Long-Term Depression of mGluR1 Signaling

Yunju Jin, Sang Jeong Kim, Jun Kim, Paul F. Worley, David J. Linden

Research output: Contribution to journalArticle

Abstract

Glutamate produces both fast excitation through activation of ionotropic receptors and slower actions through metabotropic receptors (mGluRs). To date, ionotropic but not metabotropic neurotransmission has been shown to undergo long-term synaptic potentiation and depression. Burst stimulation of parallel fibers releases glutamate, which activates perisynaptic mGluR1 in the dendritic spines of cerebellar Purkinje cells. Here, we show that the mGluR1-dependent slow EPSC and its coincident Ca transient were selectively and persistently depressed by repeated climbing fiber-evoked depolarization of Purkinje cells in brain slices. LTD(mGluR1) was also observed when slow synaptic current was evoked by exogenous application of a group I mGluR agonist, implying a postsynaptic expression mechanism. Ca imaging further revealed that LTD(mGluR1) was expressed as coincident attenuation of both limbs of mGluR1 signaling: the slow EPSC and PLC/IP3-mediated dendritic Ca mobilization. Thus, different patterns of neural activity can evoke LTD of either fast ionotropic or slow mGluR1-mediated synaptic signaling.

Original languageEnglish (US)
Pages (from-to)277-287
Number of pages11
JournalNeuron
Volume55
Issue number2
DOIs
StatePublished - Jul 19 2007

Keywords

  • CELLBIO
  • SIGNALING
  • SYSNEURO

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Long-Term Depression of mGluR1 Signaling'. Together they form a unique fingerprint.

  • Cite this