Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam

Vu Dinh Thiem; Jacqueline L. Deen; Lorenz von Seidlein; Do Gia Canh; Dang Duc Anh; Jin Kyung Park; Mohammad Ali; M. Carolina Danovaro-Holliday; Nguyen Dinh Son; Nguyen Thai Hoa; Jan Holmgren; John D. Clemens

doi:10.1016/j.vaccine.2006.03.008

Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam

Vu Dinh Thiem, Jacqueline L. Deen, Lorenz von Seidlein, Do Gia Canh, Dang Duc Anh, Jin Kyung Park, Mohammad Ali, M. Carolina Danovaro-Holliday, Nguyen Dinh Son, Nguyen Thai Hoa, Jan Holmgren, John D. Clemens

Bloomberg School of Public Health

Research output: Contribution to journal › Article

Abstract

We assessed the long-term protection afforded by a killed whole-cell oral cholera vaccine produced in Vietnam. A mass immunization of children and adults with the killed whole-cell oral cholera vaccine was undertaken in half of the communes of Hue, Vietnam, in 1998; the remaining communes were immunized in 2000. No cholera was observed in Hue until 2003, when an outbreak of El Tor cholera made it possible to conduct a case-control study. The overall vaccine effectiveness 3-5 years after vaccination was 50% (9-63%). This low-cost, easily administered vaccine should be considered as a tool for the control of cholera.

Original language	English (US)
Pages (from-to)	4297-4303
Number of pages	7
Journal	Vaccine
Volume	24
Issue number	20
DOIs	https://doi.org/10.1016/j.vaccine.2006.03.008
State	Published - May 15 2006

Keywords

Cholera
Effectiveness
Vaccine

ASJC Scopus subject areas

Molecular Medicine
Immunology and Microbiology(all)
veterinary(all)
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2006.03.008

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Thiem, V. D., Deen, J. L., von Seidlein, L., Canh, D. G., Anh, D. D., Park, J. K., Ali, M., Danovaro-Holliday, M. C., Son, N. D., Hoa, N. T., Holmgren, J., & Clemens, J. D. (2006). Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam. Vaccine, 24(20), 4297-4303. https://doi.org/10.1016/j.vaccine.2006.03.008

Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam. / Thiem, Vu Dinh; Deen, Jacqueline L.; von Seidlein, Lorenz; Canh, Do Gia; Anh, Dang Duc; Park, Jin Kyung; Ali, Mohammad; Danovaro-Holliday, M. Carolina; Son, Nguyen Dinh; Hoa, Nguyen Thai; Holmgren, Jan; Clemens, John D.

In: Vaccine, Vol. 24, No. 20, 15.05.2006, p. 4297-4303.

Research output: Contribution to journal › Article

Thiem, Vu Dinh ; Deen, Jacqueline L. ; von Seidlein, Lorenz ; Canh, Do Gia ; Anh, Dang Duc ; Park, Jin Kyung ; Ali, Mohammad ; Danovaro-Holliday, M. Carolina ; Son, Nguyen Dinh ; Hoa, Nguyen Thai ; Holmgren, Jan ; Clemens, John D. / Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam. In: Vaccine. 2006 ; Vol. 24, No. 20. pp. 4297-4303.

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