Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam

Vu Dinh Thiem; Jacqueline L. Deen; Lorenz von Seidlein; Do Gia Canh; Dang Duc Anh; Jin Kyung Park; Mohammad Ali; M. Carolina Danovaro-Holliday; Nguyen Dinh Son; Nguyen Thai Hoa; Jan Holmgren; John D. Clemens

doi:10.1016/j.vaccine.2006.03.008

Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam

Vu Dinh Thiem, Jacqueline L. Deen, Lorenz von Seidlein, Do Gia Canh, Dang Duc Anh, Jin Kyung Park, Mohammad Ali, M. Carolina Danovaro-Holliday, Nguyen Dinh Son, Nguyen Thai Hoa, Jan Holmgren, John D. Clemens

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

We assessed the long-term protection afforded by a killed whole-cell oral cholera vaccine produced in Vietnam. A mass immunization of children and adults with the killed whole-cell oral cholera vaccine was undertaken in half of the communes of Hue, Vietnam, in 1998; the remaining communes were immunized in 2000. No cholera was observed in Hue until 2003, when an outbreak of El Tor cholera made it possible to conduct a case-control study. The overall vaccine effectiveness 3-5 years after vaccination was 50% (9-63%). This low-cost, easily administered vaccine should be considered as a tool for the control of cholera.

Original language	English (US)
Pages (from-to)	4297-4303
Number of pages	7
Journal	Vaccine
Volume	24
Issue number	20
DOIs	https://doi.org/10.1016/j.vaccine.2006.03.008
State	Published - May 15 2006

Keywords

Cholera
Effectiveness
Vaccine

ASJC Scopus subject areas

Molecular Medicine
Immunology and Microbiology(all)
veterinary(all)
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2006.03.008

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title = "Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam",

abstract = "We assessed the long-term protection afforded by a killed whole-cell oral cholera vaccine produced in Vietnam. A mass immunization of children and adults with the killed whole-cell oral cholera vaccine was undertaken in half of the communes of Hue, Vietnam, in 1998; the remaining communes were immunized in 2000. No cholera was observed in Hue until 2003, when an outbreak of El Tor cholera made it possible to conduct a case-control study. The overall vaccine effectiveness 3-5 years after vaccination was 50% (9-63%). This low-cost, easily administered vaccine should be considered as a tool for the control of cholera.",

keywords = "Cholera, Effectiveness, Vaccine",

author = "Thiem, {Vu Dinh} and Deen, {Jacqueline L.} and {von Seidlein}, Lorenz and Canh, {Do Gia} and Anh, {Dang Duc} and Park, {Jin Kyung} and Mohammad Ali and Danovaro-Holliday, {M. Carolina} and Son, {Nguyen Dinh} and Hoa, {Nguyen Thai} and Jan Holmgren and Clemens, {John D.}",

note = "Funding Information: This work was supported by the Bill and Melinda Gates Foundation through the Diseases of Most Impoverished Program administered by the International Vaccine Institute; the Swedish International Development Cooperation Agency; the U.S. National Institute of Child Health and Human Development; and the World Health Organization. ",

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AU - Thiem, Vu Dinh

AU - Deen, Jacqueline L.

AU - von Seidlein, Lorenz

AU - Canh, Do Gia

AU - Anh, Dang Duc

AU - Park, Jin Kyung

AU - Ali, Mohammad

AU - Danovaro-Holliday, M. Carolina

AU - Son, Nguyen Dinh

AU - Hoa, Nguyen Thai

AU - Holmgren, Jan

AU - Clemens, John D.

N1 - Funding Information: This work was supported by the Bill and Melinda Gates Foundation through the Diseases of Most Impoverished Program administered by the International Vaccine Institute; the Swedish International Development Cooperation Agency; the U.S. National Institute of Child Health and Human Development; and the World Health Organization.

PY - 2006/5/15

Y1 - 2006/5/15

N2 - We assessed the long-term protection afforded by a killed whole-cell oral cholera vaccine produced in Vietnam. A mass immunization of children and adults with the killed whole-cell oral cholera vaccine was undertaken in half of the communes of Hue, Vietnam, in 1998; the remaining communes were immunized in 2000. No cholera was observed in Hue until 2003, when an outbreak of El Tor cholera made it possible to conduct a case-control study. The overall vaccine effectiveness 3-5 years after vaccination was 50% (9-63%). This low-cost, easily administered vaccine should be considered as a tool for the control of cholera.

AB - We assessed the long-term protection afforded by a killed whole-cell oral cholera vaccine produced in Vietnam. A mass immunization of children and adults with the killed whole-cell oral cholera vaccine was undertaken in half of the communes of Hue, Vietnam, in 1998; the remaining communes were immunized in 2000. No cholera was observed in Hue until 2003, when an outbreak of El Tor cholera made it possible to conduct a case-control study. The overall vaccine effectiveness 3-5 years after vaccination was 50% (9-63%). This low-cost, easily administered vaccine should be considered as a tool for the control of cholera.

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KW - Effectiveness

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Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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