Abstract
We assessed the long-term protection afforded by a killed whole-cell oral cholera vaccine produced in Vietnam. A mass immunization of children and adults with the killed whole-cell oral cholera vaccine was undertaken in half of the communes of Hue, Vietnam, in 1998; the remaining communes were immunized in 2000. No cholera was observed in Hue until 2003, when an outbreak of El Tor cholera made it possible to conduct a case-control study. The overall vaccine effectiveness 3-5 years after vaccination was 50% (9-63%). This low-cost, easily administered vaccine should be considered as a tool for the control of cholera.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4297-4303 |
| Number of pages | 7 |
| Journal | Vaccine |
| Volume | 24 |
| Issue number | 20 |
| DOIs | |
| State | Published - May 15 2006 |
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Keywords
- Cholera
- Effectiveness
- Vaccine
ASJC Scopus subject areas
- Immunology
- Microbiology
- Virology
- Infectious Diseases
- Public Health, Environmental and Occupational Health
- veterinary(all)
Cite this
Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam. / Thiem, Vu Dinh; Deen, Jacqueline L.; von Seidlein, Lorenz; Canh, Do Gia; Anh, Dang Duc; Park, Jin Kyung; Ali, Mohammad; Danovaro-Holliday, M. Carolina; Son, Nguyen Dinh; Hoa, Nguyen Thai; Holmgren, Jan; Clemens, John D.
In: Vaccine, Vol. 24, No. 20, 15.05.2006, p. 4297-4303.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam
AU - Thiem, Vu Dinh
AU - Deen, Jacqueline L.
AU - von Seidlein, Lorenz
AU - Canh, Do Gia
AU - Anh, Dang Duc
AU - Park, Jin Kyung
AU - Ali, Mohammad
AU - Danovaro-Holliday, M. Carolina
AU - Son, Nguyen Dinh
AU - Hoa, Nguyen Thai
AU - Holmgren, Jan
AU - Clemens, John D.
PY - 2006/5/15
Y1 - 2006/5/15
N2 - We assessed the long-term protection afforded by a killed whole-cell oral cholera vaccine produced in Vietnam. A mass immunization of children and adults with the killed whole-cell oral cholera vaccine was undertaken in half of the communes of Hue, Vietnam, in 1998; the remaining communes were immunized in 2000. No cholera was observed in Hue until 2003, when an outbreak of El Tor cholera made it possible to conduct a case-control study. The overall vaccine effectiveness 3-5 years after vaccination was 50% (9-63%). This low-cost, easily administered vaccine should be considered as a tool for the control of cholera.
AB - We assessed the long-term protection afforded by a killed whole-cell oral cholera vaccine produced in Vietnam. A mass immunization of children and adults with the killed whole-cell oral cholera vaccine was undertaken in half of the communes of Hue, Vietnam, in 1998; the remaining communes were immunized in 2000. No cholera was observed in Hue until 2003, when an outbreak of El Tor cholera made it possible to conduct a case-control study. The overall vaccine effectiveness 3-5 years after vaccination was 50% (9-63%). This low-cost, easily administered vaccine should be considered as a tool for the control of cholera.
KW - Cholera
KW - Effectiveness
KW - Vaccine
UR - http://www.scopus.com/inward/record.url?scp=33646142274&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646142274&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2006.03.008
DO - 10.1016/j.vaccine.2006.03.008
M3 - Article
VL - 24
SP - 4297
EP - 4303
JO - Vaccine
JF - Vaccine
SN - 0264-410X
IS - 20
ER -