximately 4 years after the last drug injection. Concentrations of dopamine and serotonin in caudate were below control levels as were concentrations of serotonin in several other brain regions. These changes were more severe in a monkey that was exposed twice to the drug regimen. A decrease in caudate synaptosomal uptake of both neurotransmitters as well as neuropathological changes were evident in that monkey. Although it is possible that partial recovery occurred, these results strongly suggest that methamphetamine-induced neurotoxicity may be permanent.

Original languageEnglish (US)
Pages (from-to)73-78
Number of pages6
JournalBrain research
Volume486
Issue number1
DOIs
StatePublished - May 1 1989

Keywords

  • Brain
  • Dopamine
  • Methamphetamine
  • Neurotoxicity
  • Rhesus monkey
  • Serotonin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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