Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam

Vu Dinh Thiem, Jacqueline L. Deen, Lorenz von Seidlein, Do Gia Canh, Dang Duc Anh, Jin Kyung Park, Mohammad Ali, M. Carolina Danovaro-Holliday, Nguyen Dinh Son, Nguyen Thai Hoa, Jan Holmgren, John D. Clemens

Research output: Contribution to journalArticle

Abstract

We assessed the long-term protection afforded by a killed whole-cell oral cholera vaccine produced in Vietnam. A mass immunization of children and adults with the killed whole-cell oral cholera vaccine was undertaken in half of the communes of Hue, Vietnam, in 1998; the remaining communes were immunized in 2000. No cholera was observed in Hue until 2003, when an outbreak of El Tor cholera made it possible to conduct a case-control study. The overall vaccine effectiveness 3-5 years after vaccination was 50% (9-63%). This low-cost, easily administered vaccine should be considered as a tool for the control of cholera.

Original languageEnglish (US)
Pages (from-to)4297-4303
Number of pages7
JournalVaccine
Volume24
Issue number20
DOIs
StatePublished - May 15 2006

Keywords

  • Cholera
  • Effectiveness
  • Vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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  • Cite this

    Thiem, V. D., Deen, J. L., von Seidlein, L., Canh, D. G., Anh, D. D., Park, J. K., Ali, M., Danovaro-Holliday, M. C., Son, N. D., Hoa, N. T., Holmgren, J., & Clemens, J. D. (2006). Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam. Vaccine, 24(20), 4297-4303. https://doi.org/10.1016/j.vaccine.2006.03.008