Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam

Vu Dinh Thiem, Jacqueline L. Deen, Lorenz von Seidlein, Do Gia Canh, Dang Duc Anh, Jin Kyung Park, Mohammad Ali, M. Carolina Danovaro-Holliday, Nguyen Dinh Son, Nguyen Thai Hoa, Jan Holmgren, John D. Clemens

Research output: Contribution to journalArticle

Abstract

We assessed the long-term protection afforded by a killed whole-cell oral cholera vaccine produced in Vietnam. A mass immunization of children and adults with the killed whole-cell oral cholera vaccine was undertaken in half of the communes of Hue, Vietnam, in 1998; the remaining communes were immunized in 2000. No cholera was observed in Hue until 2003, when an outbreak of El Tor cholera made it possible to conduct a case-control study. The overall vaccine effectiveness 3-5 years after vaccination was 50% (9-63%). This low-cost, easily administered vaccine should be considered as a tool for the control of cholera.

Original languageEnglish (US)
Pages (from-to)4297-4303
Number of pages7
JournalVaccine
Volume24
Issue number20
DOIs
StatePublished - May 15 2006

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cholera
Vietnam
Cholera
Cholera Vaccines
mouth
Vaccines
vaccines
Mass Vaccination
cells
Disease Outbreaks
Case-Control Studies
Vaccination
Costs and Cost Analysis
case-control studies
immunization
vaccination

Keywords

  • Cholera
  • Effectiveness
  • Vaccine

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Thiem, V. D., Deen, J. L., von Seidlein, L., Canh, D. G., Anh, D. D., Park, J. K., ... Clemens, J. D. (2006). Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam. Vaccine, 24(20), 4297-4303. https://doi.org/10.1016/j.vaccine.2006.03.008

Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam. / Thiem, Vu Dinh; Deen, Jacqueline L.; von Seidlein, Lorenz; Canh, Do Gia; Anh, Dang Duc; Park, Jin Kyung; Ali, Mohammad; Danovaro-Holliday, M. Carolina; Son, Nguyen Dinh; Hoa, Nguyen Thai; Holmgren, Jan; Clemens, John D.

In: Vaccine, Vol. 24, No. 20, 15.05.2006, p. 4297-4303.

Research output: Contribution to journalArticle

Thiem, VD, Deen, JL, von Seidlein, L, Canh, DG, Anh, DD, Park, JK, Ali, M, Danovaro-Holliday, MC, Son, ND, Hoa, NT, Holmgren, J & Clemens, JD 2006, 'Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam', Vaccine, vol. 24, no. 20, pp. 4297-4303. https://doi.org/10.1016/j.vaccine.2006.03.008
Thiem VD, Deen JL, von Seidlein L, Canh DG, Anh DD, Park JK et al. Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam. Vaccine. 2006 May 15;24(20):4297-4303. https://doi.org/10.1016/j.vaccine.2006.03.008
Thiem, Vu Dinh ; Deen, Jacqueline L. ; von Seidlein, Lorenz ; Canh, Do Gia ; Anh, Dang Duc ; Park, Jin Kyung ; Ali, Mohammad ; Danovaro-Holliday, M. Carolina ; Son, Nguyen Dinh ; Hoa, Nguyen Thai ; Holmgren, Jan ; Clemens, John D. / Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam. In: Vaccine. 2006 ; Vol. 24, No. 20. pp. 4297-4303.
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