Long-Term effect of population screening for diabetes on cardiovascular morbidity, self-rated health, and health behavior

Justin B. Echouffo-Tcheugui, Rebecca K. Simmons, A. Toby Prevost, Kate M. Williams, Ann Louise Kinmonth, Nicholas J. Wareham, Simon J. Griffin

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


PURPOSE There is limited trial evidence concerning the long-term effects of screening for type 2 diabetes on population morbidity. We examined the effect of a population-based diabetes screening program on cardiovascular morbidity, self-rated health, and health-related behaviors. METHODS We conducted a pragmatic, parallel-group, cluster-randomized controlled trial of diabetes screening (the ADDITION-Cambridge study) including 18,875 individuals aged 40 to 69 years at high risk of diabetes in 32 general practices in eastern England (27 practices randomly allocated to screening, 5 to no-screening for control). Of those eligible for screening, 466 (2.9%) were diagnosed with diabetes. Seven years after randomization, a random sample of patients was sent a postal questionnaire: 15% from the screening group (including diabetes screening visit attenders and non-attenders) and 40% from the noscreening control group. Self-reported cardiovascular morbidity, self-rated health (using the SF-8 Health Survey and EQ-5D instrument), and health behaviors were compared between trial groups using an intention-to-screen analysis. RESULTS Of the 3,286 questionnaires mailed out, 1,995 (61%) were returned, with 1,945 included in the analysis (screening: 1,373; control: 572). At 7 years, there were no significant differences between the screening and control groups in the proportion of participants reporting heart attack or stroke (OR = 0.90, 95% CI, 0.71-1.15); SF-8 physical health summary score as an indicator of selfrated health status (β –0.33, 95% CI, –1.80 to 1.14); EQ-5D visual analogue score (β: 0.80, 95% CI, –1.28 to 2.87); total physical activity (β 0.50, 95% CI, –4.08 to 5.07); current smoking (OR 0.97, 95% CI, 0.72 to 1.32); and alcohol consumption (β 0.14, 95% CI, –1.07 to 1.35). CONCLUSIONS Invitation to screening for type 2 diabetes appears to have limited impact on population levels of cardiovascular morbidity, self-rated health status, and health behavior after 7 years.

Original languageEnglish (US)
Pages (from-to)149-157
Number of pages9
JournalAnnals of family medicine
Issue number2
StatePublished - 2015
Externally publishedYes


  • ADDITION-Cambridge
  • Cardiovascular morbidity
  • Diabetes
  • Health behavior
  • Screening
  • Self-rated health

ASJC Scopus subject areas

  • Family Practice


Dive into the research topics of 'Long-Term effect of population screening for diabetes on cardiovascular morbidity, self-rated health, and health behavior'. Together they form a unique fingerprint.

Cite this