Long-term daclizumab therapy for the treatment of noninfectious ocular inflammatory disease

Keith Wroblewski, H. Nida Sen, Steven Yeh, Lisa Faia, Zhuging Li, Pushpa Sran, Sapna Gangaputra, Susan Vitale, Patti Sherry, Robert Nussenblatt

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Safety and efficacy of daclizumab during an 11-year period. Design: Structured, retrospective chart review. Participants: Thirty-nine patients. Methods: Patients with chronic, noninfectious intermediate and/or posterior uveitis. Results: Thirty-nine patients (78 eyes) were treated for a mean of 40.3 months. Visual acuity improved by ≥2 lines in the better eye in 7 patients (18.4%) and worsened by 2 lines in 6 patients (15.8%) with a mean of 2.8 Snellen lines of vision lost per eye. Six eyes with vitreous cell less than grade 2 lost 2 lines of vision and 7 eyes with less than grade 2 vitreous cell improved 2 lines. Mean number of immunosuppressive medications per patient decreased from 1.89 medications/patient to 1.17 medications/patient. The average number of periocular injections per patient was 1.46 (range, 0-9). The mean number of flares was 2.05/patient (range, 0-12), with the rate being 0.62 flares per patient-year. Four patients developed cancer during the course of this study. Mean time to onset of malignancy was 26 months and the mean age in this group was 49 years. Conclusions: Daclizumab demonstrated efficacy in the reduction of concomitant immunosuppressive medication, stabilization of visual acuity, and the prevention of uveitic flares in most cases. Dermatologic complications were the most frequently observed adverse event in our series. Four patients developed solid tumor malignancies during this 11-year period.

Original languageEnglish (US)
Pages (from-to)322-328
Number of pages7
JournalCanadian Journal of Ophthalmology
Volume46
Issue number4
DOIs
StatePublished - Aug 2011
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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